PMID- 31824267
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 13
DP  - 2019
TI  - Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic Target.
PG  - 519
LID - 10.3389/fncel.2019.00519 [doi]
LID - 519
AB  - Pericytes are functional components of the neurovascular unit (NVU) that are 
      located around the blood vessels, and their roles in the regulation of cerebral 
      health and diseases has been reported. Currently, the potential properties of 
      pericytes as emerging therapeutic targets for cerebrovascular diseases have 
      attracted considerable attention. Nonetheless, few reviews have comprehensively 
      discussed pericytes and their roles in cerebrovascular diseases. Therefore, in 
      this review, we not only summarized and described the basic characteristics of 
      pericytes but also focused on clarifying the new understanding about the roles of 
      pericytes in the pathogenesis of cerebrovascular diseases, including white matter 
      injury (WMI), hypoxic-ischemic brain damage, depression, neovascular 
      insufficiency disease, and Alzheimer's disease (AD). Furthermore, we summarized 
      the current therapeutic strategies targeting pericytes for cerebrovascular 
      diseases. Collectively, this review is aimed at providing a comprehensive 
      understanding of pericytes and new insights about the use of pericytes as novel 
      therapeutic targets for cerebrovascular diseases.
CI  - Copyright (c) 2019 Su, Huang, Qu, Xiao and Mu.
FAU - Su, Xiaojuan
AU  - Su X
AD  - Department of Paediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu, China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children, 
      Sichuan University, Ministry of Education, Chengdu, China.
FAU - Huang, Lingyi
AU  - Huang L
AD  - West China College of Stomatology, Sichuan University, Chengdu, China.
FAU - Qu, Yi
AU  - Qu Y
AD  - Department of Paediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu, China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children, 
      Sichuan University, Ministry of Education, Chengdu, China.
FAU - Xiao, Dongqiong
AU  - Xiao D
AD  - Department of Paediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu, China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children, 
      Sichuan University, Ministry of Education, Chengdu, China.
FAU - Mu, Dezhi
AU  - Mu D
AD  - Department of Paediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu, China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children, 
      Sichuan University, Ministry of Education, Chengdu, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191122
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC6882740
OTO - NOTNLM
OT  - angiogenesis
OT  - basement membrane
OT  - blood brain barrier
OT  - cerebrovascular disease
OT  - pericytes
EDAT- 2019/12/12 06:00
MHDA- 2019/12/12 06:01
PMCR- 2019/01/01
CRDT- 2019/12/12 06:00
PHST- 2019/05/13 00:00 [received]
PHST- 2019/11/05 00:00 [accepted]
PHST- 2019/12/12 06:00 [entrez]
PHST- 2019/12/12 06:00 [pubmed]
PHST- 2019/12/12 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2019.00519 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2019 Nov 22;13:519. doi: 10.3389/fncel.2019.00519. 
      eCollection 2019.