PMID- 31826386
OWN - NLM
STAT- MEDLINE
DCOM- 20200515
LR  - 20200515
IS  - 1440-6047 (Electronic)
IS  - 0964-7058 (Linking)
VI  - 28
IP  - 4
DP  - 2019
TI  - Genetic and epigenetic regulation of BHMT is associated with folate therapy 
      efficacy in hyperhomocysteinaemia.
PG  - 879-887
LID - 10.6133/apjcn.201912_28(4).0025 [doi]
AB  - BACKGROUND AND OBJECTIVES: Hyperhomocysteinaemia (HHcy) is an independent risk 
      factors for several disorders, including cardiovascular disease. The 
      understanding of the relationship among genetic, epigenetic and the efficacy of 
      folate therapy for HHcy remain unclear. This study aim to investigate whether 
      betaine-homocysteine methyltransferase (BHMT) single-nucleotide polymorphisms 
      (SNPs) and DNA methylation are related to the efficacy of folate therapy for HHcy 
      and whether BHMT DNA methylation mediates the SNP-folate therapy efficacy 
      association. METHODS AND STUDY DESIGN: A total of 638 patients with HHcy were 
      involved in this prospective cohort study. Logistic and linear regression was 
      used to explore associations among SNPs, DNA methylation, and folate therapy 
      efficacy. Finally, mediation analysis was performed to investigate whether DNA 
      methylation of BHMT mediates the association between SNPs and folate therapy 
      efficacy. RESULTS: BHMT rs3733890 was significantly associated with folate 
      therapy efficacy (p<0.05). BHMT and BHMT_1 DNA methylation level was 
      significantly associated with folate therapy efficacy (p=0.017 and p=0.028). DNA 
      methylation of BHMT and BHMT_1 mediated 34.84% and 33.06% of the effect of 
      rs3733890 on folate therapy efficacy, respectively. CONCLUSIONS: There has a 
      consistent interrelationship among BHMT genetic variants, methylation levels of 
      BHMT, and folate therapy efficacy. BHMT and BHMT_1 DNA methylation proportionally 
      mediated the effects of rs3733890 SNPs on the efficacy of folate therapy for 
      HHcy.
FAU - Li, Dankang
AU  - Li D
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, Henan, 
      China.
FAU - Yang, Jiao
AU  - Yang J
AD  - Department of Nutrition and Food Hygiene School of Public health, Peking 
      University, Beijing, China.
FAU - Zhao, Qinglin
AU  - Zhao Q
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, Henan, 
      China.
FAU - Zhang, Chengda
AU  - Zhang C
AD  - Department of International Medicine, Beaumont Health System, MI, United States 
      of America.
FAU - Ren, Bingnan
AU  - Ren B
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, Henan, 
      China.
FAU - Yue, Limin
AU  - Yue L
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, Henan, 
      China.
FAU - Du, Binghui
AU  - Du B
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, Henan, 
      China.
FAU - Godfrey, Opolot
AU  - Godfrey O
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, Henan, 
      China.
FAU - Huang, Xiaowen
AU  - Huang X
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, Henan, 
      China.
FAU - Zhang, Weidong
AU  - Zhang W
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, Henan, 
      China. imooni@163.com.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Asia Pac J Clin Nutr
JT  - Asia Pacific journal of clinical nutrition
JID - 9440304
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 2.1.1.5 (BHMT protein, human)
RN  - EC 2.1.1.5 (Betaine-Homocysteine S-Methyltransferase)
SB  - IM
MH  - Aged
MH  - Betaine-Homocysteine S-Methyltransferase/genetics/*metabolism
MH  - Cohort Studies
MH  - *Epigenesis, Genetic
MH  - Female
MH  - Folic Acid/*therapeutic use
MH  - Gene Expression Regulation/*drug effects/physiology
MH  - Genotype
MH  - Humans
MH  - Hyperhomocysteinemia/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
EDAT- 2019/12/12 06:00
MHDA- 2020/05/16 06:00
CRDT- 2019/12/12 06:00
PHST- 2019/12/12 06:00 [entrez]
PHST- 2019/12/12 06:00 [pubmed]
PHST- 2020/05/16 06:00 [medline]
AID - 10.6133/apjcn.201912_28(4).0025 [doi]
PST - ppublish
SO  - Asia Pac J Clin Nutr. 2019;28(4):879-887. doi: 10.6133/apjcn.201912_28(4).0025.