PMID- 31815841
OWN - NLM
STAT- MEDLINE
DCOM- 20200921
LR  - 20210201
IS  - 1532-0987 (Electronic)
IS  - 0891-3668 (Linking)
VI  - 39
IP  - 1
DP  - 2020 Jan
TI  - Prophylactic Paracetamol After Meningococcal B Vaccination Reduces 
      Postvaccination Fever and Septic Screens in Hospitalized Preterm Infants.
PG  - 78-80
LID - 10.1097/INF.0000000000002507 [doi]
AB  - BACKGROUND: Following the introduction of the 4CMenB (Bexsero, GlaxoSmithKline, 
      Rixensart, Belgium) vaccine against Meningococcal B into the UK vaccination 
      schedule, Public Health England advised paracetamol to be given prophylactically 
      with the vaccine. This was based on observations of increased postvaccination 
      febrile reactions in term infants. Evidence in preterm infants was lacking. We 
      aimed to evaluate whether (i) 4CmenB is associated with an increase in adverse 
      events (AEs) in the 48 hours after vaccination in preterm infants and (ii) the 
      impact of prophylactic paracetamol on AEs. METHODS: Retrospective case-note 
      review of preterm infants, within a UK level 3 neonatal unit, receiving first or 
      second 4CMenB vaccination, within 3 periods; (i) period 1 (pre-4CMenB): September 
      2014-September 2015; (ii) period 2 (4CMenB without prophylactic paracetamol): 
      September 2015-March 2016 and (iii) period 3 (4CMenB with prophylactic 
      paracetamol): June 2016-May 2018. Data were collected on a predefined list of 
      postvaccination AEs within 48 hours of vaccination: (i) number (%) of infants 
      with temperature >37.5 degrees C; (ii) highest temperature ( degrees C); (iii) number (%) of 
      infants receiving evaluation for sepsis and (iv) number (%) of infants receiving 
      intravenous antibiotics. RESULTS: Ninety-five vaccination episodes were included. 
      Compared with the pre-4CMenB (period 1), more infants developed temperature 
      >37.5 degrees C, needed partial septic screens and had intravenous antibiotics when 
      4CMenB was introduced without paracetamol prophylaxis (period 2). Paracetamol 
      prophylaxis (period 3) with 4CMenB resulted in fewer infants experiencing 
      postvaccination fever and antibiotic administration comparable to period 1. 
      CONCLUSIONS: 4CMenB is associated with AEs in hospitalized preterm infants. 
      Prophylactic paracetamol administration attenuates this.
FAU - Dubus, Magali
AU  - Dubus M
AD  - From the East Kent Hospitals University NHS Foundation Trust, William Harvey 
      Hospital, Ashford, Kent.
FAU - Ladhani, Shamez
AU  - Ladhani S
AD  - Immunisation, Hepatitis and Blood Safety Department, Public Health England.
FAU - Vasu, Vimal
AU  - Vasu V
AD  - From the East Kent Hospitals University NHS Foundation Trust, William Harvey 
      Hospital, Ashford, Kent.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (Meningococcal Vaccines)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/*therapeutic use
MH  - Female
MH  - Fever/epidemiology/etiology/*prevention & control
MH  - *Hospitalization
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Male
MH  - Meningitis, Meningococcal/*prevention & control
MH  - Meningococcal Vaccines/*adverse effects/immunology
MH  - Neisseria meningitidis, Serogroup B/*immunology
MH  - Premedication
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sepsis/*epidemiology/etiology/prevention & control
MH  - United Kingdom/epidemiology
MH  - Vaccination/*adverse effects
EDAT- 2019/12/10 06:00
MHDA- 2020/09/22 06:00
CRDT- 2019/12/10 06:00
PHST- 2019/12/10 06:00 [entrez]
PHST- 2019/12/10 06:00 [pubmed]
PHST- 2020/09/22 06:00 [medline]
AID - 00006454-202001000-00016 [pii]
AID - 10.1097/INF.0000000000002507 [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 2020 Jan;39(1):78-80. doi: 10.1097/INF.0000000000002507.