PMID- 31827641
OWN - NLM
STAT- MEDLINE
DCOM- 20200501
LR  - 20220411
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2019
DP  - 2019
TI  - Association between MIC-1 and Type 2 Diabetes: A Combined Analysis.
PG  - 7284691
LID - 10.1155/2019/7284691 [doi]
LID - 7284691
AB  - BACKGROUND AND OBJECTIVES: Type 2 diabetes mellitus (T2DM) is an epidemic disease 
      that endangers human health seriously. Recently, a large number of reports have 
      revealed that macrophage-inhibiting cytokine-1 (MIC-1) is linked with T2DM, but 
      the results were inconclusive. The aim of this study was to perform 
      bioinformatics analysis of the association between MIC-1 and T2DM. MATERIAL AND 
      METHODS: Datasets and relevant literatures were searched in Gene Expression 
      Omnibus (GEO), PubMed, Google Scholar, and Web of Science till September 20, 
      2019. Expression levels of MIC-1 were extracted, pooled, and compared between 
      T2DM cases and controls. RESULTS: In summary, 11 GEO datasets and 3 articles with 
      421 T2DM cases and 711 controls were finally included. The expression level of 
      MIC-1 was significantly higher in T2DM patients compared with controls, with a 
      standard mean difference (SMD) of 0.54 and a 95% confidence interval (95% CI) of 
      0.24-0.83; in blood samples, the difference was still significant (SMD = 0.65; 
      95%CI = 0.24-1.06). Meanwhile, the expression level of MIC-1 plays a significant 
      role in differentiating T2DM cases from controls; the combined sensitivity, 
      specificity, and odds ratio were 0.83 (95%CI = 0.72-0.90), 0.59 (95%CI = 
      0.45-0.72), and 1.64 (95%CI = 1.35-1.99), respectively. The summary receiver 
      operating characteristic (SROC) curve demonstrated that the area under the curve 
      (AUC) was 0.81 (95%CI = 0.77-0.84). CONCLUSION: Our results suggested that the 
      expression levels of MIC-1 were significantly higher in T2DM patients in multiple 
      tissues including blood samples.
CI  - Copyright (c) 2019 Jianan Lu et al.
FAU - Lu, Jianan
AU  - Lu J
AUID- ORCID: 0000-0002-9630-1793
AD  - Department of Epidemiology and Biostatics, Jiangsu Key Laboratory of Preventive 
      and Translational Medicine for Geriatric Diseases, School of Public Health, 
      Medical College of Soochow University, 199 Ren Ai Road, Suzhou, China.
FAU - Zhang, Yue
AU  - Zhang Y
AUID- ORCID: 0000-0001-6682-0093
AD  - Department of Epidemiology and Biostatics, Jiangsu Key Laboratory of Preventive 
      and Translational Medicine for Geriatric Diseases, School of Public Health, 
      Medical College of Soochow University, 199 Ren Ai Road, Suzhou, China.
FAU - Dong, Xingxuan
AU  - Dong X
AUID- ORCID: 0000-0001-6791-4833
AD  - Department of Epidemiology and Biostatics, Jiangsu Key Laboratory of Preventive 
      and Translational Medicine for Geriatric Diseases, School of Public Health, 
      Medical College of Soochow University, 199 Ren Ai Road, Suzhou, China.
FAU - Lu, Jiawen
AU  - Lu J
AUID- ORCID: 0000-0003-2671-3028
AD  - Department of Epidemiology and Biostatics, Jiangsu Key Laboratory of Preventive 
      and Translational Medicine for Geriatric Diseases, School of Public Health, 
      Medical College of Soochow University, 199 Ren Ai Road, Suzhou, China.
FAU - Zhang, Chen
AU  - Zhang C
AUID- ORCID: 0000-0002-8385-0961
AD  - Department of Epidemiology and Biostatics, Jiangsu Key Laboratory of Preventive 
      and Translational Medicine for Geriatric Diseases, School of Public Health, 
      Medical College of Soochow University, 199 Ren Ai Road, Suzhou, China.
FAU - Liu, Jieyu
AU  - Liu J
AUID- ORCID: 0000-0002-3315-8598
AD  - Department of Epidemiology and Biostatics, Jiangsu Key Laboratory of Preventive 
      and Translational Medicine for Geriatric Diseases, School of Public Health, 
      Medical College of Soochow University, 199 Ren Ai Road, Suzhou, China.
FAU - Yu, Qingzhou
AU  - Yu Q
AUID- ORCID: 0000-0002-0762-2094
AD  - Department of Epidemiology and Biostatics, Jiangsu Key Laboratory of Preventive 
      and Translational Medicine for Geriatric Diseases, School of Public Health, 
      Medical College of Soochow University, 199 Ren Ai Road, Suzhou, China.
FAU - Teng, Haoyue
AU  - Teng H
AUID- ORCID: 0000-0001-6457-6824
AD  - Department of Epidemiology and Biostatics, Jiangsu Key Laboratory of Preventive 
      and Translational Medicine for Geriatric Diseases, School of Public Health, 
      Medical College of Soochow University, 199 Ren Ai Road, Suzhou, China.
FAU - Yao, Qingkui
AU  - Yao Q
AUID- ORCID: 0000-0001-9750-7999
AD  - Community Health Service Center of Minglou, Subdistrict Jiangdong District, 
      Ningbo, China.
FAU - Yin, Jieyun
AU  - Yin J
AUID- ORCID: 0000-0002-5265-3930
AD  - Department of Epidemiology and Biostatics, Jiangsu Key Laboratory of Preventive 
      and Translational Medicine for Geriatric Diseases, School of Public Health, 
      Medical College of Soochow University, 199 Ren Ai Road, Suzhou, China.
FAU - Qin, Liqiang
AU  - Qin L
AUID- ORCID: 0000-0002-5231-2562
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Soochow 
      University, Suzhou, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20191116
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (GDF15 protein, human)
RN  - 0 (Growth Differentiation Factor 15)
SB  - IM
MH  - Diabetes Mellitus, Type 2/metabolism/*pathology
MH  - Growth Differentiation Factor 15/*metabolism
MH  - Humans
MH  - Prognosis
PMC - PMC6885201
COIS- No potential conflict of interest was reported by the authors.
EDAT- 2019/12/13 06:00
MHDA- 2020/05/02 06:00
PMCR- 2019/11/16
CRDT- 2019/12/13 06:00
PHST- 2019/04/19 00:00 [received]
PHST- 2019/09/23 00:00 [revised]
PHST- 2019/10/03 00:00 [accepted]
PHST- 2019/12/13 06:00 [entrez]
PHST- 2019/12/13 06:00 [pubmed]
PHST- 2020/05/02 06:00 [medline]
PHST- 2019/11/16 00:00 [pmc-release]
AID - 10.1155/2019/7284691 [doi]
PST - epublish
SO  - Dis Markers. 2019 Nov 16;2019:7284691. doi: 10.1155/2019/7284691. eCollection 
      2019.