PMID- 31813303
OWN - NLM
STAT- MEDLINE
DCOM- 20200302
LR  - 20200302
IS  - 1744-8344 (Electronic)
IS  - 1477-9072 (Linking)
VI  - 17
IP  - 12
DP  - 2019 Dec
TI  - Treatment strategies for mixed aortic valve disease in nonelderly patients.
PG  - 873-882
LID - 10.1080/14779072.2019.1702520 [doi]
AB  - Introduction: Mixed aortic valve disease (MAVD) is defined by simultaneous 
      occurrence of aortic stenosis (AS) and aortic regurgitation (AR). In our review, 
      we focus on treatment options for nonelderly MAVD patients (age<55 years), who 
      suffer from congenital aortic valve disease (unicuspid/bicuspid aortic 
      valves).Areas covered: A systematic literature search was performed on PubMed and 
      Embase databases using the following terms: mixed aortic valve disease, aortic 
      stenosis/regurgitation, bicuspid/unicuspid aortic valve, mechanical/bioprosthetic 
      aortic valve replacement, TAVR, Ross procedure. After preselection of title and 
      abstracts, two authors (M.S. and E.G.) assessed the methodological quality of the 
      full-text articles prior to final inclusion in the manuscript.Expert opinion: 
      Currently, no ideal valvular substitutes are available in the treatment of 
      nonelderly MAVD patients. Mechanical valves are associated with a reduced life 
      expectancy due to a combination of prothesis-associated factors, mainly 
      thrombotic and bleeding complications. Bioprostheses degenerate in the second 
      decade and re-operations are inevitable, which also limit life expectancy. 
      Long-term outcomes and durability of transcatheter aortic valve replacement are 
      currently unknown. Finally, only Ross procedure is a therapeutic option with 
      excellent long-term outcomes comparable to the healthy population. However, the 
      Ross procedure has some important drawbacks and should therefore be only 
      performed in expert centers and in well-selected patients.
FAU - Von Stumm, Maria
AU  - Von Stumm M
AUID- ORCID: 0000-0001-9578-0430
AD  - Department of Cardiovascular Surgery, University Heart Center, University Medical 
      Center Hamburg-Eppendorf, Hamburg, Germany.
FAU - Petersen, J
AU  - Petersen J
AD  - Department of Cardiovascular Surgery, University Heart Center, University Medical 
      Center Hamburg-Eppendorf, Hamburg, Germany.
FAU - Westermann, D
AU  - Westermann D
AD  - Department of Cardiology, University Heart Center, University Medical Center 
      Hamburg-Eppendorf, Hamburg, Germany.
FAU - Reichenspurner, Hermann
AU  - Reichenspurner H
AD  - Department of Cardiovascular Surgery, University Heart Center, University Medical 
      Center Hamburg-Eppendorf, Hamburg, Germany.
FAU - Girdauskas, Evaldas
AU  - Girdauskas E
AD  - Department of Cardiovascular Surgery, University Heart Center, University Medical 
      Center Hamburg-Eppendorf, Hamburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191213
PL  - England
TA  - Expert Rev Cardiovasc Ther
JT  - Expert review of cardiovascular therapy
JID - 101182328
SB  - IM
MH  - Aortic Valve/surgery
MH  - Aortic Valve Insufficiency/*surgery
MH  - Aortic Valve Stenosis/*surgery
MH  - Bioprosthesis
MH  - Heart Valve Prosthesis
MH  - Heart Valve Prosthesis Implantation/methods
MH  - Humans
MH  - Middle Aged
MH  - Reoperation
MH  - Transcatheter Aortic Valve Replacement/adverse effects/*methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Mixed aortic valve disease
OT  - Ross procedure
OT  - congenital
OT  - mechanical aortic valve replacement
OT  - valve-in-valve transcatheter aortic valve replacement
EDAT- 2019/12/10 06:00
MHDA- 2020/03/03 06:00
CRDT- 2019/12/10 06:00
PHST- 2019/12/10 06:00 [pubmed]
PHST- 2020/03/03 06:00 [medline]
PHST- 2019/12/10 06:00 [entrez]
AID - 10.1080/14779072.2019.1702520 [doi]
PST - ppublish
SO  - Expert Rev Cardiovasc Ther. 2019 Dec;17(12):873-882. doi: 
      10.1080/14779072.2019.1702520. Epub 2019 Dec 13.