PMID- 31830898
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20231020
IS  - 1471-2156 (Electronic)
IS  - 1471-2156 (Linking)
VI  - 20
IP  - 1
DP  - 2019 Dec 12
TI  - First evaluation of resistance to both a California OsHV-1 variant and a French 
      OsHV-1 microvariant in Pacific oysters.
PG  - 96
LID - 10.1186/s12863-019-0791-3 [doi]
LID - 96
AB  - BACKGROUND: Variants of the Ostreid herpesvirus 1 (OsHV-1) cause high losses of 
      Pacific oysters globally, including in Tomales Bay, California, USA. A suite of 
      new variants, the OsHV-1 microvariants (muvars), cause very high mortalities of 
      Pacific oysters in major oyster-growing regions outside of the United States. 
      There are currently no known Pacific oysters in the United States that are 
      resistant to OsHV-1 as resistance has yet to be evaluated in these oysters. As 
      part of an effort to begin genetic selection for resistance to OsHV-1, 71 
      families from the Molluscan Broodstock Program, a US West Coast Pacific oyster 
      breeding program, were screened for survival after exposure to OsHV-1 in Tomales 
      Bay. They were also tested in a quarantine laboratory in France where they were 
      exposed to a French OsHV-1 microvariant using a plate assay, with survival 
      recorded from three to seven days post-infection. RESULTS: Significant 
      heritability for survival were found for all time points in the plate assay and 
      in the survival phenotype from a single mortality count in Tomales Bay. Genetic 
      correlations between survival against the French OsHV-1 muvar in the plate assay 
      and the Tomales Bay variant in the field trait were weak or non-significant. 
      CONCLUSIONS: Future breeding efforts will seek to validate the potential of 
      genetic improvement for survival to OsHV-1 through selection using the Molluscan 
      Broodstock Program oysters. The lack of a strong correlation in survival between 
      OsHV-1 variants under this study's exposure conditions may require 
      independent selection pressure for survival to each variant in order to make 
      simultaneous genetic gains in resistance.
FAU - Divilov, Konstantin
AU  - Divilov K
AUID- ORCID: 0000-0001-8962-7085
AD  - Department of Fisheries and Wildlife, Coastal Oregon Marine Experiment Station, 
      Oregon State University, Hatfield Marine Science Center, Newport, Oregon, USA. 
      divilovk@oregonstate.edu.
FAU - Schoolfield, Blaine
AU  - Schoolfield B
AD  - Department of Fisheries and Wildlife, Coastal Oregon Marine Experiment Station, 
      Oregon State University, Hatfield Marine Science Center, Newport, Oregon, USA.
FAU - Morga, Benjamin
AU  - Morga B
AD  - Laboratoire de Genetique et Pathologie des Mollusques Marins, Ifremer, La 
      Tremblade, France.
FAU - Degremont, Lionel
AU  - Degremont L
AD  - Laboratoire de Genetique et Pathologie des Mollusques Marins, Ifremer, La 
      Tremblade, France.
FAU - Burge, Colleen A
AU  - Burge CA
AD  - Institute of Marine and Environmental Technology, University of Maryland 
      Baltimore County, Baltimore, Maryland, USA.
FAU - Mancilla Cortez, Daniel
AU  - Mancilla Cortez D
AD  - Hog Island Oyster Co., Marshall, California, USA.
FAU - Friedman, Carolyn S
AU  - Friedman CS
AD  - School of Aquatic and Fishery Sciences, University of Washington, Seattle, 
      Washington, USA.
FAU - Fleener, Gary B
AU  - Fleener GB
AD  - Hog Island Oyster Co., Marshall, California, USA.
FAU - Dumbauld, Brett R
AU  - Dumbauld BR
AD  - United States Department of Agriculture-Agricultural Research Service, Hatfield 
      Marine Science Center, Newport, Oregon, USA.
FAU - Langdon, Chris
AU  - Langdon C
AD  - Department of Fisheries and Wildlife, Coastal Oregon Marine Experiment Station, 
      Oregon State University, Hatfield Marine Science Center, Newport, Oregon, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20191212
PL  - England
TA  - BMC Genet
JT  - BMC genetics
JID - 100966978
RN  - Ostreid herpesvirus 1
SB  - IM
MH  - Animals
MH  - Breeding
MH  - California
MH  - Crassostrea/genetics/*growth & development/virology
MH  - DNA Viruses/classification/*genetics
MH  - *Disease Resistance
MH  - France
MH  - Genetic Variation
MH  - Mortality
MH  - Selection, Genetic
PMC - PMC6909534
OTO - NOTNLM
OT  - Breeding
OT  - Crassostrea gigas
OT  - Heritability
OT  - Ostreid herpesvirus 1
COIS- The authors declare that they have no competing interests.
EDAT- 2019/12/14 06:00
MHDA- 2020/05/19 06:00
PMCR- 2019/12/12
CRDT- 2019/12/14 06:00
PHST- 2019/04/15 00:00 [received]
PHST- 2019/11/21 00:00 [accepted]
PHST- 2019/12/14 06:00 [entrez]
PHST- 2019/12/14 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2019/12/12 00:00 [pmc-release]
AID - 10.1186/s12863-019-0791-3 [pii]
AID - 791 [pii]
AID - 10.1186/s12863-019-0791-3 [doi]
PST - epublish
SO  - BMC Genet. 2019 Dec 12;20(1):96. doi: 10.1186/s12863-019-0791-3.