PMID- 31814049
OWN - NLM
STAT- MEDLINE
DCOM- 20201201
LR  - 20201201
IS  - 1432-1076 (Electronic)
IS  - 0340-6199 (Linking)
VI  - 179
IP  - 3
DP  - 2020 Mar
TI  - The occurrence of adverse events is associated with increased morbidity and 
      mortality in children admitted to a single pediatric intensive care unit.
PG  - 473-482
LID - 10.1007/s00431-019-03528-z [doi]
AB  - Healthcare can cause harm. The goal of this study is to evaluate the association 
      between the occurrence of adverse events (AEs) and morbidity-mortality in 
      critically ill children. A prospective cohort study was designed. All children 
      admitted to the Pediatric Intensive Care Unit (PICU) between August 2016 and July 
      2017 were followed. An AE was considered any harm associated with a 
      healthcare-related incident. AEs were identified in two steps: first, adverse 
      clinical incidents (ACI) were recognized through direct observation and active 
      surveillance by PICU physicians, and then the patient safety committee evaluated 
      every ACI to define which would be considered an AE. The outcome was hospital 
      morbidity-mortality. There were 467 ACI registered, 249 (53.31%) were considered 
      AEs and the rate was 4.27/100 patient days. From the 842 children included, 142 
      (16.86%) suffered AEs, 39 (4.63%) experienced morbidity-mortality: 33 (3.92%) 
      died, and 6 (0.71%) had morbidity. Multivariate analysis revealed that the 
      occurrence of AEs was significantly associated with morbidity-mortality, OR 5.70 
      (CI95% 2.58-12.58, p = 0.001). This association was independent of age and 
      severity of illness score.Conclusion: Experiencing AEs significantly increased 
      the risk of morbidity-mortality in this cohort of PICU children.What is Known:* 
      Many children suffer healthcare-associated harm during pediatric intensive care 
      hospitalization.What is New:* This prospective cohort study shows that 
      experiencing adverse events during pediatric intensive care hospitalization 
      significantly increases the risk of morbidity and mortality independent of age 
      and severity of illness at admission.
FAU - Eulmesekian, Pablo G
AU  - Eulmesekian PG
AUID- ORCID: 0000-0002-1607-8879
AD  - Pediatric Intensive Care Unit, Hospital Italiano de Buenos Aires, Peron 4190, CP 
      1181, Autonomous City of Buenos Aires, Argentina. 
      pablo.eulmesekian@hospitalitaliano.org.ar.
FAU - Alvarez, Juan P
AU  - Alvarez JP
AD  - Pediatric Intensive Care Unit, Hospital Italiano de Buenos Aires, Peron 4190, CP 
      1181, Autonomous City of Buenos Aires, Argentina.
FAU - Ceriani Cernadas, Jose M
AU  - Ceriani Cernadas JM
AD  - Patient Safety Committee|, Hospital Italiano de Buenos Aires, Autonomous City of 
      Buenos Aires, Argentina.
FAU - Perez, Augusto
AU  - Perez A
AD  - Pediatric Intensive Care Unit, Hospital Italiano de Buenos Aires, Peron 4190, CP 
      1181, Autonomous City of Buenos Aires, Argentina.
FAU - Berberis, Stefania
AU  - Berberis S
AD  - Pediatric Intensive Care Unit, Hospital Italiano de Buenos Aires, Peron 4190, CP 
      1181, Autonomous City of Buenos Aires, Argentina.
FAU - Kondratiuk, Yanel
AU  - Kondratiuk Y
AD  - Pediatric Intensive Care Unit, Hospital Italiano de Buenos Aires, Peron 4190, CP 
      1181, Autonomous City of Buenos Aires, Argentina.
LA  - eng
PT  - Journal Article
DEP - 20191208
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Critical Illness/therapy
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Iatrogenic Disease/*epidemiology
MH  - Intensive Care Units, Pediatric/*statistics & numerical data
MH  - Male
MH  - Medical Errors/*statistics & numerical data
MH  - Morbidity
MH  - Patient Safety/statistics & numerical data
MH  - Prospective Studies
MH  - Surgical Procedures, Operative/*adverse effects
OTO - NOTNLM
OT  - Adverse events
OT  - Children
OT  - Critical care
OT  - Morbidity
OT  - Mortality
OT  - Patient safety
EDAT- 2019/12/10 06:00
MHDA- 2020/12/02 06:00
CRDT- 2019/12/10 06:00
PHST- 2019/05/21 00:00 [received]
PHST- 2019/11/10 00:00 [accepted]
PHST- 2019/10/22 00:00 [revised]
PHST- 2019/12/10 06:00 [pubmed]
PHST- 2020/12/02 06:00 [medline]
PHST- 2019/12/10 06:00 [entrez]
AID - 10.1007/s00431-019-03528-z [pii]
AID - 10.1007/s00431-019-03528-z [doi]
PST - ppublish
SO  - Eur J Pediatr. 2020 Mar;179(3):473-482. doi: 10.1007/s00431-019-03528-z. Epub 
      2019 Dec 8.