PMID- 31825940
OWN - NLM
STAT- MEDLINE
DCOM- 20200622
LR  - 20200622
IS  - 1421-9913 (Electronic)
IS  - 0014-3022 (Linking)
VI  - 82
IP  - 4-6
DP  - 2019
TI  - Hypertension with Hyperhomocysteinemia Increases the Risk of Early Cognitive 
      Impairment after First-Ever Ischemic Stroke.
PG  - 75-85
LID - 10.1159/000504704 [doi]
AB  - BACKGROUND: Hypertension and hyperhomocysteinemia (HHcy) are independent risk 
      factors of stroke and are associated with each other. Although evidence suggests 
      that they are related to cognitive impairment, the relationship between 
      hypertension accompanied with HHcy and poststroke cognitive impairment (PSCI) is 
      unclear. OBJECTIVE: To define the relationship between hypertension with HHcy and 
      early cognitive impairment after acute cerebral infarction. MATERIALS AND 
      METHODS: Our study enrolled 232 patients with acute first-ever ischemic stroke. 
      Patients were assigned to 3 groups by blood pressure and homocysteine (Hcy) 
      levels: hypertension with HHcy, simple hypertension, or control. Cognition was 
      assessed by the Montreal cognitive assessment at admission and at 3- and 6-month 
      follow-ups. RESULTS: The hypertension with HHcy group exhibited the highest 
      incidence of early cognitive impairment (simple hypertension: p = 0.000; control: 
      p = 0.000). This group also had lower visual space/executive scores than the 
      simple hypertension group (p = 0.000) and lower delayed recall scores than the 
      control group (p = 0.011). Multivariate analysis showed that hypertension with 
      HHcy (OR 7.797; 95% CI 2.917-20.843; p = 0.000), the level of serum Hcy (OR 
      1.063; 95% CI 1.109-1.109; p = 0.005), education years (OR 0.797; 95% CI 
      0.722-0.880; p = 0.000), and Fazekas scale of leukoaraiosis (OR 1.648; 95% CI 
      1.239-2.191; p = 0.001) were independent influencing factors of early PSCI; 
      however, simple hypertension (OR 1.183, 95% CI 0.208-6.737; p = 0.850) and simple 
      HHcy (OR 1.112, 95% CI 0.181-6.810; p = 0.909) were not. CONCLUSION: Patients 
      with both hypertension and HHcy are at an increased risk of early cognitive 
      impairment after acute first-ever ischemic stroke.
CI  - (c) 2019 S. Karger AG, Basel.
FAU - Lu, Zhen-Hui
AU  - Lu ZH
AD  - Department of Neurology, Second Affiliated Hospital of Soochow University, 
      Suzhou, China.
AD  - Department of Neurology, Second Affiliated Hospital of Nantong University, 
      Nantong, China.
FAU - Li, Jia
AU  - Li J
AD  - Department of Neurology, Second Affiliated Hospital of Nantong University, 
      Nantong, China.
FAU - Li, Xin-Ling
AU  - Li XL
AD  - Department of Neurology, Second Affiliated Hospital of Nantong University, 
      Nantong, China.
FAU - Ding, Mei
AU  - Ding M
AD  - Department of Neurology, Second Affiliated Hospital of Nantong University, 
      Nantong, China.
FAU - Mao, Cheng-Jie
AU  - Mao CJ
AD  - Department of Neurology, Second Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Zhu, Xiang-Yang
AU  - Zhu XY
AD  - Department of Neurology, Second Affiliated Hospital of Nantong University, 
      Nantong, China.
FAU - Liu, Chun-Feng
AU  - Liu CF
AD  - Department of Neurology, Second Affiliated Hospital of Soochow University, 
      Suzhou, China, liuchunfeng@suda.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191211
PL  - Switzerland
TA  - Eur Neurol
JT  - European neurology
JID - 0150760
SB  - IM
MH  - Aged
MH  - Brain Ischemia/complications
MH  - Cognitive Dysfunction/epidemiology/*etiology
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Hypertension/*complications
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Risk Factors
MH  - Stroke/*complications
OTO - NOTNLM
OT  - Cognitive impairment
OT  - Hyperhomocysteinemia
OT  - Hypertension
OT  - Ischemic stroke
EDAT- 2019/12/12 06:00
MHDA- 2020/06/23 06:00
CRDT- 2019/12/12 06:00
PHST- 2019/08/11 00:00 [received]
PHST- 2019/11/10 00:00 [accepted]
PHST- 2019/12/12 06:00 [pubmed]
PHST- 2020/06/23 06:00 [medline]
PHST- 2019/12/12 06:00 [entrez]
AID - 000504704 [pii]
AID - 10.1159/000504704 [doi]
PST - ppublish
SO  - Eur Neurol. 2019;82(4-6):75-85. doi: 10.1159/000504704. Epub 2019 Dec 11.