PMID- 31825801
OWN - NLM
STAT- MEDLINE
DCOM- 20201005
LR  - 20201005
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 143
DP  - 2020 Jan 15
TI  - Cellulose-based polymeric emulsifier stabilized poly(N-vinylcaprolactam) hydrogel 
      with temperature and pH responsiveness.
PG  - 190-199
LID - S0141-8130(19)37604-4 [pii]
LID - 10.1016/j.ijbiomac.2019.12.019 [doi]
AB  - N-vinylcaprolactam (NVCL) is a temperature-responsive monomer, which is widely 
      used for preparing responsive hydrogels. However, poor water solubility of NVCL 
      necessitates the use of emulsifiers for better dispersion. Hydrolyzed epoxy 
      soybean oil-grafted hydroxyethyl cellulose (H-ESO-HEC) polymeric emulsifier has 
      excellent emulsifying properties, and the carboxyl groups afford 
      pH-responsiveness to the hydrogels. A novel temperature- and pH-responsive 
      cellulose-based hydrogel was prepared by combining NVCL and H-ESO-HEC. The 
      hydrogel morphology, thermal stability, and swelling capacity were characterized, 
      and it was also used as a dual-responsive drug preservative carrier. Scanning 
      electron microscopy and thermogravimetric analysis confirmed the porous structure 
      and good thermal stability, respectively, of the hydrogel. The hydrogel displayed 
      a temperature- and pH-dependent swelling behavior and improved swelling capacity. 
      The swelling behavior agreed well with the Korsmeyer-Peppas model and Schott's 
      second-order kinetic model. The dual-responsive hydrogel has significant 
      potential in the drug delivery systems owing to its biocompatibility and 
      temperature and pH sensitivity.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Yang, Xinxin
AU  - Yang X
AD  - Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, 
      Key Laboratory of Biomass Energy and Material, Co-Innovation Center of Efficient 
      Processing and Utilization of Forest Resources, Key Lab. of Chemical Engineering 
      of Forest Products, National Forestry and Grassland Administration, National 
      Engineering Laboratory for Biomass Chemical Utilization, Nanjing 210042, Jiangsu 
      Province, China; College of Chemical Engineering, Advanced Analysis and Testing 
      Center, Nanjing Forestry University, Jiangsu Provincial Key Lab for the Chemistry 
      and Utilization of Agro-Forest Biomass, Nanjing 210037, Jiangsu Province, China.
FAU - Li, Zhaoshuang
AU  - Li Z
AD  - Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, 
      Key Laboratory of Biomass Energy and Material, Co-Innovation Center of Efficient 
      Processing and Utilization of Forest Resources, Key Lab. of Chemical Engineering 
      of Forest Products, National Forestry and Grassland Administration, National 
      Engineering Laboratory for Biomass Chemical Utilization, Nanjing 210042, Jiangsu 
      Province, China.
FAU - Liu, He
AU  - Liu H
AD  - Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, 
      Key Laboratory of Biomass Energy and Material, Co-Innovation Center of Efficient 
      Processing and Utilization of Forest Resources, Key Lab. of Chemical Engineering 
      of Forest Products, National Forestry and Grassland Administration, National 
      Engineering Laboratory for Biomass Chemical Utilization, Nanjing 210042, Jiangsu 
      Province, China. Electronic address: liuhe.caf@gmail.com.
FAU - Ma, Lina
AU  - Ma L
AD  - State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of 
      Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.. 
      Electronic address: malina@ciac.ac.cn.
FAU - Huang, Xujuan
AU  - Huang X
AD  - School of Chemical and Chemistry, Yancheng Institute of Technology, Yancheng 
      221051, Jiangsu Province, China.
FAU - Cai, Zhaosheng
AU  - Cai Z
AD  - School of Chemical and Chemistry, Yancheng Institute of Technology, Yancheng 
      221051, Jiangsu Province, China.
FAU - Xu, Xu
AU  - Xu X
AD  - College of Chemical Engineering, Advanced Analysis and Testing Center, Nanjing 
      Forestry University, Jiangsu Provincial Key Lab for the Chemistry and Utilization 
      of Agro-Forest Biomass, Nanjing 210037, Jiangsu Province, China. Electronic 
      address: xuxu200121@hotmail.com.
FAU - Shang, Shibin
AU  - Shang S
AD  - Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, 
      Key Laboratory of Biomass Energy and Material, Co-Innovation Center of Efficient 
      Processing and Utilization of Forest Resources, Key Lab. of Chemical Engineering 
      of Forest Products, National Forestry and Grassland Administration, National 
      Engineering Laboratory for Biomass Chemical Utilization, Nanjing 210042, Jiangsu 
      Province, China.
FAU - Song, Zhanqian
AU  - Song Z
AD  - Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, 
      Key Laboratory of Biomass Energy and Material, Co-Innovation Center of Efficient 
      Processing and Utilization of Forest Resources, Key Lab. of Chemical Engineering 
      of Forest Products, National Forestry and Grassland Administration, National 
      Engineering Laboratory for Biomass Chemical Utilization, Nanjing 210042, Jiangsu 
      Province, China.
LA  - eng
PT  - Journal Article
DEP - 20191209
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Drug Carriers)
RN  - 0 (Emulsifying Agents)
RN  - 0 (Emulsions)
RN  - 0 (Hydrogels)
RN  - 0 (Polymers)
RN  - 25189-83-7 (poly-N-vinylcaprolactam)
RN  - 6879X594Z8 (Caprolactam)
RN  - 9004-34-6 (Cellulose)
SB  - IM
MH  - Caprolactam/*analogs & derivatives/chemistry
MH  - Cellulose/*chemistry
MH  - Drug Carriers/chemistry
MH  - Drug Delivery Systems
MH  - Drug Liberation
MH  - Emulsifying Agents/*chemistry
MH  - Emulsions
MH  - Hydrogels/*chemistry
MH  - *Hydrogen-Ion Concentration
MH  - Polymers/*chemistry
MH  - Spectrum Analysis
MH  - *Temperature
MH  - Thermodynamics
OTO - NOTNLM
OT  - Cellulose-based emulsifier
OT  - Drug release
OT  - Responsiveness
EDAT- 2019/12/12 06:00
MHDA- 2020/10/06 06:00
CRDT- 2019/12/12 06:00
PHST- 2019/09/19 00:00 [received]
PHST- 2019/11/19 00:00 [revised]
PHST- 2019/12/02 00:00 [accepted]
PHST- 2019/12/12 06:00 [pubmed]
PHST- 2020/10/06 06:00 [medline]
PHST- 2019/12/12 06:00 [entrez]
AID - S0141-8130(19)37604-4 [pii]
AID - 10.1016/j.ijbiomac.2019.12.019 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2020 Jan 15;143:190-199. doi: 
      10.1016/j.ijbiomac.2019.12.019. Epub 2019 Dec 9.