PMID- 31820181
OWN - NLM
STAT- MEDLINE
DCOM- 20201110
LR  - 20221207
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 65
IP  - 8
DP  - 2020 Aug
TI  - Symptoms Suggestive of Gastroparesis in a Community-Based Cohort of European 
      Americans and African Americans with Type 2 Diabetes Mellitus.
PG  - 2321-2330
LID - 10.1007/s10620-019-05974-z [doi]
AB  - BACKGROUND: Although gastroparesis is seen in patients with type 2 diabetes 
      mellitus (T2DM), the prevalence of symptoms suggestive of gastroparesis in 
      patients with T2DM is unknown, particularly among African Americans. AIMS: To 
      determine the prevalence of symptoms associated with gastroparesis in a large 
      community-based population of European Americans and African Americans with T2DM. 
      METHODS: Individuals with T2DM in the Diabetes Heart Study were asked to complete 
      the gastroparesis cardinal symptom index (GCSI) and other GI-related 
      questionnaires. GCSI total score >/= 18 represented moderate or worse symptoms 
      suggestive of gastroparesis. RESULTS: A total of 1253 participants (700 female, 
      553 male) completed the GCSI: 750 were European American and 503 African 
      American. GCSI scores >/= 18 were recorded in 72 participants: 38 (5%) of European 
      Americans and 34 (7%) of African Americans. The average GCSI was 24.1 in European 
      Americans and 24.6 in African Americans, indicating moderate to severe symptoms. 
      Compared to European Americans with GCSI scores >/= 18, African Americans were 
      younger (59.4 vs. 53.3 years, p = 0.004), had earlier onset of T2DM (46.3 vs. 
      40.1 years, p = 0.01), higher HbA1c (7.6 vs. 9.1, p = 0.0009), underwent fewer 
      upper endoscopies (55.3% vs. 26.5%, p = 0.02), and had more anxiety and 
      depression (p < 0.001). CONCLUSIONS: Moderate or greater symptoms suggestive of 
      gastroparesis are present in 5-7% of European and African American patients with 
      T2DM in community-based populations. Symptoms suggestive of gastroparesis may be 
      underappreciated in patients with T2DM and account for upper gastrointestinal 
      symptoms, unexplained glycemic control issues, and decreased quality of life.
FAU - Brown, Landon K
AU  - Brown LK
AD  - Department of Internal Medicine, Wake Forest School of Medicine, 1 Medical Center 
      Blvd, Winston-Salem, NC, 27157, USA. landon.brown526@gmail.com.
FAU - Xu, Jianzhao
AU  - Xu J
AD  - Department of Biochemistry and Center for Genomics, Wake Forest School of 
      Medicine, 1 Medical Center Blvd, Winston-Salem, NC, 27157, USA.
FAU - Freedman, Barry I
AU  - Freedman BI
AD  - Section on Nephrology, Wake Forest School of Medicine, 1 Medical Center Blvd, 
      Winston-Salem, NC, 27157, USA.
FAU - Hsu, Fang-Chi
AU  - Hsu FC
AD  - Department of Biochemistry and Center for Genomics, Wake Forest School of 
      Medicine, 1 Medical Center Blvd, Winston-Salem, NC, 27157, USA.
FAU - Bowden, Donald W
AU  - Bowden DW
AD  - Department of Biochemistry and Center for Genomics, Wake Forest School of 
      Medicine, 1 Medical Center Blvd, Winston-Salem, NC, 27157, USA.
FAU - Koch, Kenneth L
AU  - Koch KL
AD  - Section of Gastroenterology, Wake Forest School of Medicine, 1 Medical Center 
      Blvd, Winston-Salem, NC, 27157, USA.
LA  - eng
GR  - R01 HL92301 (DWB)/NH/NIH HHS/United States
GR  - R01 HL67348 (DWB)/NH/NIH HHS/United States
GR  - R01 HL067348/HL/NHLBI NIH HHS/United States
GR  - R01 DK071891/DK/NIDDK NIH HHS/United States
GR  - R01 HL092301/HL/NHLBI NIH HHS/United States
GR  - R01 DK071891 (BIF)/NH/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20191209
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
SB  - IM
MH  - Black or African American/statistics & numerical data
MH  - Aged
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Gastroparesis/*epidemiology/etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - North Carolina/epidemiology
MH  - Prevalence
MH  - Severity of Illness Index
MH  - White People/statistics & numerical data
PMC - PMC9135394
MID - NIHMS1800781
OTO - NOTNLM
OT  - Community-based population
OT  - Gastroparesis
OT  - Gastroparesis cardinal symptom index
OT  - Type 2 diabetes mellitus
COIS- Conflict of interest All authors have no conflicts of interest or financial 
      disclosures to disclose.
EDAT- 2019/12/11 06:00
MHDA- 2020/11/11 06:00
PMCR- 2022/05/26
CRDT- 2019/12/11 06:00
PHST- 2019/03/26 00:00 [received]
PHST- 2019/11/22 00:00 [accepted]
PHST- 2019/12/11 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2019/12/11 06:00 [entrez]
PHST- 2022/05/26 00:00 [pmc-release]
AID - 10.1007/s10620-019-05974-z [pii]
AID - 10.1007/s10620-019-05974-z [doi]
PST - ppublish
SO  - Dig Dis Sci. 2020 Aug;65(8):2321-2330. doi: 10.1007/s10620-019-05974-z. Epub 2019 
      Dec 9.