PMID- 31820331
OWN - NLM
STAT- MEDLINE
DCOM- 20210128
LR  - 20210128
IS  - 1179-2000 (Electronic)
IS  - 1177-1062 (Linking)
VI  - 24
IP  - 1
DP  - 2020 Feb
TI  - Clinical Features and Genetic Polymorphism in Chinese Patients with Erythrodermic 
      Psoriasis in a Single Dermatologic Clinic.
PG  - 85-93
LID - 10.1007/s40291-019-00441-x [doi]
AB  - BACKGROUND: Erythrodermic psoriasis (EP) is a rare variant of psoriasis that 
      involves more complications and poorer biologic drug survival than plaque-type 
      psoriasis vulgaris (PV). No prior study has explored human leukocyte antigen 
      (HLA) or other genetic polymorphisms in patients with EP. OBJECTIVES: Our 
      objective was to describe the clinical features, comorbidities, and HLA 
      polymorphisms among Chinese patients with EP. METHODS: We enrolled consecutive 
      patients with EP from our clinic, with EP defined as generalized confluent 
      erythematous thin plaques covering at least 80% body surface area. Patients were 
      categorized as having primary or secondary EP. Aggravating factors, comorbidities 
      including psoriatic arthritis, family history of psoriasis, age of onset, and 
      treatment history were also identified. Genetic studies were performed for HLA-C 
      and HLA-DRB1, and the results were compared with those from a healthy population 
      and patients with PV. RESULTS: Of the 63 included patients, the male to female 
      ratio was 2.71:1. Five (7.9%) patients had primary EP, and 58 (92.1%) had 
      secondary EP. Genotyping of HLA-C and HLA-DRB1 was available in 61 and 58 
      subjects, respectively. HLA-C*0102 was the most frequent HLA-C allele (34.4%), 
      followed by HLA-C*0702 (18.0%). The frequency of HLA-C*0602 allele (4.1%) was 
      lower than in patients with plaque-type psoriasis (4.1 vs. 16.3%, corrected p 
      value [P(c)] = 0.02) and similar to that in the healthy population in Taiwan. The 
      most frequent HLA-DRB1 allele was HLA-DRB1*0901 (20.7%), followed by 
      HLA-DRB1*0803 (13.8%). An increased prevalence of psoriatic arthritis (61.9%) and 
      higher male predominance were also noted in comparison with PV. CONCLUSIONS: 
      There are HLA differences in Chinese patients with EP compared with patients with 
      PV. The incidence of psoriatic arthritis is also higher. The implications of the 
      above findings await further investigation.
FAU - Lo, Yang
AU  - Lo Y
AD  - Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.
FAU - Chiu, Hsien-Yi
AU  - Chiu HY
AD  - Department of Dermatology, Hsin-Chu Branch, National Taiwan University Hospital, 
      Hsin-Chu, Taiwan.
FAU - Tsai, Tsen-Fang
AU  - Tsai TF
AUID- ORCID: 0000-0002-1498-1474
AD  - Department of Dermatology, National Taiwan University Hospital and National 
      Taiwan University College of Medicine, Taipei, Taiwan. tftsai@yahoo.com.
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Mol Diagn Ther
JT  - Molecular diagnosis & therapy
JID - 101264260
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Biomarkers
MH  - Comorbidity
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Association Studies/methods
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Phenotype
MH  - *Polymorphism, Genetic
MH  - Psoriasis/*diagnosis/*etiology/therapy
MH  - Retrospective Studies
EDAT- 2019/12/11 06:00
MHDA- 2021/01/29 06:00
CRDT- 2019/12/11 06:00
PHST- 2019/12/11 06:00 [pubmed]
PHST- 2021/01/29 06:00 [medline]
PHST- 2019/12/11 06:00 [entrez]
AID - 10.1007/s40291-019-00441-x [pii]
AID - 10.1007/s40291-019-00441-x [doi]
PST - ppublish
SO  - Mol Diagn Ther. 2020 Feb;24(1):85-93. doi: 10.1007/s40291-019-00441-x.