PMID- 31828124
OWN - NLM
STAT- MEDLINE
DCOM- 20200427
LR  - 20200427
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2019
DP  - 2019
TI  - Polydatin Inhibits Adipose Tissue Inflammation and Ameliorates Lipid Metabolism 
      in High-Fat-Fed Mice.
PG  - 7196535
LID - 10.1155/2019/7196535 [doi]
LID - 7196535
AB  - Polydatin (PD), an active component of Chinese herbs, is reported to have many 
      biological functions, such as cardioprotective actions, anti-inflammatory 
      activities, and antitumor effects. In this study, we investigated the effects of 
      PD on body weight control, glucose and lipid metabolic regulation, and 
      anti-inflammation in a high-fat-diet- (HFD-) induced obese mice model. After 
      treatment of PD (100 mg/kg/d for 4 weeks), HFD mice reduced body weight, 
      retroperitoneal fat mass, and adipose cell sizes; significantly lowered serum 
      total cholesterol triglyceride (TG) and low-density lipoprotein (LDL) levels; and 
      increased high-density lipoprotein (HDL) levels compared with the HFD control 
      mice. Further studies showed that PD downregulated the mRNA and protein 
      expressions of peroxisome proliferator-activated receptor gamma (PPARgamma), a 
      transcription factor involving in the regulation of adipocyte differentiation, in 
      the retroperitoneal fat of HFD mice. Additionally, PD significantly upregulated 
      the mRNA and protein expressions of leptin, an adipocyte-derived anorexic hormone 
      that regulates food intake and energy expenditure, in the adipose tissues of HFD 
      mice. Moreover, PD reduced the expression levels of monocyte chemoattractant 
      protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in the retroperitoneal 
      and epididymal tissues of HFD mice, suggesting that PD prevented adipose tissue 
      inflammation. In conclusion, PD may serve as a pharmaceutic candidate for 
      obesity-related lipid metabolism, anti-inflammation, and body weight loss.
CI  - Copyright (c) 2019 Li Zheng et al.
FAU - Zheng, Li
AU  - Zheng L
AUID- ORCID: 0000-0001-5360-4463
AD  - The Key Laboratory, The Second Affiliated Hospital of Jiaxing University, 
      Jiaxing, Zhejiang 314000, China.
FAU - Wu, Jiayuan
AU  - Wu J
AD  - The Key Laboratory, The Second Affiliated Hospital of Jiaxing University, 
      Jiaxing, Zhejiang 314000, China.
FAU - Mo, Juanfen
AU  - Mo J
AD  - The Key Laboratory, The Second Affiliated Hospital of Jiaxing University, 
      Jiaxing, Zhejiang 314000, China.
FAU - Guo, Li
AU  - Guo L
AD  - The Key Laboratory, The Second Affiliated Hospital of Jiaxing University, 
      Jiaxing, Zhejiang 314000, China.
FAU - Wu, Xiaoyan
AU  - Wu X
AD  - Clinical Laboratory, The Second Affiliated Hospital of Jiaxing University, 
      Jiaxing, Zhejiang 314000, China.
FAU - Bao, Yi
AU  - Bao Y
AUID- ORCID: 0000-0001-7144-5849
AD  - The Key Laboratory, The Second Affiliated Hospital of Jiaxing University, 
      Jiaxing, Zhejiang 314000, China.
LA  - eng
PT  - Journal Article
DEP - 20191115
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Glucosides)
RN  - 0 (PPAR gamma)
RN  - 0 (Stilbenes)
RN  - XM261C37CQ (polydatin)
SB  - IM
MH  - Adipose Tissue/*drug effects
MH  - Administration, Oral
MH  - Animals
MH  - *Diet, High-Fat
MH  - Energy Metabolism/drug effects
MH  - Glucosides/administration & dosage/*pharmacology
MH  - Inflammation/*metabolism
MH  - Lipid Metabolism/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Obese
MH  - PPAR gamma/metabolism
MH  - Stilbenes/administration & dosage/*pharmacology
PMC - PMC6885157
COIS- The authors declare that there are no conflicts of interest regarding the 
      publication of this article.
EDAT- 2019/12/13 06:00
MHDA- 2020/04/28 06:00
PMCR- 2019/11/15
CRDT- 2019/12/13 06:00
PHST- 2019/08/19 00:00 [received]
PHST- 2019/10/14 00:00 [revised]
PHST- 2019/10/18 00:00 [accepted]
PHST- 2019/12/13 06:00 [entrez]
PHST- 2019/12/13 06:00 [pubmed]
PHST- 2020/04/28 06:00 [medline]
PHST- 2019/11/15 00:00 [pmc-release]
AID - 10.1155/2019/7196535 [doi]
PST - epublish
SO  - Biomed Res Int. 2019 Nov 15;2019:7196535. doi: 10.1155/2019/7196535. eCollection 
      2019.