PMID- 31815297 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20210514 IS - 1398-9995 (Electronic) IS - 0105-4538 (Linking) VI - 75 IP - 5 DP - 2020 May TI - Development of the Angioedema Control Test-A patient-reported outcome measure that assesses disease control in patients with recurrent angioedema. PG - 1165-1177 LID - 10.1111/all.14144 [doi] AB - BACKGROUND: Recurrent angioedema (AE) is an important clinical problem in the context of chronic urticaria (mast cell mediator-induced), ACE-inhibitor intake and hereditary angioedema (both bradykinin-mediated). To help patients obtain control of their recurrent AE is a major treatment goal. However, a tool to assess control of recurrent AE is not yet available. This prompted us to develop such a tool, the Angioedema Control Test (AECT). METHODS: After a conceptional framework was developed for the AECT, a list of potential AECT items was generated by a combined approach of patient interviews, literature review and expert input. Subsequent item reduction was based on impact analysis, inter-item correlation, additional predefined criteria for item performance, and a review of the item selection process for content validity. Finally, an instruction section was generated, and an US-American-English version was developed by a structured translation process. RESULTS: A 4-item AECT with recall periods of 4 weeks and 3 months was developed based on 106 potential items tested in 97 patients with mast cell mediator-induced (n = 49) or bradykinin-mediated recurrent AE (n = 48). Eighty-four items were excluded based on impact analysis. The remaining 22 items could be further reduced by a method-mix of inter-item correlation, additional predefined criteria for item performance and review for content validity. CONCLUSIONS: The AECT is the first tool to assess disease control in recurrent AE patients. Its retrospective approach, its brevity and its simple scoring make the AECT ideally suited for clinical practice and trials. Its validity and reliability need to be determined in future independent studies. CI - (c) 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. FAU - Weller, Karsten AU - Weller K AUID- ORCID: 0000-0003-4437-0313 AD - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Donoso, Tamara AU - Donoso T AD - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Magerl, Markus AU - Magerl M AD - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Aygoren-Pursun, Emel AU - Aygoren-Pursun E AD - Department of Children and Adolescents, University Hospital Frankfurt, Goethe University, Frankfurt, Germany. FAU - Staubach, Petra AU - Staubach P AD - Department of Dermatology, University Medical Center Mainz, Mainz, Germany. FAU - Martinez-Saguer, Inmaculada AU - Martinez-Saguer I AD - HRZM Hemophilia Center Rhein Main, Morfelden-Walldorf, Germany. FAU - Hawro, Tomasz AU - Hawro T AD - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Altrichter, Sabine AU - Altrichter S AUID- ORCID: 0000-0001-9955-385X AD - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Krause, Karoline AU - Krause K AUID- ORCID: 0000-0001-9711-9654 AD - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Siebenhaar, Frank AU - Siebenhaar F AUID- ORCID: 0000-0003-4532-1644 AD - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Metz, Martin AU - Metz M AUID- ORCID: 0000-0002-4070-9976 AD - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Zuberbier, Torsten AU - Zuberbier T AUID- ORCID: 0000-0002-1466-8875 AD - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Freier, Denise AU - Freier D AD - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Maurer, Marcus AU - Maurer M AUID- ORCID: 0000-0002-4121-481X AD - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - Universitatsmedizin Berlin, Berlin, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20200306 PL - Denmark TA - Allergy JT - Allergy JID - 7804028 RN - S8TIM42R2W (Bradykinin) SB - IM MH - *Angioedema/diagnosis/epidemiology/etiology MH - Bradykinin MH - Humans MH - Patient Reported Outcome Measures MH - Reproducibility of Results MH - Retrospective Studies OTO - NOTNLM OT - AECT, angioedema OT - development OT - disease control OT - impact analysis OT - item selection EDAT- 2019/12/10 06:00 MHDA- 2021/05/15 06:00 CRDT- 2019/12/10 06:00 PHST- 2019/08/05 00:00 [received] PHST- 2019/10/25 00:00 [revised] PHST- 2019/11/18 00:00 [accepted] PHST- 2019/12/10 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] PHST- 2019/12/10 06:00 [entrez] AID - 10.1111/all.14144 [doi] PST - ppublish SO - Allergy. 2020 May;75(5):1165-1177. doi: 10.1111/all.14144. Epub 2020 Mar 6.