PMID- 31818946
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231027
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 116
IP  - 52
DP  - 2019 Dec 26
TI  - Persistent, bioaccumulative, and toxic properties of liquid crystal monomers and 
      their detection in indoor residential dust.
PG  - 26450-26458
LID - 10.1073/pnas.1915322116 [doi]
AB  - Liquid crystal monomers (LCMs) are used widely in liquid crystal displays (LCDs), 
      which are dramatically changing the world due to the provision of convenient 
      communication. However, there are essentially no published reports on the fate 
      and/or effects of LCMs in the environment. Of 362 currently produced LCMs, 87 
      were identified as persistent and bioaccumulative (P&B) chemicals, which 
      indicated that these chemicals would exhibit resistance to degradation and 
      exhibit mobility after entering the environment. Following exposure to mixtures 
      of LCM collected from 6 LCD devices, significant modulation of 5 genes, CYP1A4, 
      PDK4, FGF19, LBFABP, and THRSP, was observed in vitro. Modulation of expressions 
      of mRNAs coding for these genes has frequently been reported for toxic (T) 
      persistent organic pollutants (POPs). In LCM mixtures, 33 individual LCMs were 
      identified by use of mass spectrometry and screened for in 53 samples of dust 
      from indoor environments. LCMs were detectable in 47% of analyzed samples, and 17 
      of the 33 LCMs were detectable in at least 1 sample of dust. Based on chemical 
      properties, including P&B&T of LCMs and their ubiquitous detection in dust 
      samples, the initial screening information suggests a need for studies to 
      determine status and trends in concentrations of LCMs in various environmental 
      matrices as well as tissues of humans and wildlife. There is also a need for more 
      comprehensive in vivo studies to determine toxic effects and potencies of LCMs 
      during chronic, sublethal exposures.
FAU - Su, Huijun
AU  - Su H
AD  - Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School 
      of Environmental and Biological Engineering, Nanjing University of Science and 
      Technology, 210094 Nanjing, People's Republic of China.
FAU - Shi, Shaobo
AU  - Shi S
AD  - Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School 
      of Environmental and Biological Engineering, Nanjing University of Science and 
      Technology, 210094 Nanjing, People's Republic of China.
FAU - Zhu, Ming
AU  - Zhu M
AD  - Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School 
      of Environmental and Biological Engineering, Nanjing University of Science and 
      Technology, 210094 Nanjing, People's Republic of China.
FAU - Crump, Doug
AU  - Crump D
AD  - Environment and Climate Change Canada, National Wildlife Research Centre, 
      Carleton University, Ottawa, ON K1A 0H3, Canada.
FAU - Letcher, Robert J
AU  - Letcher RJ
AD  - Environment and Climate Change Canada, National Wildlife Research Centre, 
      Carleton University, Ottawa, ON K1A 0H3, Canada.
FAU - Giesy, John P
AU  - Giesy JP
AD  - Department of Veterinary Biomedical Sciences and Toxicology Centre, University of 
      Saskatchewan, Saskatoon, SK S7N5B3, Canada.
AD  - Department of Zoology, Michigan State University, East Lansing, MI 48824.
AD  - Center for Integrative Toxicology, Michigan State University, East Lansing, MI 
      48824.
FAU - Su, Guanyong
AU  - Su G
AD  - Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School 
      of Environmental and Biological Engineering, Nanjing University of Science and 
      Technology, 210094 Nanjing, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20191209
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
SB  - IM
PMC - PMC6936347
OTO - NOTNLM
OT  - bioaccumulation (B)
OT  - liquid crystal displays (LCDs)
OT  - liquid crystal monomers (LCMs)
OT  - persistence (P)
OT  - toxic (T)
COIS- The authors declare no competing interest.
EDAT- 2019/12/11 06:00
MHDA- 2019/12/11 06:01
PMCR- 2020/06/09
CRDT- 2019/12/11 06:00
PHST- 2019/12/11 06:00 [pubmed]
PHST- 2019/12/11 06:01 [medline]
PHST- 2019/12/11 06:00 [entrez]
PHST- 2020/06/09 00:00 [pmc-release]
AID - 1915322116 [pii]
AID - 201915322 [pii]
AID - 10.1073/pnas.1915322116 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26450-26458. doi: 
      10.1073/pnas.1915322116. Epub 2019 Dec 9.