PMID- 31829235 OWN - NLM STAT- MEDLINE DCOM- 20200504 LR - 20240117 IS - 1532-429X (Electronic) IS - 1097-6647 (Print) IS - 1097-6647 (Linking) VI - 21 IP - 1 DP - 2019 Dec 12 TI - Comparison of different methods for the estimation of aortic pulse wave velocity from 4D flow cardiovascular magnetic resonance. PG - 75 LID - 10.1186/s12968-019-0584-x [doi] LID - 75 AB - BACKGROUND: Arterial pulse wave velocity (PWV) is associated with increased mortality in aging and disease. Several studies have shown the accuracy of applanation tonometry carotid-femoral PWV (Cf-PWV) and the relevance of evaluating central aorta stiffness using 2D cardiovascular magnetic resonance (CMR) to estimate PWV, and aortic distensibility-derived PWV through the theoretical Bramwell-Hill model (BH-PWV). Our aim was to compare various methods of aortic PWV (aoPWV) estimation from 4D flow CMR, in terms of associations with age, Cf-PWV, BH-PWV and left ventricular (LV) mass-to-volume ratio while evaluating inter-observer reproducibility and robustness to temporal resolution. METHODS: We studied 47 healthy subjects (49.5 +/- 18 years) who underwent Cf-PWV and CMR including aortic 4D flow CMR as well as 2D cine SSFP for BH-PWV and LV mass-to-volume ratio estimation. The aorta was semi-automatically segmented from 4D flow data, and mean velocity waveforms were estimated in 25 planes perpendicular to the aortic centerline. 4D flow CMR aoPWV was calculated: using velocity curves at two locations, namely ascending aorta (AAo) and distal descending aorta (DAo) aorta (S1, 2D-like strategy), or using all velocity curves along the entire aortic centreline (3D-like strategies) with iterative transit time (TT) estimates (S2) or a plane fitting of velocity curves systolic upslope (S3). For S1 and S2, TT was calculated using three approaches: cross-correlation (TTc), wavelets (TTw) and Fourier transforms (TTf). Intra-class correlation coefficients (ICC) and Bland-Altman biases (BA) were used to evaluate inter-observer reproducibility and effect of lower temporal resolution. RESULTS: 4D flow CMR aoPWV estimates were significantly (p < 0.05) correlated to the CMR-independent Cf-PWV, BH-PWV, age and LV mass-to-volume ratio, with the strongest correlations for the 3D-like strategy using wavelets TT (S2-TTw) (R = 0.62, 0.65, 0.77 and 0.52, respectively, all p < 0.001). S2-TTw was also highly reproducible (ICC = 0.99, BA = 0.09 m/s) and robust to lower temporal resolution (ICC = 0.97, BA = 0.15 m/s). CONCLUSIONS: Reproducible 4D flow CMR aoPWV estimates can be obtained using full 3D aortic coverage. Such 4D flow CMR stiffness measures were significantly associated with Cf-PWV, BH-PWV, age and LV mass-to-volume ratio, with a slight superiority of the 3D strategy using wavelets transit time (S2-TTw). FAU - Houriez-Gombaud-Saintonge, Sophia AU - Houriez-Gombaud-Saintonge S AD - Sorbonne Universite, INSERM, CNRS, Laboratoire d'Imagerie Biomedicale (LIB), 75006, Paris, France. AD - ESME Sudria Research Lab, Paris, France. AD - Institute of Cardiometabolism and Nutrition (ICAN), Paris, France. FAU - Mousseaux, Elie AU - Mousseaux E AD - Hopital Europeen Georges Pompidou, Paris, France. FAU - Bargiotas, Ioannis AU - Bargiotas I AD - CMLA, ENS Cachan, CNRS, Universite Paris-Saclay, 94235, Cachan, France. FAU - De Cesare, Alain AU - De Cesare A AD - Sorbonne Universite, INSERM, CNRS, Laboratoire d'Imagerie Biomedicale (LIB), 75006, Paris, France. AD - Institute of Cardiometabolism and Nutrition (ICAN), Paris, France. FAU - Dietenbeck, Thomas AU - Dietenbeck T AD - Sorbonne Universite, INSERM, CNRS, Laboratoire d'Imagerie Biomedicale (LIB), 75006, Paris, France. AD - Institute of Cardiometabolism and Nutrition (ICAN), Paris, France. FAU - Bouaou, Kevin AU - Bouaou K AD - Sorbonne Universite, INSERM, CNRS, Laboratoire d'Imagerie Biomedicale (LIB), 75006, Paris, France. AD - Institute of Cardiometabolism and Nutrition (ICAN), Paris, France. FAU - Redheuil, Alban AU - Redheuil A AD - Sorbonne Universite, INSERM, CNRS, Laboratoire d'Imagerie Biomedicale (LIB), 75006, Paris, France. AD - Institute of Cardiometabolism and Nutrition (ICAN), Paris, France. FAU - Soulat, Gilles AU - Soulat G AD - Hopital Europeen Georges Pompidou, Paris, France. FAU - Giron, Alain AU - Giron A AD - Sorbonne Universite, INSERM, CNRS, Laboratoire d'Imagerie Biomedicale (LIB), 75006, Paris, France. FAU - Gencer, Umit AU - Gencer U AD - Hopital Europeen Georges Pompidou, Paris, France. FAU - Craiem, Damian AU - Craiem D AD - Universidad Favaloro-CONICET, IMeTTyB, Buenos Aires, Argentina. FAU - Messas, Emmanuel AU - Messas E AD - Hopital Europeen Georges Pompidou, Paris, France. FAU - Bollache, Emilie AU - Bollache E AD - Sorbonne Universite, INSERM, CNRS, Laboratoire d'Imagerie Biomedicale (LIB), 75006, Paris, France. AD - Institute of Cardiometabolism and Nutrition (ICAN), Paris, France. FAU - Chenoune, Yasmina AU - Chenoune Y AD - ESME Sudria Research Lab, Paris, France. FAU - Kachenoura, Nadjia AU - Kachenoura N AD - Sorbonne Universite, INSERM, CNRS, Laboratoire d'Imagerie Biomedicale (LIB), 75006, Paris, France. nadjia.kachenoura@inserm.fr. AD - Institute of Cardiometabolism and Nutrition (ICAN), Paris, France. nadjia.kachenoura@inserm.fr. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191212 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 SB - IM MH - Adult MH - Age Factors MH - Aged MH - Aorta/*diagnostic imaging/physiology MH - Blood Flow Velocity MH - Female MH - Healthy Volunteers MH - Humans MH - Image Interpretation, Computer-Assisted MH - *Magnetic Resonance Angiography MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Observer Variation MH - Predictive Value of Tests MH - *Pulse Wave Analysis MH - Regional Blood Flow MH - Reproducibility of Results MH - Retrospective Studies MH - Time Factors MH - *Vascular Stiffness PMC - PMC6907267 OTO - NOTNLM OT - 4D flow CMR OT - Aging OT - Aortic stiffness OT - Pulse wave velocity COIS- The authors declare that they have no competing interests EDAT- 2019/12/13 06:00 MHDA- 2020/05/06 06:00 PMCR- 2019/12/12 CRDT- 2019/12/13 06:00 PHST- 2018/11/12 00:00 [received] PHST- 2019/10/22 00:00 [accepted] PHST- 2019/12/13 06:00 [entrez] PHST- 2019/12/13 06:00 [pubmed] PHST- 2020/05/06 06:00 [medline] PHST- 2019/12/12 00:00 [pmc-release] AID - S1097-6647(23)00248-X [pii] AID - 584 [pii] AID - 10.1186/s12968-019-0584-x [doi] PST - epublish SO - J Cardiovasc Magn Reson. 2019 Dec 12;21(1):75. doi: 10.1186/s12968-019-0584-x.