PMID- 31827909
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2019
DP  - 2019
TI  - Association between Hyperreflective Foci on Spectral-Domain Optical Coherence 
      Tomography and Early Recurrence of Diabetic Macular Edema after Intravitreal 
      Dexamethasone Implantation.
PG  - 3459164
LID - 10.1155/2019/3459164 [doi]
LID - 3459164
AB  - PURPOSE: To investigate the associations between hyperreflective foci (HRF) on 
      spectral-domain optical coherence tomography (SD-OCT) and early recurrence of 
      macular edema after intravitreal dexamethasone (DEX) implantation in eyes with 
      refractory diabetic macular edema (DME) to bevacizumab. METHODS: Medical records 
      of patients with refractory DME to bevacizumab, who underwent intravitreal DEX 
      implantation and 12-month follow-up, were reviewed. Eyes in which central 
      subfield thickness (CST) increased over 50 mum at 3 months compared with the first 
      month after intravitreal DEX implantation were categorized into the early 
      recurrence group, and the others were categorized into the late recurrence group. 
      Best-corrected visual acuity (BCVA), CST, and number of HRF on SD-OCT were 
      analyzed. RESULTS: Twenty-nine eyes of 26 patients (16 eyes in the early 
      recurrence group and 13 eyes in the late recurrence group) were included in this 
      study. The numbers of HRF in entire retina, inner retina, and outer retina at 
      baseline in the early recurrence group (11.38 +/- 3.07 in entire retina, 
      5.44 +/- 1.50 in inner retina, 5.94 +/- 2.74 in outer retina) were significantly 
      greater than those in the late recurrence group (7.54 +/- 3.60 in entire retina, 
      p=0.006; 4.08 +/- 1.70 in inner retina, p=0.034; 3.46 +/- 2.30 in outer retina, 
      p=0.013). Multivariate logistic regression analysis showed that a higher number 
      of HRF increased the risk of early recurrence after intravitreal DEX implantation 
      (odds ratio in entire retina: 1.518, p=0.012; odds ratio in inner retina: 2.058, 
      p=0.027; odds ratio in outer retina: 1.610, p=0.029). CONCLUSIONS: Higher 
      baseline numbers of HRF on SD-OCT may be a predictive indicator of early 
      recurrence of macular edema after intravitreal DEX implantation for DME.
CI  - Copyright (c) 2019 Kyung Tae Kim et al.
FAU - Kim, Kyung Tae
AU  - Kim KT
AUID- ORCID: 0000-0003-0495-930X
AD  - Department of Ophthalmology, Gangneung Asan Hospital, College of Medicine, 
      University of Ulsan, Ulsan, Republic of Korea.
FAU - Kim, Dong Yoon
AU  - Kim DY
AUID- ORCID: 0000-0002-6058-0145
AD  - Department of Ophthalmology, Chungbuk National University Hospital, College of 
      Medicine, Chungbuk National University, Cheongju, Republic of Korea.
FAU - Chae, Ju Byung
AU  - Chae JB
AUID- ORCID: 0000-0002-5233-0373
AD  - Department of Ophthalmology, Chungbuk National University Hospital, College of 
      Medicine, Chungbuk National University, Cheongju, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20191119
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC6885809
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2019/12/13 06:00
MHDA- 2019/12/13 06:01
PMCR- 2019/11/19
CRDT- 2019/12/13 06:00
PHST- 2019/05/20 00:00 [received]
PHST- 2019/10/12 00:00 [accepted]
PHST- 2019/12/13 06:00 [entrez]
PHST- 2019/12/13 06:00 [pubmed]
PHST- 2019/12/13 06:01 [medline]
PHST- 2019/11/19 00:00 [pmc-release]
AID - 10.1155/2019/3459164 [doi]
PST - epublish
SO  - J Ophthalmol. 2019 Nov 19;2019:3459164. doi: 10.1155/2019/3459164. eCollection 
      2019.