PMID- 31814279
OWN - NLM
STAT- MEDLINE
DCOM- 20201125
LR  - 20201125
IS  - 1752-699X (Electronic)
IS  - 1752-6981 (Linking)
VI  - 14
IP  - 3
DP  - 2020 Mar
TI  - CMR-based heart deformation analysis for quantification of hemodynamics and right 
      ventricular dysfunction in patients with CTEPH.
PG  - 277-284
LID - 10.1111/crj.13128 [doi]
AB  - INTRODUCTION: Quantification of hemodynamics and right ventricular (RV) function 
      is crucial for pulmonary hypertension (PH). Cardiovascular magnetic 
      resonance-based heart deformation analysis (CMR-HDA) has been used to assess the 
      ventricular strain. OBJECTIVE: This study was to determine the correlation of 
      right ventricular longitudinal strain (RVLS) assessed with CMR-HDA with RV 
      function as well as hemodynamics in patients with chronic thromboembolic 
      pulmonary hypertension (CTEPH). METHODS: Thirty-six CTEPH patients were 
      prospectively included in this research. Each patients underwent CMR and right 
      heart catheterization (RHC). RVLS and RV ejection fraction (RVEF) was quantified 
      from cine images acquired with a retrospectively gated turbo FLASH gradient-echo 
      sequence. The late gadolinium enhancement (LGE) images were acquired using a 2D 
      inversion recovery phase-sensitive fast gradient-echo sequence. Hemodynamics were 
      determined with RHC. RESULTS: Right ventricular longitudinal strain measured with 
      CMR-HDA was -13.99 +/- 4.94%. Bland-Altman plots showed statistical agreement with 
      RVLS with low intra- and interobserver variability. RVLS correlated with serum 
      N-terminal-pro-B-type natriuretic peptide (r = 0.615, P < .001). RVLS inversely 
      correlated with RVEF (r = -0.699, P < .001), and it was positively correlated 
      with both RVESV (r = 0.664, P < .001) and myocardial the volume of LGE 
      (r = 0.447, P = .008). Receiver-operating characteristic (ROC) indicated that 
      RVLS values of >-14.20% could be used to predict RVEF <40% with a 100% 
      sensitivity and a 96.7% specificity. Hemodynamically, RVLS was positively 
      correlated with mean pulmonary artery pressure (r = 0.598, P < .001) and 
      pulmonary vascular resistance (r = 0.685, P < .001). CONCLUSION: Right 
      ventricular longitudinal strain assessed by CMR-HDA is a readily available and 
      reproducible parameters of RV function. RVLS >-14.20% suggests the presence of RV 
      dysfunction.
CI  - (c) 2019 John Wiley & Sons Ltd.
FAU - Tao, Xincao
AU  - Tao X
AD  - Department of Pulmonary and Critical Care Medicine, Center of Respiratory 
      Medicine, China-Japan Friendship Hospital, Beijing, China.
AD  - Chinese Academy of Medical Sciences, Graduate School of Peking Union Medical 
      College, Beijing, China.
FAU - Liu, Min
AU  - Liu M
AUID- ORCID: 0000-0003-1298-4441
AD  - Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
FAU - Liu, Weifang
AU  - Liu W
AD  - Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
FAU - Xie, Wanmu
AU  - Xie W
AD  - Department of Pulmonary and Critical Care Medicine, Center of Respiratory 
      Medicine, China-Japan Friendship Hospital, Beijing, China.
FAU - Wan, Jun
AU  - Wan J
AD  - Department of Pulmonary and Critical Care Medicine, Center of Respiratory 
      Medicine, China-Japan Friendship Hospital, Beijing, China.
FAU - Zhai, Zhenguo
AU  - Zhai Z
AUID- ORCID: 0000-0002-7096-8792
AD  - Department of Pulmonary and Critical Care Medicine, Center of Respiratory 
      Medicine, China-Japan Friendship Hospital, Beijing, China.
FAU - Wang, Chen
AU  - Wang C
AD  - Department of Pulmonary and Critical Care Medicine, Center of Respiratory 
      Medicine, China-Japan Friendship Hospital, Beijing, China.
AD  - Chinese Academy of Medical Sciences, Graduate School of Peking Union Medical 
      College, Beijing, China.
LA  - eng
GR  - PYBA1807/Beijing University of Chemical Technology-China-Japan Friendship 
      Hospital Research Project/
GR  - 7182149/Beijing Natural Science Foundation/
GR  - 81871328/National Natural Science Foundation of China/
GR  - Z181100001918034/Beijing Science and Technology Commission Pharmaceutical and 
      Technology Innovation Project/
GR  - 2018RC320013/Chinese Academy of Medical Sciences/
PT  - Journal Article
DEP - 20200105
PL  - England
TA  - Clin Respir J
JT  - The clinical respiratory journal
JID - 101315570
RN  - 0 (Contrast Media)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Cardiac Catheterization/methods
MH  - Chronic Disease
MH  - Contrast Media
MH  - Echocardiography/methods
MH  - Female
MH  - Gadolinium/administration & dosage
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Hypertension, Pulmonary/*diagnostic imaging/physiopathology
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/metabolism
MH  - Observer Variation
MH  - Peptide Fragments/metabolism
MH  - Pulmonary Embolism/complications/*diagnostic imaging/physiopathology
MH  - Pulmonary Wedge Pressure/physiology
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Stroke Volume/physiology
MH  - Vascular Resistance
MH  - Ventricular Dysfunction, Right/*diagnostic imaging/physiopathology
MH  - Ventricular Function, Right/physiology
OTO - NOTNLM
OT  - cardiovascular magnetic resonance
OT  - chronic thromboembolic pulmonary hypertension
OT  - heart deformation analysis
OT  - hemodynamics
OT  - right ventricular function
OT  - right ventricular longitudinal strain
EDAT- 2019/12/10 06:00
MHDA- 2020/11/26 06:00
CRDT- 2019/12/10 06:00
PHST- 2018/10/27 00:00 [received]
PHST- 2019/05/25 00:00 [revised]
PHST- 2019/12/04 00:00 [accepted]
PHST- 2019/12/10 06:00 [pubmed]
PHST- 2020/11/26 06:00 [medline]
PHST- 2019/12/10 06:00 [entrez]
AID - 10.1111/crj.13128 [doi]
PST - ppublish
SO  - Clin Respir J. 2020 Mar;14(3):277-284. doi: 10.1111/crj.13128. Epub 2020 Jan 5.