PMID- 31818508
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20221207
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 87
DP  - 2020 Mar
TI  - Association of genetic variants within HLA-DR region with Parkinson's disease in 
      Taiwan.
PG  - 140.e13-140.e18
LID - S0197-4580(19)30391-4 [pii]
LID - 10.1016/j.neurobiolaging.2019.11.002 [doi]
AB  - Previous genome-wide association studies in Caucasians suggest genetic loci of 
      human leukocyte antigen (HLA)-DR region may be associated with Parkinson's 
      disease (PD). However, these gene-disease associations were limitedly reported in 
      Asian populations. Herein, we investigated the effects of 5 top PD-associated 
      genetic variants within HLA-DR region in Caucasians, including rs4248166, 
      rs9268515, rs2395163, rs75855844, and rs660895, by genotyping 486 Taiwanese 
      patients with PD and 473 age-matched control subjects. Although the association 
      between rs2395163 C allele and patients with PD demonstrated marginal 
      significance (odds ratio [OR] = 0.74, 95% CI: 0.55-0.99, p = 0.045). The 
      frequency of rs2395163 C allele (8.65%) in male patients with PD was 
      significantly lower than in male control subjects (14.02%; OR = 0.58, 95% CI: 
      0.39-0.88, p = 0.009). The genetic associations between patients with PD and 
      other tested genetic variants were negative. Although strong linkage 
      disequilibrium (rs4248166-rs9626515-s2395163 and rs9626515-rs660895) were 
      observed, the haplotype analysis did not find any significant risk-associated 
      allelic combinations. These results suggest a distinct genetic background within 
      HLA-DR region between Taiwanese and Caucasian patients with PD.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Chang, Kuo-Hsuan
AU  - Chang KH
AD  - Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University 
      College of Medicine, Taoyuan, Taiwan.
FAU - Wu, Yih-Ru
AU  - Wu YR
AD  - Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University 
      College of Medicine, Taoyuan, Taiwan.
FAU - Chen, Yi-Chun
AU  - Chen YC
AD  - Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University 
      College of Medicine, Taoyuan, Taiwan.
FAU - Fung, Hon-Chung
AU  - Fung HC
AD  - Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University 
      College of Medicine, Taoyuan, Taiwan.
FAU - Chen, Chiung-Mei
AU  - Chen CM
AD  - Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University 
      College of Medicine, Taoyuan, Taiwan. Electronic address: Chen@cgmh.org.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191109
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (HLA-DR Antigens)
SB  - IM
EIN - Neurobiol Aging. 2020 Jul;91:170. PMID: 32273150
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - Female
MH  - *Genetic Association Studies
MH  - *Genetic Variation
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*genetics
MH  - Taiwan
OTO - NOTNLM
OT  - Disease association
OT  - HLA-DR
OT  - Parkinson's disease
OT  - Polymorphism
OT  - rs2395163
OT  - rs4248166
OT  - rs660895
OT  - rs75855844
OT  - rs9268515
EDAT- 2019/12/11 06:00
MHDA- 2020/09/15 06:00
CRDT- 2019/12/11 06:00
PHST- 2019/02/21 00:00 [received]
PHST- 2019/11/01 00:00 [revised]
PHST- 2019/11/01 00:00 [accepted]
PHST- 2019/12/11 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2019/12/11 06:00 [entrez]
AID - S0197-4580(19)30391-4 [pii]
AID - 10.1016/j.neurobiolaging.2019.11.002 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2020 Mar;87:140.e13-140.e18. doi: 
      10.1016/j.neurobiolaging.2019.11.002. Epub 2019 Nov 9.