PMID- 31816239 OWN - NLM STAT- MEDLINE DCOM- 20200925 LR - 20200925 IS - 1944-8252 (Electronic) IS - 1944-8244 (Linking) VI - 12 IP - 1 DP - 2020 Jan 8 TI - Polydopamine-PEG-Folic Acid Conjugate Film Engineered TiO(2) Nanotube Arrays for Photoelectrochemical Sensing of Folate Binding Protein. PG - 1877-1884 LID - 10.1021/acsami.9b17630 [doi] AB - Serum-soluble folate binding protein (FBP) is an important tumor marker, and the development of a simple biosensing method is highly needed. In this work, a photoelectrochemical (PEC) biosensor for the detection of FBP was proposed based on the construction of an antifouling interface and the unique ligand-protein recognition. The PEC sensing platform was prepared by the biomimetic polydopamine (PDA) coating on TiO(2) nanotubes arrays (NTAs). A significant PEC enhancement effect was obtained due to the macroporous structures. Excellent antifouling performance was achieved by conjugation of amino-group-terminated 8-arm poly(ethylene glycol) (PEG). The incorporation of folic acid (FA) retains the antifouling property and shows recognition abilities toward FBP. The fabricated PEC biosensor shows good analytical performance. The combination of ligand-protein recognition and a PEC antifouling interface provides a good consideration for the development of FBP biosensors. FAU - Fan, Bobo AU - Fan B AD - Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering , University of Jinan , Jinan 250022 , People's Republic of China. FAU - Fan, Qi AU - Fan Q AD - Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering , University of Jinan , Jinan 250022 , People's Republic of China. FAU - Hu, Lulin AU - Hu L AD - Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering , University of Jinan , Jinan 250022 , People's Republic of China. FAU - Cui, Min AU - Cui M AD - Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering , University of Jinan , Jinan 250022 , People's Republic of China. FAU - Wang, Xueying AU - Wang X AD - Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering , University of Jinan , Jinan 250022 , People's Republic of China. FAU - Ma, Hongmin AU - Ma H AUID- ORCID: 0000-0002-7061-8944 AD - Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering , University of Jinan , Jinan 250022 , People's Republic of China. FAU - Wei, Qin AU - Wei Q AUID- ORCID: 0000-0002-3034-8046 AD - Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering , University of Jinan , Jinan 250022 , People's Republic of China. LA - eng PT - Journal Article DEP - 20191220 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 RN - 0 (Biomarkers, Tumor) RN - 0 (Indoles) RN - 0 (Polymers) RN - 0 (polydopamine) RN - 15FIX9V2JP (titanium dioxide) RN - 3WJQ0SDW1A (Polyethylene Glycols) RN - 935E97BOY8 (Folic Acid) RN - D1JT611TNE (Titanium) RN - EC 3.1.3.11 (FBP1 protein, human) RN - EC 3.1.3.11 (Fructose-Bisphosphatase) SB - IM MH - Biomarkers, Tumor/blood/*isolation & purification MH - *Biosensing Techniques MH - Folic Acid/chemistry/pharmacology MH - Fructose-Bisphosphatase/blood/isolation & purification MH - Humans MH - Indoles/chemistry MH - Nanotubes/chemistry MH - Neoplasms/*blood/pathology MH - Photochemical Processes MH - Polyethylene Glycols/chemistry MH - Polymers/chemistry MH - Titanium/chemistry OTO - NOTNLM OT - TiO2 nanotubes arrays OT - folate binding protein OT - folic acid OT - poly(ethylene glycol) OT - polydopamine EDAT- 2019/12/10 06:00 MHDA- 2020/09/26 06:00 CRDT- 2019/12/10 06:00 PHST- 2019/12/10 06:00 [pubmed] PHST- 2020/09/26 06:00 [medline] PHST- 2019/12/10 06:00 [entrez] AID - 10.1021/acsami.9b17630 [doi] PST - ppublish SO - ACS Appl Mater Interfaces. 2020 Jan 8;12(1):1877-1884. doi: 10.1021/acsami.9b17630. Epub 2019 Dec 20.