PMID- 31813806
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 216
DP  - 2020 Feb
TI  - Effects of the 5-HT2A and DRD3 genotypes on cortical morphology and functional 
      connectivity density in drug-naive first episode schizophrenia.
PG  - 213-221
LID - S0920-9964(19)30565-1 [pii]
LID - 10.1016/j.schres.2019.11.058 [doi]
AB  - The 5-hydroxytryptamine 2A receptor (5-HT2A) and dopamine D3 receptor (DRD3) have 
      been extensively studied as promising candidate genes for schizophrenia. Magnetic 
      resonance imaging studies have demonstrated that schizophrenia is associated with 
      widespread structural and functional abnormalities in the brain. Serotonin and 
      dopamine receptors play crucial roles in the development of the human cerebral 
      cortex and brain activity. However, how the 5-HT2A and DRD3 genes impact brain 
      structure and function in schizophrenia remains unknown. In the present study, we 
      investigated the main effect of disease state and the interaction effect between 
      disease state and genotype of these two genes on cortical volume, thickness, 
      surface area and functional connectivity density (FCD) in fifty-five drug-naive 
      first episode schizophrenia patients and fifty-three healthy controls. We found 
      that the differences in local FCD (lFCD) and global FCD (gFCD) between patients 
      and healthy controls were predominantly located in brain hub regions. The 
      significant interaction effects of disease state and 5-HT2A and DRD3 genes on 
      brain structure and function were mainly located in the temporal cortex. Our 
      findings may help to improve the understanding of the relationship between 5-HT2A 
      and DRD3 genotypes and schizophrenia pathogenesis.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Kang, Yafei
AU  - Kang Y
AD  - School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, 
      PR China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, 
      PR China.
FAU - Lv, Yahui
AU  - Lv Y
AD  - School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, 
      PR China.
FAU - Cai, Suping
AU  - Cai S
AD  - School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, 
      PR China.
FAU - Xu, Hanxiao
AU  - Xu H
AD  - School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, 
      PR China.
FAU - Wang, Jijun
AU  - Wang J
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai 200030, PR 
      China. Electronic address: jijunwang27@163.com.
FAU - Huang, Liyu
AU  - Huang L
AD  - School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, 
      PR China. Electronic address: huangly@mail.xidian.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191206
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (DRD3 protein, human)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Receptors, Dopamine D3)
SB  - IM
MH  - Cerebral Cortex/diagnostic imaging
MH  - Genotype
MH  - Humans
MH  - *Pharmaceutical Preparations
MH  - Receptors, Dopamine D3/genetics
MH  - *Schizophrenia/diagnostic imaging/genetics
OTO - NOTNLM
OT  - 5-Hydroxytryptamine 2A receptor
OT  - Cortical morphology
OT  - Dopamine D3 receptor
OT  - First episode schizophrenia
OT  - Functional connectivity density
COIS- Declaration of competing interest The authors declare that they have no conflicts 
      of interest.
EDAT- 2019/12/10 06:00
MHDA- 2021/06/22 06:00
CRDT- 2019/12/10 06:00
PHST- 2019/04/18 00:00 [received]
PHST- 2019/11/21 00:00 [revised]
PHST- 2019/11/29 00:00 [accepted]
PHST- 2019/12/10 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2019/12/10 06:00 [entrez]
AID - S0920-9964(19)30565-1 [pii]
AID - 10.1016/j.schres.2019.11.058 [doi]
PST - ppublish
SO  - Schizophr Res. 2020 Feb;216:213-221. doi: 10.1016/j.schres.2019.11.058. Epub 2019 
      Dec 6.