PMID- 31811415
OWN - NLM
STAT- MEDLINE
DCOM- 20200727
LR  - 20210330
IS  - 1432-0711 (Electronic)
IS  - 0932-0067 (Linking)
VI  - 301
IP  - 2
DP  - 2020 Feb
TI  - Placental protein expression of kisspeptin-1 (KISS1) and the kisspeptin-1 
      receptor (KISS1R) in pregnancy complicated by diabetes mellitus or preeclampsia.
PG  - 437-445
LID - 10.1007/s00404-019-05408-1 [doi]
AB  - PURPOSE: Kisspeptins regulate the trophoblast invasion. The disturbance of this 
      process might lead to the development of preeclampsia (PE). Diabetes mellitus 
      (DM) is associated with the high rate of this complication. The main hypothesis 
      was to investigate the placental protein expression of kisspeptin-1 (KISS1) and 
      its receptor (KISS1R) in diabetic, preeclamptic, and healthy pregnancies. 
      METHODS: Placentae (n = 65) were divided into the following groups: the control 
      group (n = 20), either PE or non-PE type-1 diabetes mellitus (T1DM) (n = 10), 
      either PE or non-PE type-2 diabetes mellitus (T2DM) (n = 10), either PE or non-PE 
      gestational diabetes mellitus (GDM) (n = 10) and preeclampsia without diabetes 
      (PE) (n = 15). Immunohistochemistry analysis was used for demonstrating the 
      presence and location of KISS1/KISS1R in placental tissue and to measure the area 
      of immunopositive expression. Correlation analyses were performed to detect the 
      links between protein expression of these biomarkers and the main obstetric 
      outcomes. RESULTS: The highest placental protein expressions of KISS1 were 
      detected in the PE (35.4%) and GDM (33.2%) groups. In case of DM, levels of KISS1 
      expression depended on the presence of PE and were higher compared with DM no PE 
      and control groups: (30.6%) in T1DM + PE and (30.1%) in T2DM + PE group. The 
      lowest expression was detected in the control group (14.1%). The expression of 
      KISS1R was higher in DM and PE compared to the control group. We detected the 
      strong direct link between PE and placental expression of KISS1 (r = 0.81) and 
      KISS1R (r = 0.56), and inverse correlation link between KISS1 and preterm birth 
      weight (r = - 0.73). The low correlation links were found between KISS1 and IUGR 
      (r = 0.29), and preterm birth (r = 0.24). The same trend was detected for KISS1R. 
      We did not find any significant correlations between placental expressions of 
      KISS/KISS1R and placental weight or HbA1c levels. CONCLUSION: Increased 
      expression levels of KISS1 and KISS1R in case of diabetes mellitus may play a 
      role in the altered placentation process and lead to the development of 
      preeclampsia.
FAU - Kapustin, R V
AU  - Kapustin RV
AUID- ORCID: 0000-0002-2783-3032
AD  - D.O. Ott Institute of Obstetrics Gynaecology, and Reproductive Medicine, 3 
      Mendeleyevskaya Line, Saint Petersburg, 199034, Russian Federation. 
      kapustin.roman@gmail.com.
FAU - Drobintseva, A O
AU  - Drobintseva AO
AUID- ORCID: 0000-0002-6833-6243
AD  - D.O. Ott Institute of Obstetrics Gynaecology, and Reproductive Medicine, 3 
      Mendeleyevskaya Line, Saint Petersburg, 199034, Russian Federation.
FAU - Alekseenkova, E N
AU  - Alekseenkova EN
AUID- ORCID: 0000-0003-1409-5680
AD  - D.O. Ott Institute of Obstetrics Gynaecology, and Reproductive Medicine, 3 
      Mendeleyevskaya Line, Saint Petersburg, 199034, Russian Federation.
FAU - Onopriychuk, A R
AU  - Onopriychuk AR
AUID- ORCID: 0000-0002-3332-4920
AD  - D.O. Ott Institute of Obstetrics Gynaecology, and Reproductive Medicine, 3 
      Mendeleyevskaya Line, Saint Petersburg, 199034, Russian Federation.
FAU - Arzhanova, O N
AU  - Arzhanova ON
AUID- ORCID: 0000-0003-3059-9811
AD  - D.O. Ott Institute of Obstetrics Gynaecology, and Reproductive Medicine, 3 
      Mendeleyevskaya Line, Saint Petersburg, 199034, Russian Federation.
FAU - Polyakova, V O
AU  - Polyakova VO
AUID- ORCID: 0000-0001-8682-9909
AD  - D.O. Ott Institute of Obstetrics Gynaecology, and Reproductive Medicine, 3 
      Mendeleyevskaya Line, Saint Petersburg, 199034, Russian Federation.
FAU - Kvetnoy, I M
AU  - Kvetnoy IM
AUID- ORCID: 0000-0001-7302-5581
AD  - D.O. Ott Institute of Obstetrics Gynaecology, and Reproductive Medicine, 3 
      Mendeleyevskaya Line, Saint Petersburg, 199034, Russian Federation.
LA  - eng
PT  - Journal Article
DEP - 20191206
PL  - Germany
TA  - Arch Gynecol Obstet
JT  - Archives of gynecology and obstetrics
JID - 8710213
RN  - 0 (KISS1 protein, human)
RN  - 0 (Kisspeptins)
RN  - 0 (Receptors, Kisspeptin-1)
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Diabetes, Gestational/*genetics
MH  - Female
MH  - Humans
MH  - Kisspeptins/*metabolism
MH  - Pre-Eclampsia/*genetics
MH  - Pregnancy
MH  - Receptors, Kisspeptin-1/*metabolism
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Gestational diabetes
OT  - Kisspeptins
OT  - Placenta
OT  - Pre-gestational diabetes
OT  - Preeclampsia
EDAT- 2019/12/08 06:00
MHDA- 2020/07/28 06:00
CRDT- 2019/12/08 06:00
PHST- 2019/04/22 00:00 [received]
PHST- 2019/12/02 00:00 [accepted]
PHST- 2019/12/08 06:00 [pubmed]
PHST- 2020/07/28 06:00 [medline]
PHST- 2019/12/08 06:00 [entrez]
AID - 10.1007/s00404-019-05408-1 [pii]
AID - 10.1007/s00404-019-05408-1 [doi]
PST - ppublish
SO  - Arch Gynecol Obstet. 2020 Feb;301(2):437-445. doi: 10.1007/s00404-019-05408-1. 
      Epub 2019 Dec 6.