PMID- 31829932
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20220411
IS  - 2105-0686 (Electronic)
IS  - 2105-0678 (Linking)
VI  - 213
IP  - 3-4
DP  - 2019
TI  - [Neurotrophic mechanisms of psychedelic therapy].
PG  - 121-129
LID - 10.1051/jbio/2019015 [doi]
AB  - Psychedelic drugs, often referred to as hallucinogens, are quite distinct from 
      other classes of psychotropic drugs. Although the subjective and behavioral 
      effects they induce are quite dramatic, they possess little addictive potential 
      when compared to nicotine, alcohol or opiates. Since the discovery of ketamine 
      antidepressant effects, there has been growing interest for these molecules. 
      Serotonergic psychedelics such as psilocybin and lysergic acid diethylamide (LSD) 
      are gaining attention as potential treatments for depression and addiction, 
      similarly to 3,4-methylenedioxymethamphetamine (MDMA) for post-traumatic stress 
      disorder (PTSD), and ibogaine for addiction. Although they possess distinct 
      pharmacological profiles, their kinetics of action are quite similar: the 
      therapeutic effects are felt within the hours following administration, and last 
      well beyond drug elimination by the organism. This strongly suggests the 
      induction of neurogenic and plastic mechanisms, including the involvement of 
      trophic factors. This review will explore the literature dealing with the effects 
      of psychedelics on neurotrophins, as well as the plastic adaptations that they 
      induce, in an attempt to understand their surprising therapeutic potential. We 
      will show that although ketamine and serotonergic psychedelics have affinity for 
      very different receptors (NMDA, 5-HT2A), they ultimately initiate similar plastic 
      adaptations in the prefrontal cortex through the involvement of the brain-derived 
      neurotrophic factor (BDNF). We will see that although MDMA uses the same 
      receptors as serotonergic psychedelics to alleviate PTSD symptoms, its effect on 
      BDNF levels seem paradoxical and quite different. Finally, we show how ibogaine 
      could exert its anti-addictive properties through a completely different 
      neurotrophic factor than other psychedelic drugs, the glial cell line-derived 
      neurotrophic factor (GDNF). While the current literature concerning the 
      psychiatric applications of psychedelic therapy is encouraging, it remains to be 
      determined whether their benefits could be obtained without their psychotomimetic 
      effects, or concerns over potential toxicity.
CI  - (c) Societe de Biologie, 2019.
FAU - Corne, Remi
AU  - Corne R
AD  - CNRS ERL 3649 << Neuroplasticite et therapies des addictions >>, UMR-S 1124, 
      Universite Paris Descartes, 4, avenue de l'Observatoire, 75006 Paris, France.
FAU - Mongeau, Raymond
AU  - Mongeau R
AD  - CNRS ERL 3649 << Neuroplasticite et therapies des addictions >>, UMR-S 1124, 
      Universite Paris Descartes, 4, avenue de l'Observatoire, 75006 Paris, France.
LA  - fre
PT  - Journal Article
PT  - Review
TT  - Utilisation des psychedeliques en psychiatrie : lien avec les neurotrophines.
DEP - 20191212
PL  - France
TA  - Biol Aujourdhui
JT  - Biologie aujourd'hui
JID - 101544020
RN  - 0 (Hallucinogens)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - 3S814I130U (Ibogaine)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Animals
MH  - Hallucinogens/*therapeutic use
MH  - Humans
MH  - Ibogaine/pharmacology/therapeutic use
MH  - Ketamine/pharmacology
MH  - Mental Disorders/etiology/therapy
MH  - Nerve Growth Factors/pharmacology/*physiology
MH  - Psychiatry/*methods/trends
MH  - Serotonin/pharmacology
MH  - Serotonin Agents/pharmacology
MH  - Substance-Related Disorders/drug therapy
OTO - NOTNLM
OT  - BDNF
OT  - LSD
OT  - addiction
OT  - depression
OT  - depression
OT  - ketamine
OT  - ketamine
EDAT- 2019/12/13 06:00
MHDA- 2020/05/19 06:00
CRDT- 2019/12/13 06:00
PHST- 2019/04/29 00:00 [received]
PHST- 2019/12/13 06:00 [entrez]
PHST- 2019/12/13 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
AID - jbio190015 [pii]
AID - 10.1051/jbio/2019015 [doi]
PST - ppublish
SO  - Biol Aujourdhui. 2019;213(3-4):121-129. doi: 10.1051/jbio/2019015. Epub 2019 Dec 
      12.