PMID- 31824450
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 10
DP  - 2019
TI  - Dengue Virus Infection Activates Interleukin-1beta to Induce Tissue Injury and 
      Vascular Leakage.
PG  - 2637
LID - 10.3389/fmicb.2019.02637 [doi]
LID - 2637
AB  - Dengue virus (DENV) infection causes several diseases ranging from dengue fever 
      to life-threatening dengue hemorrhagic fever and dengue shock syndrome 
      characterized by endothelial dysfunction, vascular leakage, and shock. Here, we 
      identify a potential mechanism by which DENV induces tissue injury and vascular 
      leakage by promoting the activation of interleukin (IL)-1beta. DENV facilitates 
      IL-1beta secretion in infected patients, mice, human peripheral blood mononuclear 
      cells (PBMCs), mouse bone marrow-derived macrophages (BMDMs), and 
      monocyte-differentiated macrophages (THP-1) via activating the NLRP3 
      inflammasome. The accumulated data suggest that IL-1beta probably induces vascular 
      leakage and tissue injury in interferon-alpha/beta receptor 1 deficient C57BL/6 
      mice (IFNAR (-/-) C57BL/6), whereas IL-1 receptor antagonist (IL-1RA) alleviates 
      these effects of IL-1beta. Finally, administration of recombinant IL-1beta protein 
      results in vascular leakage and tissue injury in C57BL/6 mice. Together, the 
      accumulated results demonstrate that IL-1beta contributes to DENV-associated 
      pathology and suggest that IL-1RA acts as a potential agent for the treatment of 
      DENV-associated diseases.
CI  - Copyright (c) 2019 Pan, Zhang, Liu, Wang, Yu, Lao, Zhang, Shen, Wan, Xiao, Shereen, 
      Zhang, Tan, Liu, Liu, Wu, Liu, Li and Wu.
FAU - Pan, Pan
AU  - Pan P
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan, China.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan, China.
FAU - Liu, Weiyong
AU  - Liu W
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan, China.
FAU - Wang, Wenbiao
AU  - Wang W
AD  - Key Laboratory of Virology of Guangzhou, Institute of Medical Microbiology, Jinan 
      University, Guangzhou, China.
FAU - Yu, Zhenyang
AU  - Yu Z
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan, China.
FAU - Lao, Zizhao
AU  - Lao Z
AD  - Center for Animal Experiment, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Center for Animal Experiment, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Shen, Miaomiao
AU  - Shen M
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan, China.
FAU - Wan, Pin
AU  - Wan P
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan, China.
FAU - Xiao, Feng
AU  - Xiao F
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan, China.
FAU - Shereen, Muhammad Adnan
AU  - Shereen MA
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan, China.
FAU - Zhang, Wen
AU  - Zhang W
AD  - Guangdong LongFan Biological Science and Technology, Foshan, China.
FAU - Tan, Qiuping
AU  - Tan Q
AD  - Guangdong LongFan Biological Science and Technology, Foshan, China.
FAU - Liu, Yuntao
AU  - Liu Y
AD  - Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China.
FAU - Liu, Xiaohong
AU  - Liu X
AD  - Center for Animal Experiment, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Wu, Kailang
AU  - Wu K
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan, China.
FAU - Liu, Yingle
AU  - Liu Y
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan, China.
AD  - Key Laboratory of Virology of Guangzhou, Institute of Medical Microbiology, Jinan 
      University, Guangzhou, China.
FAU - Li, Geng
AU  - Li G
AD  - Center for Animal Experiment, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Wu, Jianguo
AU  - Wu J
AD  - State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 
      Wuhan, China.
AD  - Key Laboratory of Virology of Guangzhou, Institute of Medical Microbiology, Jinan 
      University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20191122
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC6883832
OTO - NOTNLM
OT  - IL-1RA
OT  - IL-1beta
OT  - NLRP3 inflammasome
OT  - dengue virus
OT  - inflammatory response
OT  - vascular leakage
EDAT- 2019/12/12 06:00
MHDA- 2019/12/12 06:01
PMCR- 2019/11/22
CRDT- 2019/12/12 06:00
PHST- 2019/06/27 00:00 [received]
PHST- 2019/10/30 00:00 [accepted]
PHST- 2019/12/12 06:00 [entrez]
PHST- 2019/12/12 06:00 [pubmed]
PHST- 2019/12/12 06:01 [medline]
PHST- 2019/11/22 00:00 [pmc-release]
AID - 10.3389/fmicb.2019.02637 [doi]
PST - epublish
SO  - Front Microbiol. 2019 Nov 22;10:2637. doi: 10.3389/fmicb.2019.02637. eCollection 
      2019.