PMID- 31830874
OWN - NLM
STAT- MEDLINE
DCOM- 20201207
LR  - 20210110
IS  - 2047-9980 (Electronic)
IS  - 2047-9980 (Linking)
VI  - 8
IP  - 24
DP  - 2019 Dec 17
TI  - Feasibility and Efficacy of His Bundle Pacing or Left Bundle Pacing Combined With 
      Atrioventricular Node Ablation in Patients With Persistent Atrial Fibrillation 
      and Implantable Cardioverter-Defibrillator Therapy.
PG  - e014253
LID - 10.1161/JAHA.119.014253 [doi]
LID - e014253
AB  - Background Persistent atrial fibrillation may lead to a higher probability of 
      inappropriate shocks in heart failure patients with an implantable 
      cardioverter-defibrillator (ICD). The aim of this study was to evaluate the 
      impact of His-Purkinje conduction system pacing combined with atrioventricular 
      node ablation in improving heart function and preventing inappropriate shock 
      therapy in these patients. Methods and Results A total of 86 consecutive patients 
      with persistent atrial fibrillation and heart failure who had indications for ICD 
      implantation were enrolled from January 2010 to March 2018. His-Purkinje 
      conduction system pacing with ICD and atrioventricular node ablation was 
      attempted in 55 patients, and the remaining patients underwent ICD implantation 
      only. Left ventricular (LV) ejection fraction, LV end-systolic volume, New York 
      Heart Association (NYHA) classification, shock therapies, and drug therapy were 
      assessed during follow-up. Overall, 31 patients received ICD implantation with 
      optimal drug therapy (group 1). atrioventricular node ablation combined with 
      His-Purkinje conduction system pacing was successfully achieved in 52 patients 
      (group 2). During follow-up, patients in group 2 had lower incidence of 
      inappropriate shock (15.6% versus 0%, P<0.01) and adverse events (P=0.011). 
      Meanwhile, improvement in LV ejection fraction and reduction in LV end-systolic 
      volume were significantly higher in group 2 than in group 1 (15% versus 3%, 
      P<0.001; and 40 versus 2 mL, P<0.01, respectively). NYHA functional class 
      improved in both groups from a baseline 2.57+/-0.68 to 1.73+/-0.74 in group 1 and 
      2.73+/-0.59 to 1.42+/-0.53 in group 2 (P<0.01). Conclusions His-Purkinje conduction 
      system pacing combined with atrioventricular node ablation is feasible and safe 
      with a high success rate in persistent atrial fibrillation patients with heart 
      failure and ICD indication. It can significantly reduce the incidence of 
      inappropriate shocks and improve LV function.
FAU - Wang, Songjie
AU  - Wang S
AD  - Department of Cardiology the First Affiliated Hospital of Wenzhou Medical 
      University Wenzhou China.
AD  - Key Lab of Cardiovascular Disease of Wenzhou Wenzhou China.
FAU - Wu, Shengjie
AU  - Wu S
AD  - Department of Cardiology the First Affiliated Hospital of Wenzhou Medical 
      University Wenzhou China.
AD  - Key Lab of Cardiovascular Disease of Wenzhou Wenzhou China.
FAU - Xu, Lei
AU  - Xu L
AD  - Department of Cardiology the First Affiliated Hospital of Wenzhou Medical 
      University Wenzhou China.
AD  - Key Lab of Cardiovascular Disease of Wenzhou Wenzhou China.
FAU - Xiao, Fangyi
AU  - Xiao F
AD  - Department of Cardiology the First Affiliated Hospital of Wenzhou Medical 
      University Wenzhou China.
AD  - Key Lab of Cardiovascular Disease of Wenzhou Wenzhou China.
FAU - Whinnett, Zachary I
AU  - Whinnett ZI
AD  - National Heart and Lung Institute Imperial College London United Kingdom.
FAU - Vijayaraman, Pugazhendhi
AU  - Vijayaraman P
AD  - Geisinger Heart Institute Wilkes Barre PA.
FAU - Su, Lan
AU  - Su L
AD  - Department of Cardiology the First Affiliated Hospital of Wenzhou Medical 
      University Wenzhou China.
AD  - Key Lab of Cardiovascular Disease of Wenzhou Wenzhou China.
FAU - Huang, Weijian
AU  - Huang W
AD  - Department of Cardiology the First Affiliated Hospital of Wenzhou Medical 
      University Wenzhou China.
AD  - Key Lab of Cardiovascular Disease of Wenzhou Wenzhou China.
LA  - eng
GR  - CS/15/3/31405/BHF_/British Heart Foundation/United Kingdom
GR  - FS/13/44/30291/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191213
PL  - England
TA  - J Am Heart Assoc
JT  - Journal of the American Heart Association
JID - 101580524
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*therapy
MH  - Atrioventricular Node/*surgery
MH  - *Bundle of His
MH  - Cardiac Pacing, Artificial/*methods
MH  - Case-Control Studies
MH  - *Catheter Ablation
MH  - Combined Modality Therapy
MH  - *Defibrillators, Implantable
MH  - Feasibility Studies
MH  - Female
MH  - Heart Failure/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Treatment Outcome
PMC - PMC6951078
OTO - NOTNLM
OT  - His bundle pacing
OT  - atrial fibrillation
OT  - atrioventricular node ablation
OT  - inappropriate shock
OT  - left bundle branch pacing
EDAT- 2019/12/14 06:00
MHDA- 2020/12/15 06:00
PMCR- 2019/12/17
CRDT- 2019/12/14 06:00
PHST- 2019/12/14 06:00 [entrez]
PHST- 2019/12/14 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2019/12/17 00:00 [pmc-release]
AID - JAH34651 [pii]
AID - 10.1161/JAHA.119.014253 [doi]
PST - ppublish
SO  - J Am Heart Assoc. 2019 Dec 17;8(24):e014253. doi: 10.1161/JAHA.119.014253. Epub 
      2019 Dec 13.