PMID- 31819578
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 12
DP  - 2019
TI  - Urinary C-Peptide Creatinine Ratio as a Non-Invasive Tool for Identifying Latent 
      Autoimmune Diabetes in Adults (LADA).
PG  - 2531-2537
LID - 10.2147/DMSO.S229675 [doi]
AB  - PURPOSE: Latent autoimmune diabetes in adults (LADA) is a slowly progressing form 
      of immune-mediated diabetes that combines phenotypical features of both type 2 
      diabetes mellitus (T2DM) and type 1 diabetes mellitus (T1DM), meaning that 
      accurate and early diagnosis of this subtype of diabetes is critical for optimal 
      long-term management. Urinary C-peptide creatinine ratio (UCPCR) represents a 
      non-invasive and practical method for assessing endogenous insulin production to 
      facilitate diabetes classification. However, no study to date has reported the 
      use of UCPCR in identifying LADA. PATIENTS AND METHODS: A total of 574 subjects 
      were included in our study (42 LADA, 61 T1DM, 471 T2DM). All participants were 
      evaluated for UCPCR and underwent clinical and laboratory evaluations. UCPCR was 
      compared among different subtypes of diabetes using multinomial regression 
      analysis, and a receiver operating characteristic (ROC) curve was used to 
      identify its performance in diagnosing LADA. RESULTS: UCPCR was lower in LADA 
      (0.4+/-0.6 nmol/mmol) compared with T2DM (1.2+/-0.9 nmol/mmol), but higher than in 
      T1DM (0.2+/-0.3 nmol/mmol) (p<0.05). The association between UCPCR and LADA 
      remained significant after adjusting for gender, age, age at diagnosis, body mass 
      index, high-density lipoprotein cholesterol, and triglyceride (OR, 95% confidence 
      interval (CI), 0.29 (0.09, 0.95)). The ROC curve revealed an area under the curve 
      of 0.835 (95% CI (0.742-0.928), p<0.001). The cut-off point for UCPCR </= 0.46 
      nmol/mmol was 82.1% for sensitivity and 76.7% for specificity in the diagnosis of 
      LADA. CONCLUSION: UCPCR may represent a non-invasive, simple, and practical 
      measurement of insulin secretion for early discrimination of LADA in routine 
      clinical practice.
CI  - (c) 2019 Liu et al.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing, People's Republic of China.
FAU - Huang, Xingquan
AU  - Huang X
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing, People's Republic of China.
AD  - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of 
      Hebei North University, Zhangjiakou, Hebei, People's Republic of China.
FAU - Zhang, Xiuying
AU  - Zhang X
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing, People's Republic of China.
FAU - Cai, Xiaoling
AU  - Cai X
AUID- ORCID: 0000-0002-7881-0543
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing, People's Republic of China.
FAU - Han, Xueyao
AU  - Han X
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing, People's Republic of China.
FAU - Zhou, Xianghai
AU  - Zhou X
AUID- ORCID: 0000-0003-2340-6727
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing, People's Republic of China.
FAU - Chen, Ling
AU  - Chen L
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing, People's Republic of China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing, People's Republic of China.
FAU - Gong, Siqian
AU  - Gong S
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing, People's Republic of China.
FAU - Wang, Yanai
AU  - Wang Y
AUID- ORCID: 0000-0002-8190-0152
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing, People's Republic of China.
FAU - Ji, Linong
AU  - Ji L
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Beijing, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20191202
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC6896913
OTO - NOTNLM
OT  - autoimmune diabetes
OT  - non-invasive measurement
OT  - urinary C-peptide
OT  - beta-cell function
COIS- The authors report no conflicts of interest in this work.
EDAT- 2019/12/11 06:00
MHDA- 2019/12/11 06:01
PMCR- 2019/12/02
CRDT- 2019/12/11 06:00
PHST- 2019/09/03 00:00 [received]
PHST- 2019/11/23 00:00 [accepted]
PHST- 2019/12/11 06:00 [entrez]
PHST- 2019/12/11 06:00 [pubmed]
PHST- 2019/12/11 06:01 [medline]
PHST- 2019/12/02 00:00 [pmc-release]
AID - 229675 [pii]
AID - 10.2147/DMSO.S229675 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2019 Dec 2;12:2531-2537. doi: 10.2147/DMSO.S229675. 
      eCollection 2019.