PMID- 31821683
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1552-4833 (Electronic)
IS  - 1552-4825 (Linking)
VI  - 182
IP  - 2
DP  - 2020 Feb
TI  - Fetoplacental ratios in stillbirths and second trimester miscarriages.
PG  - 322-327
LID - 10.1002/ajmg.a.61426 [doi]
AB  - An abnormal fetoplacental (F/P) ratio is a risk factor for poor pregnancy 
      outcomes including fetal death, but studies of F/P ratio among stillbirths are 
      limited. In the Wisconsin Stillbirth Service Program cohort of second and third 
      trimester fetal deaths, 1,022 were at >/=24 weeks with data on fetal and placental 
      weight. Comparison with data for viable infants of the same gestational ages 
      (GAs) showed that the F/P ratio increases more rapidly with GA for stillbirths 
      than for viable infants. While placentas of stillborn infants are small at all 
      GA, weights of deceased fetuses are lowest early in the second trimester, 
      becoming nearly normal by term. Excess high F/P ratios are noted at all GAs, 
      increasing toward term, while low ratios are frequent at early gestation but rare 
      near term. Analysis by cause of death shows that F/P ratios are markedly elevated 
      for placental and maternal causes (about 50% above the 90th centile), somewhat 
      elevated for cord accidents, non-hydropic fetal, and unknown causes (about 1/3 
      above the 90th centile), and variable with 40% below the 10th centile for 
      hydropic stillbirths. Across all causes and GAs, placental weights are more 
      abnormal than fetal weights, suggesting that diminished placental function may 
      contribute to fetal demise even when non-placental causes (e.g., premature 
      membrane rupture, cord accidents, and chromosomal disorders) are identified. 
      About half of all stillbirths have abnormal F/P ratios, suggesting that 
      improvements in prenatal assessment of placental size and function might aid in 
      identifying pregnancies at risk for demise; unfortunately, therapeutic options 
      for ongoing pregnancies with diminished placental function remain limited.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - McPherson, Elizabeth
AU  - McPherson E
AUID- ORCID: 0000-0002-1774-7341
AD  - Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, 
      Wisconsin.
LA  - eng
PT  - Journal Article
DEP - 20191210
PL  - United States
TA  - Am J Med Genet A
JT  - American journal of medical genetics. Part A
JID - 101235741
SB  - IM
MH  - Abortion, Spontaneous/diagnosis/epidemiology/*physiopathology
MH  - Adult
MH  - Female
MH  - Fetal Death
MH  - Fetal Weight/physiology
MH  - Fetus/*physiopathology
MH  - Gestational Age
MH  - Humans
MH  - Placenta/*physiopathology
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Pregnancy Trimester, Second
MH  - Risk Factors
MH  - Stillbirth/*epidemiology
MH  - Tympanic Membrane Perforation/diagnosis/epidemiology/physiopathology
OTO - NOTNLM
OT  - fetal death
OT  - fetoplacental ratio
OT  - miscarriage
OT  - stillbirth
EDAT- 2019/12/11 06:00
MHDA- 2021/01/12 06:00
CRDT- 2019/12/11 06:00
PHST- 2018/12/13 00:00 [received]
PHST- 2019/10/28 00:00 [revised]
PHST- 2019/10/29 00:00 [accepted]
PHST- 2019/12/11 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2019/12/11 06:00 [entrez]
AID - 10.1002/ajmg.a.61426 [doi]
PST - ppublish
SO  - Am J Med Genet A. 2020 Feb;182(2):322-327. doi: 10.1002/ajmg.a.61426. Epub 2019 
      Dec 10.