PMID- 31821064
OWN - NLM
STAT- MEDLINE
DCOM- 20210107
LR  - 20210107
IS  - 1744-5078 (Electronic)
IS  - 0927-3948 (Linking)
VI  - 28
IP  - 2
DP  - 2020
TI  - Efficacy and Safety of Interferon Alpha 2A and Pegylated Interferon Alpha 2A in 
      Inflammatory Macular Edema.
PG  - 329-336
LID - 10.1080/09273948.2019.1604001 [doi]
AB  - Purpose: The aim of this study was to further explore the efficacy and safety of 
      interferon-alpha in refractory non-infectious inflammatory macular edema and to 
      compare interferon-alpha2a and pegylated interferon-alpha2b.Methods: 34 patients with 
      refractory non-infectious uveitic macular edemaunder interferon-alpha were 
      retrospectively reviewed.Results: Mean baseline best-corrected visual 
      acuityimproved from 0.55 logMar to 0.37 logMAR (P < 0.001) at month (M) 1 and 
      0.40 logMAR (P < 0.001) at M6. The mean baseline CMT decreased from 554 microm to 367 
      microm (P < 0.001) at M1 and 394 microm (P < 0.001) at M6. Clinical adverse effects (AEs) 
      were observed in a third of patients, leading to treatment discontinuation 
      because of frequent mild AEs and few severe AE. No statistically significant 
      difference was found between both molecules.Conclusions: Anatomically and 
      functionally, interferon-alpha was rapidly effective despite a low dosage regimen and 
      no difference in efficacy and tolerance was observed between interferon-alpha2a and 
      pegylated interferon-alpha2b.
FAU - Couret, Chloe
AU  - Couret C
AD  - Department of Ophthalmology, Nantes University Hospital, Nantes, France.
FAU - Servant, Marion
AU  - Servant M
AD  - Department of Ophthalmology, Nantes University Hospital, Nantes, France.
FAU - Lebranchu, Pierre
AU  - Lebranchu P
AD  - Department of Ophthalmology, Nantes University Hospital, Nantes, France.
FAU - Hamidou, Mohamed
AU  - Hamidou M
AD  - Department of Internal Medicine, Nantes University Hospital, Nantes, France.
FAU - Weber, Michel
AU  - Weber M
AD  - Department of Ophthalmology, Nantes University Hospital, Nantes, France.
LA  - eng
PT  - Journal Article
DEP - 20191210
PL  - England
TA  - Ocul Immunol Inflamm
JT  - Ocular immunology and inflammation
JID - 9312169
RN  - 0 (Interferon-alpha)
RN  - 0 (Recombinant Proteins)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - Q46947FE7K (peginterferon alfa-2a)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Interferon-alpha/*administration & dosage
MH  - Macular Edema/diagnosis/*drug therapy/etiology
MH  - Male
MH  - Middle Aged
MH  - Polyethylene Glycols/*administration & dosage
MH  - Recombinant Proteins/administration & dosage
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/methods
MH  - Treatment Outcome
MH  - Uveitis/*complications/diagnosis
MH  - *Visual Acuity
MH  - Young Adult
OTO - NOTNLM
OT  - Efficacy and safety
OT  - interferon
OT  - refractory macular edema
OT  - uveitis
EDAT- 2019/12/11 06:00
MHDA- 2021/01/08 06:00
CRDT- 2019/12/11 06:00
PHST- 2019/12/11 06:00 [pubmed]
PHST- 2021/01/08 06:00 [medline]
PHST- 2019/12/11 06:00 [entrez]
AID - 10.1080/09273948.2019.1604001 [doi]
PST - ppublish
SO  - Ocul Immunol Inflamm. 2020;28(2):329-336. doi: 10.1080/09273948.2019.1604001. 
      Epub 2019 Dec 10.