PMID- 31828956 OWN - NLM STAT- MEDLINE DCOM- 20210426 LR - 20210426 IS - 2045-7634 (Electronic) IS - 2045-7634 (Linking) VI - 9 IP - 3 DP - 2020 Feb TI - Effect of interval between preoperative radiotherapy and surgery on clinical outcome and radiation proctitis in rectal cancer from FOWARC trial. PG - 912-919 LID - 10.1002/cam4.2755 [doi] AB - OBJECTIVE: The aim of this study was to evaluate the effect of the interval between CRT and surgery on radiation proctitis, the pathologic response, and postoperative morbidity. METHODS: This was a cohort study from a phase III, randomized controlled trial (FOWARC study, NCT01211210). Data were retrieved from the leading center of the trial. Patients were divided into the short-interval (7 weeks) group. The rate of radiation proctitis, pathologic complete regression (pCR) and morbidities were calculated for each group. Multivariate analysis was used to verify the impact of interval on radiation proctitis. RESULTS: Surgery was performed in 60 patients after an interval of 7 weeks. The two groups according to interval were comparable in terms of baseline demographic and clinicotherapeutic characteristics. Radiation proctitis was identified by imaging in 9 (15.0%) patients in short-interval group and in 31 (32.0%) patients in long-interval group (P = .018). Multivariate analysis confirmed the correlation between long interval and radiation proctitis (P = .018). The long interval was significantly associated with longer median operation time compared to the short interval (P = .022). The rates of pCR and postoperative complications were not different between two groups. CONCLUSIONS: A longer interval after CRT may be associated with higher rate of radiation proctitis and longer operation time. Moreover it did not increase the rate of pCR. CI - (c) 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. FAU - Cheng, Yi-Kan AU - Cheng YK AD - Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China. FAU - Qin, Qi-Yuan AU - Qin QY AD - Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. AD - Guangdong Institute of Gastroenterology, Guangzhou, People's Republic of China. AD - Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. FAU - Huang, Xiao-Yan AU - Huang XY AD - Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. AD - Guangdong Institute of Gastroenterology, Guangzhou, People's Republic of China. AD - Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. FAU - Lan, Ping AU - Lan P AD - Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. AD - Guangdong Institute of Gastroenterology, Guangzhou, People's Republic of China. AD - Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. FAU - Wang, Lei AU - Wang L AD - Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. AD - Guangdong Institute of Gastroenterology, Guangzhou, People's Republic of China. AD - Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. FAU - Gao, Xiang AU - Gao X AD - Department of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. FAU - Ma, Teng-Hui AU - Ma TH AUID- ORCID: 0000-0003-4547-865X AD - Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. AD - Guangdong Institute of Gastroenterology, Guangzhou, People's Republic of China. AD - Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. LA - eng PT - Clinical Trial, Phase III PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20191212 PL - United States TA - Cancer Med JT - Cancer medicine JID - 101595310 RN - 0 (Organoplatinum Compounds) RN - Q573I9DVLP (Leucovorin) RN - U3P01618RT (Fluorouracil) RN - Folfox protocol SB - IM MH - Adult MH - Aged MH - Antineoplastic Combined Chemotherapy Protocols/therapeutic use MH - Chemoradiotherapy, Adjuvant/adverse effects/methods MH - Cohort Studies MH - Dose Fractionation, Radiation MH - Female MH - Fluorouracil/therapeutic use MH - Humans MH - Intestinal Mucosa/diagnostic imaging/radiation effects/surgery MH - Leucovorin/therapeutic use MH - Male MH - Middle Aged MH - Neoadjuvant Therapy/*adverse effects/methods MH - Organoplatinum Compounds/therapeutic use MH - Proctectomy/*statistics & numerical data MH - Proctitis/diagnosis/*epidemiology/etiology MH - Radiation Injuries/diagnosis/*epidemiology/etiology MH - Rectal Neoplasms/mortality/*therapy MH - Rectum/diagnostic imaging/radiation effects/surgery MH - Time Factors MH - Time-to-Treatment/*statistics & numerical data MH - Treatment Outcome PMC - PMC6997091 OTO - NOTNLM OT - FOWARC clinical trial OT - interval between RCT and surgery OT - pathologic complete regression OT - radiation proctitis OT - rectal cancer COIS- We declare that we have no conflicts of interest. EDAT- 2019/12/13 06:00 MHDA- 2021/04/27 06:00 PMCR- 2019/12/12 CRDT- 2019/12/13 06:00 PHST- 2019/06/09 00:00 [received] PHST- 2019/10/24 00:00 [revised] PHST- 2019/10/28 00:00 [accepted] PHST- 2019/12/13 06:00 [pubmed] PHST- 2021/04/27 06:00 [medline] PHST- 2019/12/13 06:00 [entrez] PHST- 2019/12/12 00:00 [pmc-release] AID - CAM42755 [pii] AID - 10.1002/cam4.2755 [doi] PST - ppublish SO - Cancer Med. 2020 Feb;9(3):912-919. doi: 10.1002/cam4.2755. Epub 2019 Dec 12.