PMID- 31817701
OWN - NLM
STAT- MEDLINE
DCOM- 20200427
LR  - 20200427
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 24
DP  - 2019 Dec 6
TI  - Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via 
      Suppressing NF-kappaB Pathway.
LID - 10.3390/ijms20246164 [doi]
LID - 6164
AB  - To elucidate the effect of rice protein (RP) on the depression of inflammation, 
      growing and adult rats were fed with caseins and RP for 2 weeks. Compared with 
      casein, RP reduced hepatic accumulations of reactive oxygen species (ROS) and 
      nitro oxide (NO), and plasma activities of alanine transaminase (ALT) and 
      aspartate transaminase (AST) in growing and adult rats. Intake of RP led to 
      increased mRNA levels, and protein expressions of phosphoinositide 3 kinase 
      (PI3K), protein kinase B (Akt), nuclear factor-kappaB 1 (NF-alphaB1), 
      reticuloendotheliosis viral oncogene homolog A (RelA), tumor necrotic factor alpha 
      (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), inducible nitric oxide 
      synthase (iNOS), cyclooxygenase-2 (COX-2), and monocyte chemoattractant protein-1 
      (MCP-1) were decreased, whereas hepatic expressions of interleukin-10 (IL-10) and 
      heme oxygenase 1 (HO-1) were increased by RP. The activation of NF-kappaB was 
      suppressed by RP through upregulation of inhibitory kappaB alpha (IkappaBalpha), resulting in 
      decreased translocation of nuclear factor-kappaB 1 (p50) and RelA (p65) to the 
      nucleus in RP groups. The present study demonstrates that RP exerts an 
      anti-inflammatory effect to inhibit ROS-derived inflammation through suppression 
      of the NF-kappaB pathway in growing and adult rats. Results suggest that the 
      anti-inflammatory capacity of RP is independent of age.
FAU - Wang, Zhengxuan
AU  - Wang Z
AD  - Department of Food Science and Engineering, School of Chemistry and Chemical 
      Engineering, Harbin Institute of Technology, Harbin 150001, China.
FAU - Liang, Mingcai
AU  - Liang M
AD  - Department of Food Science and Engineering, School of Chemistry and Chemical 
      Engineering, Harbin Institute of Technology, Harbin 150001, China.
FAU - Li, Hui
AU  - Li H
AD  - Department of Food Science and Engineering, School of Chemistry and Chemical 
      Engineering, Harbin Institute of Technology, Harbin 150001, China.
FAU - Cai, Liang
AU  - Cai L
AD  - Department of Food Science and Engineering, School of Chemistry and Chemical 
      Engineering, Harbin Institute of Technology, Harbin 150001, China.
FAU - Yang, Lin
AU  - Yang L
AUID- ORCID: 0000-0002-1826-6064
AD  - Department of Food Science and Engineering, School of Chemistry and Chemical 
      Engineering, Harbin Institute of Technology, Harbin 150001, China.
LA  - eng
GR  - 31371755/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20191206
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Proteins)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.14.18 (Heme Oxygenase (Decyclizing))
RN  - EC 1.14.14.18 (Hmox1 protein, rat)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Cyclooxygenase 2/metabolism
MH  - Heme Oxygenase (Decyclizing)/metabolism
MH  - Interleukin-6/metabolism
MH  - Male
MH  - NF-kappa B/*metabolism
MH  - Nitric Oxide Synthase Type II/metabolism
MH  - Oryza/*chemistry
MH  - Plant Proteins/*pharmacology
MH  - Rats
MH  - Rats, Wistar
PMC - PMC6941109
OTO - NOTNLM
OT  - NF-kappaB
OT  - age
OT  - anti-inflammatory activity
OT  - rats
OT  - rice protein
COIS- The authors declare no conflict of interest.
EDAT- 2019/12/11 06:00
MHDA- 2020/04/28 06:00
PMCR- 2019/12/01
CRDT- 2019/12/11 06:00
PHST- 2019/10/05 00:00 [received]
PHST- 2019/12/03 00:00 [revised]
PHST- 2019/12/04 00:00 [accepted]
PHST- 2019/12/11 06:00 [entrez]
PHST- 2019/12/11 06:00 [pubmed]
PHST- 2020/04/28 06:00 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - ijms20246164 [pii]
AID - ijms-20-06164 [pii]
AID - 10.3390/ijms20246164 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Dec 6;20(24):6164. doi: 10.3390/ijms20246164.