PMID- 31828143
OWN - NLM
STAT- MEDLINE
DCOM- 20200423
LR  - 20200423
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2019
DP  - 2019
TI  - HIF-1-miR-219-SMC4 Regulatory Pathway Promoting Proliferation and Migration of 
      HCC under Hypoxic Condition.
PG  - 8983704
LID - 10.1155/2019/8983704 [doi]
LID - 8983704
AB  - This paper aims to investigate the function of structural maintenance of 
      chromosome 4 (SMC4) in the progression of hepatocellular carcinoma (HCC) under 
      hypoxic condition. In this study, we found that suppression of SMC4 could inhibit 
      proliferation and migration of HCC cells through inducing G1 phase arrest and 
      affecting process of epithelial-mesenchymal transition (EMT) under hypoxic 
      condition. Moreover, we demonstrated that SMC4 was transcriptionally regulated by 
      hypoxia-inducible factor-1 (HIF-1) under hypoxic condition. As SMC has been shown 
      to be a target gene of miR-219, we observed that miR-219 was downregulated under 
      hypoxic condition and suppression of HIF-1a could lead to the upregulation of 
      miR-219. We also proved that miR-219 could affect the proliferation and migration 
      of HCC cells under hypoxic condition. In conclusion, our study demonstrated a 
      novel HIF-1-miR-219-SMC4 regulatory pathway under hypoxic condition in HCC cells.
CI  - Copyright (c) 2019 Yang Chen et al.
FAU - Chen, Yang
AU  - Chen Y
AD  - Department of General Surgery, The Seventh Hospital of Sun Yat-sen University, 
      Shenzhen, Guangdong Province 518107, China.
FAU - Huang, Fei
AU  - Huang F
AD  - Department of General Surgery, The Seventh Hospital of Sun Yat-sen University, 
      Shenzhen, Guangdong Province 518107, China.
FAU - Deng, Liang
AU  - Deng L
AD  - Department of General Surgery, The Seventh Hospital of Sun Yat-sen University, 
      Shenzhen, Guangdong Province 518107, China.
FAU - Yuan, Xiaowei
AU  - Yuan X
AD  - Department of General Surgery, The Seventh Hospital of Sun Yat-sen University, 
      Shenzhen, Guangdong Province 518107, China.
FAU - Tao, Qiang
AU  - Tao Q
AD  - Department of General Surgery, The Seventh Hospital of Sun Yat-sen University, 
      Shenzhen, Guangdong Province 518107, China.
FAU - Wang, Tielong
AU  - Wang T
AD  - Department of General Surgery, The Seventh Hospital of Sun Yat-sen University, 
      Shenzhen, Guangdong Province 518107, China.
FAU - Li, Dong
AU  - Li D
AD  - Department of General Surgery, The Seventh Hospital of Sun Yat-sen University, 
      Shenzhen, Guangdong Province 518107, China.
FAU - Fan, Youwen
AU  - Fan Y
AD  - Department of General Surgery, The Seventh Hospital of Sun Yat-sen University, 
      Shenzhen, Guangdong Province 518107, China.
FAU - Peng, Quanzhou
AU  - Peng Q
AD  - Department of Pathology, Shenzhen People's Hospital, Shenzhen, Guangdong Province 
      518107, China.
FAU - Tang, Di
AU  - Tang D
AUID- ORCID: 0000-0001-6851-9835
AD  - Department of General Surgery, The Seventh Hospital of Sun Yat-sen University, 
      Shenzhen, Guangdong Province 518107, China.
LA  - eng
PT  - Journal Article
DEP - 20191107
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Chromosomal Proteins, Non-Histone)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (MIRN219 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Neoplasm)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
RN  - EC 3.6.1.- (SMC4 protein, human)
SB  - IM
MH  - Adenosine Triphosphatases/genetics/*metabolism
MH  - Carcinoma, Hepatocellular/genetics/*metabolism/pathology
MH  - Cell Hypoxia/genetics
MH  - Cell Line, Tumor
MH  - *Cell Movement
MH  - *Cell Proliferation
MH  - Chromosomal Proteins, Non-Histone/genetics/*metabolism
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism
MH  - Liver Neoplasms/genetics/*metabolism/pathology
MH  - MicroRNAs/genetics/*metabolism
MH  - Neoplasm Proteins/genetics/*metabolism
MH  - RNA, Neoplasm/genetics/*metabolism
MH  - *Signal Transduction
PMC - PMC6885181
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2019/12/13 06:00
MHDA- 2020/04/24 06:00
PMCR- 2019/11/07
CRDT- 2019/12/13 06:00
PHST- 2019/06/02 00:00 [received]
PHST- 2019/07/24 00:00 [revised]
PHST- 2019/08/07 00:00 [accepted]
PHST- 2019/12/13 06:00 [entrez]
PHST- 2019/12/13 06:00 [pubmed]
PHST- 2020/04/24 06:00 [medline]
PHST- 2019/11/07 00:00 [pmc-release]
AID - 10.1155/2019/8983704 [doi]
PST - epublish
SO  - Biomed Res Int. 2019 Nov 7;2019:8983704. doi: 10.1155/2019/8983704. eCollection 
      2019.