PMID- 31817238
OWN - NLM
STAT- MEDLINE
DCOM- 20200731
LR  - 20200731
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 8
IP  - 12
DP  - 2019 Dec 4
TI  - Role of Ceramidases in Sphingolipid Metabolism and Human Diseases.
LID - 10.3390/cells8121573 [doi]
LID - 1573
AB  - Human pathologies such as Alzheimer's disease, type 2 diabetes-induced insulin 
      resistance, cancer, and cardiovascular diseases have altered lipid homeostasis. 
      Among these imbalanced lipids, the bioactive sphingolipids ceramide and 
      sphingosine-1 phosphate (S1P) are pivotal in the pathophysiology of these 
      diseases. Several enzymes within the sphingolipid pathway contribute to the 
      homeostasis of ceramide and S1P. Ceramidase is key in the degradation of ceramide 
      into sphingosine and free fatty acids. In humans, five different ceramidases are 
      known-acid ceramidase, neutral ceramidase, and alkaline ceramidase 1, 2, and 
      3-which are encoded by five different genes (ASAH1, ASAH2, ACER1, ACER2, and 
      ACER3, respectively). Notably, the neutral ceramidase N-acylsphingosine 
      amidohydrolase 2 (ASAH2) shows considerable differences between humans and 
      animals in terms of tissue expression levels. Besides, the subcellular 
      localization of ASAH2 remains controversial. In this review, we sum up the 
      results obtained for identifying gene divergence, structure, subcellular 
      localization, and manipulating factors and address the role of ASAH2 along with 
      other ceramidases in human diseases.
FAU - Parveen, Farzana
AU  - Parveen F
AD  - Department of Medical Laboratory Science and Biotechnology, College of Health 
      Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
FAU - Bender, Daniel
AU  - Bender D
AD  - Institute of Biochemistry, Department of Chemistry, University of Cologne, 50674 
      Koln, Germany.
FAU - Law, Shi-Hui
AU  - Law SH
AD  - Department of Medical Laboratory Science and Biotechnology, College of Health 
      Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
FAU - Mishra, Vineet Kumar
AU  - Mishra VK
AD  - Department of Medical Laboratory Science and Biotechnology, College of Health 
      Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
FAU - Chen, Chih-Chieh
AU  - Chen CC
AUID- ORCID: 0000-0002-5844-8428
AD  - Institute of Medical Science and Technology, National Sun Yat-sen University, 
      Kaohsiung 80424, Taiwan.
FAU - Ke, Liang-Yin
AU  - Ke LY
AUID- ORCID: 0000-0002-2547-0987
AD  - Department of Medical Laboratory Science and Biotechnology, College of Health 
      Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
AD  - Center for Lipid Biosciences, Kaohsiung Medical University Hospital, Kaohsiung 
      80708, Taiwan.
AD  - Graduate Institute of Medicine, College of Medicine & Drug Development and Value 
      Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191204
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (Ceramides)
RN  - 0 (Sphingolipids)
RN  - EC 3.5.1.23 (Ceramidases)
SB  - IM
MH  - Alzheimer Disease/*metabolism
MH  - Ceramidases/genetics/*metabolism
MH  - Ceramides/metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Humans
MH  - Inflammatory Bowel Diseases/*metabolism
MH  - Sphingolipids/*metabolism
PMC - PMC6952831
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - ceramide accumulation
OT  - inflammatory bowel disease
OT  - insulin resistance
OT  - metabolic syndrome
OT  - neutral ceramidase
OT  - type 2 diabetes
COIS- The authors declare no conflict of interest.
EDAT- 2019/12/11 06:00
MHDA- 2020/08/01 06:00
PMCR- 2019/12/01
CRDT- 2019/12/11 06:00
PHST- 2019/10/29 00:00 [received]
PHST- 2019/12/03 00:00 [revised]
PHST- 2019/12/03 00:00 [accepted]
PHST- 2019/12/11 06:00 [entrez]
PHST- 2019/12/11 06:00 [pubmed]
PHST- 2020/08/01 06:00 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - cells8121573 [pii]
AID - cells-08-01573 [pii]
AID - 10.3390/cells8121573 [doi]
PST - epublish
SO  - Cells. 2019 Dec 4;8(12):1573. doi: 10.3390/cells8121573.