PMID- 31823526
OWN - NLM
STAT- MEDLINE
DCOM- 20201210
LR  - 20210110
IS  - 2050-4527 (Electronic)
IS  - 2050-4527 (Linking)
VI  - 8
IP  - 1
DP  - 2020 Mar
TI  - Atopy patch tests may identify patients at risk for systemic contact dermatitis.
PG  - 24-29
LID - 10.1002/iid3.280 [doi]
AB  - BACKGROUND: A subset of patients with positive patch tests demonstrates systemic 
      contact dermatitis (SCD) upon ingestion or inhalation of the allergen. Concern 
      has been raised about the use of patch tests for protein allergens (APTs) to 
      detect SCD in atopic dermatitis (AD) patients. METHODS: We present atopy patch 
      test (APT) data for 97 people. We reviewed APTs and tests for antigen-specific 
      immunoglobulin E (IgE) to the same allergen in pediatric AD patients. We compared 
      the frequency of APTs as a function of age in AD patients. To study the irritancy 
      potential of APTs, we prospectively tested consenting non-AD dermatitis patients 
      undergoing evaluation for allergic contact dermatitis and healthy controls to an 
      APT panel. RESULTS: APT demonstrated fewer positive results than serum-specific 
      IgE or skin prick tests to the same allergen. Positive APT to food was more 
      common in children under 3 years, whereas positive APT to aeroallergens were more 
      common in teens and adults. Only positive APTs to dust mite were significantly 
      more common positive in subjects without AD. CONCLUSION: Our aggregate findings 
      suggest that most APTs, but not dust mite, behave like conventional patch tests 
      to low-potency allergens. They are more likely to be positive in patients with 
      chronically inflamed skin and to identify allergens that cause SCD. The higher 
      prevalence of APT positivity to foods in young children is consistent with food 
      allergy as a trigger of AD (also known as SCD) being more common in children than 
      adults. Positive APTs define patients who may have SCD; negative APTs may guide 
      elimination diets.
CI  - (c) 2019 The Authors. Immunity, Inflammation and Disease published by John Wiley & 
      Sons Ltd.
FAU - Pootongkam, Suwimon
AU  - Pootongkam S
AD  - Department of Dermatology, University Hospitals Cleveland Medical Center, Case 
      Western Reserve University, Cleveland, Ohio.
FAU - Havele, Sonia A
AU  - Havele SA
AD  - Case Western Reserve University School of Medicine, Cleveland, Ohio.
FAU - Orillaza, Hanna
AU  - Orillaza H
AD  - Department of Dermatology, University Hospitals Cleveland Medical Center, Case 
      Western Reserve University, Cleveland, Ohio.
FAU - Silver, Eli
AU  - Silver E
AD  - Division of Allergy and Immunology, University Hospitals Cleveland, Cleveland, 
      Ohio.
FAU - Rowland, Douglas Y
AU  - Rowland DY
AD  - Department of Population and Quantitative Health Sciences (PQHS), Case Western 
      Reserve University School of Medicine, Cleveland, Ohio.
FAU - Nedorost, Susan T
AU  - Nedorost ST
AUID- ORCID: 0000-0003-4355-4532
AD  - Department of Dermatology, University Hospitals Cleveland Medical Center, Case 
      Western Reserve University, Cleveland, Ohio.
AD  - Department of Population and Quantitative Health Sciences (PQHS), Case Western 
      Reserve University School of Medicine, Cleveland, Ohio.
LA  - eng
PT  - Journal Article
DEP - 20191211
PL  - England
TA  - Immun Inflamm Dis
JT  - Immunity, inflammation and disease
JID - 101635460
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens
MH  - Animals
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Dermatitis, Atopic/*diagnosis
MH  - Dermatitis, Contact/*diagnosis
MH  - Female
MH  - Food Hypersensitivity/immunology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Patch Tests/*methods
MH  - Pyroglyphidae/immunology
PMC - PMC7016841
OTO - NOTNLM
OT  - atopic dermatitis
OT  - atopy patch tests
OT  - elimination diets
OT  - protein contact dermatitis
OT  - systemic contact dermatitis
COIS- The authors declare that there are no conflict of interests.
EDAT- 2019/12/12 06:00
MHDA- 2020/12/15 06:00
PMCR- 2019/12/11
CRDT- 2019/12/12 06:00
PHST- 2019/08/31 00:00 [received]
PHST- 2019/10/14 00:00 [revised]
PHST- 2019/11/20 00:00 [accepted]
PHST- 2019/12/12 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2019/12/12 06:00 [entrez]
PHST- 2019/12/11 00:00 [pmc-release]
AID - IID3280 [pii]
AID - 10.1002/iid3.280 [doi]
PST - ppublish
SO  - Immun Inflamm Dis. 2020 Mar;8(1):24-29. doi: 10.1002/iid3.280. Epub 2019 Dec 11.