PMID- 31827375
OWN - NLM
STAT- MEDLINE
DCOM- 20200601
LR  - 20220411
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2019
DP  - 2019
TI  - Dance Training Improves Cytokine Secretion and Viability of Neutrophils in 
      Diabetic Patients.
PG  - 2924818
LID - 10.1155/2019/2924818 [doi]
LID - 2924818
AB  - BACKGROUND: Evidence suggests that exercise improves neutrophil function. The 
      decreased functional longevity of neutrophils and their increased clearance from 
      infectious sites contribute to the increased susceptibility to infection and 
      severity of infection observed in patients with diabetes. OBJECTIVE: Herein, we 
      investigated the effects of a dance program on neutrophil number, function, and 
      death in type 2 diabetes mellitus (T2DM) patients and healthy volunteers. 
      METHODS: Ten patients with T2DM and twelve healthy individuals participated in a 
      moderate-intensity dance training program for 4 months. The plasma levels of 
      leptin, free fatty acids (FFAs), tumour necrosis factor-alpha (TNF-alpha), C-reactive 
      protein (CRP), interleukin-1beta (IL-1beta), and interleukin-1 receptor antagonist 
      (IL-1ra); neutrophil counts; extent of DNA fragmentation; cell membrane 
      integrity; and production of TNF-alpha, interleukin-8 (IL-8), interleukin-6 (IL-6), 
      and IL-1beta in neutrophils were measured before and after training. RESULTS: 
      Training reduced plasma levels of TNF-alpha (1.9-fold in controls and 2.2-fold in 
      patients with T2DM) and CRP (1.4-fold in controls and 3.4-fold in patients with 
      T2DM). IL-1ra levels were higher in the control group (2.2-fold) after training. 
      After training, neutrophil DNA fragmentation was decreased in patients with T2DM 
      (90%), while the number of neutrophils increased (70% in controls and 1.1-fold in 
      patients with T2DM). CONCLUSION: Dance training is a nonpharmacological strategy 
      to reduce inflammation and improve neutrophil clearance in patients with T2DM.
CI  - Copyright (c) 2019 Leandro Borges et al.
FAU - Borges, Leandro
AU  - Borges L
AUID- ORCID: 0000-0002-9755-2535
AD  - Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, 
      Sao Paulo 01506-000, Brazil.
FAU - Passos, Maria E P
AU  - Passos MEP
AD  - Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, 
      Sao Paulo 01506-000, Brazil.
FAU - Silva, Maysa B B
AU  - Silva MBB
AD  - Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, 
      Sao Paulo 01506-000, Brazil.
FAU - Santos, Vinicius C
AU  - Santos VC
AD  - Sao Paulo University (USP), Sao Paulo 05508-900, Brazil.
FAU - Momesso, Cesar M
AU  - Momesso CM
AUID- ORCID: 0000-0001-6448-6028
AD  - Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, 
      Sao Paulo 01506-000, Brazil.
FAU - Pithon-Curi, Tania C
AU  - Pithon-Curi TC
AD  - Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, 
      Sao Paulo 01506-000, Brazil.
FAU - Gorjao, Renata
AU  - Gorjao R
AD  - Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, 
      Sao Paulo 01506-000, Brazil.
FAU - Gray, Stuart R
AU  - Gray SR
AUID- ORCID: 0000-0002-9543-7437
AD  - Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow 
      G12 8TA, UK.
FAU - Lima, Kaue C A
AU  - Lima KCA
AD  - Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, 
      Sao Paulo 01506-000, Brazil.
FAU - de Freitas, Paulo B
AU  - de Freitas PB
AUID- ORCID: 0000-0002-0406-041X
AD  - Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, 
      Sao Paulo 01506-000, Brazil.
AD  - Department of Neurology, Milton S. Hershey Medical Center, The Pennsylvania State 
      University, Hershey, PA 16801, USA.
AD  - Department of Kinesiology, The Pennsylvania State University, University Park, PA 
      16802, USA.
FAU - Hatanaka, Elaine
AU  - Hatanaka E
AUID- ORCID: 0000-0002-9716-1163
AD  - Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, 
      Sao Paulo 01506-000, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20191120
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Dancing/*physiology
MH  - Diabetes Mellitus, Type 2/*metabolism/*therapy
MH  - Female
MH  - Humans
MH  - Interleukin-1beta/metabolism
MH  - Interleukin-6/metabolism
MH  - Interleukin-8/metabolism
MH  - Middle Aged
MH  - Neutrophils/cytology/*metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
PMC - PMC6886327
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2019/12/13 06:00
MHDA- 2020/06/02 06:00
PMCR- 2019/11/20
CRDT- 2019/12/13 06:00
PHST- 2019/07/22 00:00 [received]
PHST- 2019/10/14 00:00 [revised]
PHST- 2019/10/24 00:00 [accepted]
PHST- 2019/12/13 06:00 [entrez]
PHST- 2019/12/13 06:00 [pubmed]
PHST- 2020/06/02 06:00 [medline]
PHST- 2019/11/20 00:00 [pmc-release]
AID - 10.1155/2019/2924818 [doi]
PST - epublish
SO  - Mediators Inflamm. 2019 Nov 20;2019:2924818. doi: 10.1155/2019/2924818. 
      eCollection 2019.