PMID- 31820666
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20210705
IS  - 1541-2563 (Electronic)
IS  - 1541-2563 (Linking)
VI  - 17
IP  - 1
DP  - 2020 Feb
TI  - Acute Phase Proteins as Predictors of Survival in Patients With Acute 
      Exacerbation of Chronic Obstructive Pulmonary Disease Requiring Mechanical 
      Ventilation.
PG  - 22-28
LID - 10.1080/15412555.2019.1698019 [doi]
AB  - Few studies have tried to assess prognostic variables in chronic obstructive 
      pulmonary disease (COPD) patients requiring mechanical ventilation (MV). We 
      evaluated serum C reactive protein, (CRP) pre-albumin (PA) and transferrin (TR) 
      levels in AE-COPD patients requiring MV as prognostic markers of in hospital 
      mortality. 93 AE-COPD patients on MV were evaluated. Detailed clinical evaluation 
      was done daily. Serum CRP & PA were measured on admission, 3rd, 8th and 16th day; 
      TR was measured on admission, 8th and 16th day. Demographics, baseline 
      parameters, CRP, PA and TR were correlated with mortality. Of 93 patients, 49 
      (52.69%) survived whereas 44 patients (47.31%) died. APACHE II, serum urea & 
      albumin were similar in survivors & non-survivors. Baseline CRP (>/=10.5 mg/dl) had 
      sensitivity of 60.5%, specificity of 60.2%, with area under curve (AUC) of 0.62 
      as predictor of mortality. CRP (>/=7 mg/dl) on day 3 had sensitivity (65.5%) and 
      specificity (63.3%) with AUC 0.70 as predictor of mortality. Baseline serum 
      prealbumin was 11.00 (0.09-29.26) mg/dl, and similar in survivors & non-survivors 
      (p = 0.7). Prealbumin at day 8 (n = 50) < 13.5 mg/dl had sensitivity 54.6%, and 
      specificity 51.4% with AUC 0.54 (95% CI 0.34-0.75) as predictor of mortality. 
      Transferrin at day 8 (n = 50) of <148.9 had sensitivity 63.4% and specificity 
      61.4% with AUC 0.61 with respect to mortality. High CRP levels at baseline, 
      persistently elevated CRP (on day 3) may predict mortality in AE-COPD patients 
      requiring MV. Further studies are required to establish prognostic variables in 
      this patient population.
FAU - Sneh, Arora
AU  - Sneh A
AD  - Department of Pulmonary Medicine and Sleep Disorders, All India Institute of 
      Medical Sciences, New Delhi, India.
FAU - Pawan, Tiwari
AU  - Pawan T
AUID- ORCID: 0000-0002-5136-4221
AD  - Department of Pulmonary Medicine and Sleep Disorders, All India Institute of 
      Medical Sciences, New Delhi, India.
FAU - Randeep, Guleria
AU  - Randeep G
AD  - Department of Pulmonary Medicine and Sleep Disorders, All India Institute of 
      Medical Sciences, New Delhi, India.
FAU - Anant, Mohan
AU  - Anant M
AD  - Department of Pulmonary Medicine and Sleep Disorders, All India Institute of 
      Medical Sciences, New Delhi, India.
FAU - Mani, Kalaivani
AU  - Mani K
AD  - Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Hadda, Vijay
AU  - Hadda V
AUID- ORCID: 0000-0001-5820-3685
AD  - Department of Pulmonary Medicine and Sleep Disorders, All India Institute of 
      Medical Sciences, New Delhi, India.
FAU - Madan, Karan
AU  - Madan K
AD  - Department of Pulmonary Medicine and Sleep Disorders, All India Institute of 
      Medical Sciences, New Delhi, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191210
PL  - England
TA  - COPD
JT  - COPD
JID - 101211769
RN  - 0 (Prealbumin)
RN  - 0 (Transferrin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Area Under Curve
MH  - C-Reactive Protein/*metabolism
MH  - Cigarette Smoking
MH  - Disease Progression
MH  - Female
MH  - Forced Expiratory Volume
MH  - *Hospital Mortality
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Prealbumin/*metabolism
MH  - Prognosis
MH  - Pulmonary Disease, Chronic 
      Obstructive/*metabolism/mortality/physiopathology/therapy
MH  - *Respiration, Artificial
MH  - Severity of Illness Index
MH  - Transferrin/*metabolism
OTO - NOTNLM
OT  - Acute phase reactants
OT  - COPD acute exacerbation
OT  - CRP
OT  - prognosis in AE COPD
EDAT- 2019/12/11 06:00
MHDA- 2021/07/06 06:00
CRDT- 2019/12/11 06:00
PHST- 2019/12/11 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2019/12/11 06:00 [entrez]
AID - 10.1080/15412555.2019.1698019 [doi]
PST - ppublish
SO  - COPD. 2020 Feb;17(1):22-28. doi: 10.1080/15412555.2019.1698019. Epub 2019 Dec 10.