PMID- 31810553
OWN - NLM
STAT- MEDLINE
DCOM- 20200415
LR  - 20200415
IS  - 1937-6448 (Print)
IS  - 1937-6448 (Linking)
VI  - 348
DP  - 2019
TI  - Interplay between dendritic cells and cancer cells.
PG  - 179-215
LID - S1937-6448(19)30071-1 [pii]
LID - 10.1016/bs.ircmb.2019.07.008 [doi]
AB  - Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring 
      about resistance to infection and tolerance to self. Cancers can exploit DCs to 
      evade immunity, but DCs also can generate resistance to cancer. Owing to their 
      capacity to capture, process, and present antigens to naive T cells, thereby 
      launching adaptive immunity, DCs are poised to play a critical role in cancer 
      recognition and rejection. As such, DCs represent a solution for the expansion 
      and infiltration of T cells with tumor-rejecting properties. Indeed, clinical 
      responses to checkpoint blockade, such as anti-PD-1, are linked to the presence 
      of T cell immunity to cancer-specific antigens. However, only a fraction of 
      patients has clinical benefit. Unraveling the molecular pathways controlling 
      DC-cancer interplay will therefore pave the way for identifying new targets for 
      therapy that overcome limitations of current treatments and promote long-term 
      cancer control.
CI  - (c) 2019 Elsevier Inc. All rights reserved.
FAU - Martinek, Jan
AU  - Martinek J
AD  - The Jackson Laboratory for Genomic Medicine, Farmington, CT, United States.
FAU - Wu, Te-Chia
AU  - Wu TC
AD  - The Jackson Laboratory for Genomic Medicine, Farmington, CT, United States.
FAU - Cadena, Diana
AU  - Cadena D
AD  - The Jackson Laboratory for Genomic Medicine, Farmington, CT, United States.
FAU - Banchereau, Jacques
AU  - Banchereau J
AD  - The Jackson Laboratory for Genomic Medicine, Farmington, CT, United States. 
      Electronic address: jacques.banchereau@jax.org.
FAU - Palucka, Karolina
AU  - Palucka K
AD  - The Jackson Laboratory for Genomic Medicine, Farmington, CT, United States. 
      Electronic address: karolina.palucka@jax.org.
LA  - eng
GR  - R01 CA219880/CA/NCI NIH HHS/United States
GR  - U01 AI124297/AI/NIAID NIH HHS/United States
GR  - P30 CA034196/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190830
PL  - Netherlands
TA  - Int Rev Cell Mol Biol
JT  - International review of cell and molecular biology
JID - 101475846
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/pathology
MH  - Humans
MH  - Inflammation/drug therapy/immunology/pathology
MH  - Neoplasms/drug therapy/*immunology/pathology
OTO - NOTNLM
OT  - Cancer
OT  - Dendritic cells
OT  - Immunotherapy
OT  - Oncoimmunology
OT  - T cells
EDAT- 2019/12/08 06:00
MHDA- 2020/04/16 06:00
CRDT- 2019/12/08 06:00
PHST- 2019/12/08 06:00 [entrez]
PHST- 2019/12/08 06:00 [pubmed]
PHST- 2020/04/16 06:00 [medline]
AID - S1937-6448(19)30071-1 [pii]
AID - 10.1016/bs.ircmb.2019.07.008 [doi]
PST - ppublish
SO  - Int Rev Cell Mol Biol. 2019;348:179-215. doi: 10.1016/bs.ircmb.2019.07.008. Epub 
      2019 Aug 30.