PMID- 31817900
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240327
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 11
IP  - 12
DP  - 2019 Dec 7
TI  - A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with 
      Locally Incorporated Drug Depots.
LID - 10.3390/pharmaceutics11120661 [doi]
LID - 661
AB  - Here, we present a new hybrid additive manufacturing (AM) process to create drug 
      delivery systems (DDSs) with selectively incorporated drug depots. The matrix of 
      a DDS was generated by stereolithography (SLA), whereas the drug depots were 
      loaded using inkjet printing. The novel AM process combining SLA with inkjet 
      printing was successfully implemented in an existing SLA test setup. In the first 
      studies, poly(ethylene glycol) diacrylate-based specimens with integrated depots 
      were generated. As test liquids, blue and pink ink solutions were used. 
      Furthermore, bovine serum albumin labeled with Coomassie blue dye as a model drug 
      was successfully placed in a depot inside a DDS. The new hybrid AM process makes 
      it possible to place several drugs independently of each other within the matrix. 
      This allows adjustment of the release profiles of the drugs depending on the size 
      as well as the position of the depots in the DDS.
FAU - Konasch, Jan
AU  - Konasch J
AD  - Microfluidics, Faculty of Mechanical Engineering and Marine Technology, 
      University of Rostock, Justus-von-Liebig Weg 6, 18059 Rostock, Germany.
FAU - Riess, Alexander
AU  - Riess A
AD  - Microfluidics, Faculty of Mechanical Engineering and Marine Technology, 
      University of Rostock, Justus-von-Liebig Weg 6, 18059 Rostock, Germany.
FAU - Mau, Robert
AU  - Mau R
AD  - Microfluidics, Faculty of Mechanical Engineering and Marine Technology, 
      University of Rostock, Justus-von-Liebig Weg 6, 18059 Rostock, Germany.
FAU - Teske, Michael
AU  - Teske M
AD  - Institute for Biomedical Engineering, University Medical Center Rostock, 
      Friedrich-Barnewitz-Strasse 4, 18119 Rostock, Germany.
FAU - Rekowska, Natalia
AU  - Rekowska N
AD  - Institute for Biomedical Engineering, University Medical Center Rostock, 
      Friedrich-Barnewitz-Strasse 4, 18119 Rostock, Germany.
FAU - Eickner, Thomas
AU  - Eickner T
AD  - Institute for Biomedical Engineering, University Medical Center Rostock, 
      Friedrich-Barnewitz-Strasse 4, 18119 Rostock, Germany.
FAU - Grabow, Niels
AU  - Grabow N
AD  - Institute for Biomedical Engineering, University Medical Center Rostock, 
      Friedrich-Barnewitz-Strasse 4, 18119 Rostock, Germany.
AD  - Department LL&M, Interdisciplinary Faculty, University of Rostock, Rostock, 
      Albert-Einstein-Str. 25, 18059 Rostock, Germany.
FAU - Seitz, Hermann
AU  - Seitz H
AUID- ORCID: 0000-0003-3401-0090
AD  - Microfluidics, Faculty of Mechanical Engineering and Marine Technology, 
      University of Rostock, Justus-von-Liebig Weg 6, 18059 Rostock, Germany.
AD  - Department LL&M, Interdisciplinary Faculty, University of Rostock, Rostock, 
      Albert-Einstein-Str. 25, 18059 Rostock, Germany.
LA  - eng
GR  - SE 1807/6-1; TE1233/1-1/Deutsche Forschungsgemeinschaft/
PT  - Journal Article
DEP - 20191207
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC6956340
OTO - NOTNLM
OT  - drug delivery system
OT  - drug depot
OT  - hybrid additive manufacturing process
OT  - inkjet printing
OT  - poly(ethylene glycol) diacrylate (PEGDA)
OT  - stereolithography
OT  - time-controlled drug release
COIS- The authors declare no conflict of interest.
EDAT- 2019/12/11 06:00
MHDA- 2019/12/11 06:01
PMCR- 2019/12/01
CRDT- 2019/12/11 06:00
PHST- 2019/11/10 00:00 [received]
PHST- 2019/12/02 00:00 [revised]
PHST- 2019/12/04 00:00 [accepted]
PHST- 2019/12/11 06:00 [entrez]
PHST- 2019/12/11 06:00 [pubmed]
PHST- 2019/12/11 06:01 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - pharmaceutics11120661 [pii]
AID - pharmaceutics-11-00661 [pii]
AID - 10.3390/pharmaceutics11120661 [doi]
PST - epublish
SO  - Pharmaceutics. 2019 Dec 7;11(12):661. doi: 10.3390/pharmaceutics11120661.