PMID- 31831537
OWN - NLM
STAT- MEDLINE
DCOM- 20201104
LR  - 20201104
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 9
IP  - 12
DP  - 2019 Dec 11
TI  - Systematic review and meta-analysis of the prognosis and prognostic factors of 
      interstitial pneumonia with autoimmune features.
PG  - e031444
LID - 10.1136/bmjopen-2019-031444 [doi]
LID - e031444
AB  - OBJECTIVE: To clarify the prognosis and prognostic factors of interstitial 
      pneumonia with autoimmune features (IPAF) in comparison to idiopathic pulmonary 
      fibrosis (IPF), the most common idiopathic interstitial pneumonia, and connective 
      tissue disease-associated interstitial pneumonia (CTD-IP). DESIGN: A systematic 
      review and meta-analysis. DATA SOURCES: Electronic databases such as Medline and 
      Embase were searched from 2015 through 6 September 2019. ELIGIBILITY CRITERIA FOR 
      SELECTING STUDIES: Primary studies that comparatively investigated the prognosis 
      or prognostic factors of IPAF were eligible. DATA EXTRACTION AND ANALYSIS: Two 
      reviewers extracted relevant data and assessed the risk of bias independently. A 
      meta-analysis was conducted using a random-effects model. The quality of 
      presented evidence was assessed by the Grades of Recommendation, Assessment, 
      Development, and Evaluation system. RESULTS: Out of a total of 656 records 
      retrieved, 12 studies were reviewed. The clinical features of IPAF were diverse 
      between studies, which included a radiological and/or pathological usual 
      interstitial pneumonia (UIP) pattern of between 0% and 73.8%. All studies 
      contained some risk of bias. There was no significant difference of all-cause 
      mortality between IPAF-UIP and IPF in all studies, although the prognosis of IPAF 
      in contrast to IPF or CTD-IP varied between studies depending on the proportion 
      of UIP pattern. Among the potential prognostic factors identified, age was 
      significantly associated with all-cause mortality of IPAF by a pooled analysis of 
      univariate results with a hazard ratio (HR) of 1.06 (95% confidence interval (CI) 
      1.04 to 1.07). The adjusted effect of age was also significant in all studies. 
      The quality of presented evidence was deemed as very low. CONCLUSION: There was 
      no significant difference of all-cause mortality between IPAF-UIP and IPF. Age 
      was deemed as a prognostic factor for all-cause mortality of IPAF. The findings 
      should be interpreted cautiously due to the low quality of the presented 
      evidence. PROSPERO REGISTRATION NUMBER: CRD42018115870.
CI  - (c) Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Kamiya, Hiroyuki
AU  - Kamiya H
AUID- ORCID: 0000-0001-5623-1279
AD  - School of Population and Global Health, University of Western Australia, Crawley, 
      Western Australia, Australia mlb04194@nifty.com.
FAU - Panlaqui, Ogee Mer
AU  - Panlaqui OM
AD  - Department of Intensive Care Medicine, Northern Hospital, Epping, Victoria, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20191211
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Autoimmune Diseases/diagnostic imaging/*mortality/pathology
MH  - Cause of Death
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/diagnostic imaging/mortality/pathology
MH  - Lung/diagnostic imaging/pathology
MH  - Lung Diseases, Interstitial/diagnostic imaging/*mortality/pathology
MH  - Prognosis
MH  - Tomography, X-Ray Computed
MH  - Undifferentiated Connective Tissue Diseases/diagnostic 
      imaging/mortality/pathology
PMC - PMC6924795
OTO - NOTNLM
OT  - Interstitial pneumonia with autoimmune features
OT  - meta-analysis
OT  - prognosis
OT  - review
COIS- Competing interests: None declared.
EDAT- 2019/12/14 06:00
MHDA- 2020/11/05 06:00
PMCR- 2019/12/11
CRDT- 2019/12/14 06:00
PHST- 2019/12/14 06:00 [entrez]
PHST- 2019/12/14 06:00 [pubmed]
PHST- 2020/11/05 06:00 [medline]
PHST- 2019/12/11 00:00 [pmc-release]
AID - bmjopen-2019-031444 [pii]
AID - 10.1136/bmjopen-2019-031444 [doi]
PST - epublish
SO  - BMJ Open. 2019 Dec 11;9(12):e031444. doi: 10.1136/bmjopen-2019-031444.