PMID- 31812790
OWN - NLM
STAT- MEDLINE
DCOM- 20200325
LR  - 20211204
IS  - 1879-1107 (Electronic)
IS  - 1096-4959 (Linking)
VI  - 241
DP  - 2020 Mar
TI  - A review on fish immuno-nutritional response to indispensable amino acids in 
      relation to TOR, NF-kappaB and Nrf2 signaling pathways: Trends and prospects.
PG  - 110389
LID - S1096-4959(19)30348-3 [pii]
LID - 10.1016/j.cbpb.2019.110389 [doi]
AB  - Indispensable amino acids (IAAs) are important regulators of key metabolic 
      pathways associated with protein synthesis, tight junction proteins, inflammatory 
      cytokines and immune-antioxidant related signaling molecules. However, the 
      information pertaining to the immune functions of IAAs in relation to molecular 
      approaches for commercially important fish species are scarce and discordant. 
      This review summarizes the dietary requirements for IAAs necessary for improved 
      growth and immune response in variety of fish species, using molecular approaches 
      (nutrigenomics), particularly the interrelationships between IAAs and genes. 
      Briefly, antioxidant status of fish as well as gene transcriptions regulating 
      antioxidant enzymes are profoundly governed by the nutritional factors including 
      a set of IAAs, and these genes expression are often regulated by the nuclear 
      factor erythoid 2-related factor 2 signaling pathway (Nrf2). IAAs level could 
      also attenuate the inflammatory response in fish partly by down-regulating the 
      expression levels of pro-inflammatory cytokines and up-regulating the 
      anti-inflammatory cytokines. The regulation of these cytokines by IAAs could be 
      mediated by the signaling molecules nuclear transcription factor-kappaB (NF-kappaB) and 
      target of rapamycin (TOR). Overall, this review provides clear and recent 
      molecular mechanisms of fish immuno-nutritional interrelation and highlights 
      regulatory pathways underlying dietary IAAs mediated enhancement in the 
      antioxidant, anti-inflammatory, and immune defense capacities, presenting trends 
      and future perspectives.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Habte-Tsion, Habte-Michael
AU  - Habte-Tsion HM
AD  - School of Aquaculture and Aquatic Sciences, College of Agriculture, Communities, 
      and the Environment, Kentucky State University, Frankfort, KY 40601, USA. 
      Electronic address: mike2692011@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191205
PL  - England
TA  - Comp Biochem Physiol B Biochem Mol Biol
JT  - Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
JID - 9516061
RN  - 0 (Amino Acids, Essential)
RN  - 0 (Cytokines)
RN  - 0 (Fish Proteins)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NF-kappa B)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Amino Acids, Essential/*pharmacology
MH  - Animals
MH  - Cytokines/metabolism
MH  - Fish Proteins/metabolism
MH  - Fishes/*immunology/*metabolism
MH  - Immune System/metabolism
MH  - NF-E2-Related Factor 2/*metabolism
MH  - NF-kappa B/*metabolism
MH  - Nutrition Assessment
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - Fish
OT  - Immuno-nutrition
OT  - Indispensable amino acids
OT  - Nutrigenomics
OT  - Signaling pathways
COIS- Declaration of Competing Interest None.
EDAT- 2019/12/10 06:00
MHDA- 2020/03/26 06:00
CRDT- 2019/12/09 06:00
PHST- 2019/06/26 00:00 [received]
PHST- 2019/10/25 00:00 [revised]
PHST- 2019/12/03 00:00 [accepted]
PHST- 2019/12/10 06:00 [pubmed]
PHST- 2020/03/26 06:00 [medline]
PHST- 2019/12/09 06:00 [entrez]
AID - S1096-4959(19)30348-3 [pii]
AID - 10.1016/j.cbpb.2019.110389 [doi]
PST - ppublish
SO  - Comp Biochem Physiol B Biochem Mol Biol. 2020 Mar;241:110389. doi: 
      10.1016/j.cbpb.2019.110389. Epub 2019 Dec 5.