PMID- 31832060
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1660-3796 (Print)
IS  - 1660-3818 (Electronic)
IS  - 1660-3796 (Linking)
VI  - 46
IP  - 5
DP  - 2019 Oct
TI  - HLA Matching in Pediatric Stem Cell Transplantation.
PG  - 348-355
LID - 10.1159/000502422 [doi]
AB  - For several malignant and nonmalignant disorders such as leukemias, lymphomas, or 
      inborn errors of hematopoiesis, stem cell transplantation is the only curative 
      option. Depending on the underlying cause of the disease, the conditioning 
      regimens, source of the stem cells, and graft composition may vary. Possible stem 
      cell donors are selected from databases considering existing major 
      histocompatibility genes of the donor and the recipient. This is currently 
      performed by matching human leukocyte antigen (HLA)-A, -B, and -C for class I, as 
      well as HLA-DRB1 and -DQB1 for class II. Stem cell transplantation for 
      nonmalignant disorders is a specialty of pediatrics. While algorithms for donor 
      selection in these cases are generally similar, the objective of optimizing a 
      possible graft-versus-leukemia effect is less important. In this article, we aim 
      to provide an overview on the current methods for HLA typing and the algorithms 
      for HLA matching. We also address ethical aspects regarding children and minors 
      as stem cell donors.
CI  - Copyright (c) 2019 by S. Karger AG, Basel.
FAU - Eyrich, Matthias
AU  - Eyrich M
AD  - University Children's Hospital, University Hospital Wurzburg, Wurzburg, Germany.
FAU - Schulze, Harald
AU  - Schulze H
AD  - Institute of Experimental Biomedicine, Chair I, University Hospital Wurzburg, 
      Wurzburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190828
PL  - Switzerland
TA  - Transfus Med Hemother
JT  - Transfusion medicine and hemotherapy : offizielles Organ der Deutschen 
      Gesellschaft fur Transfusionsmedizin und Immunhamatologie
JID - 101176417
PMC - PMC6876600
OTO - NOTNLM
OT  - Donor selection
OT  - HLA matching
OT  - Stem cell transplantation
COIS- The authors have no conflicts of interest to declare.
EDAT- 2019/12/14 06:00
MHDA- 2019/12/14 06:01
PMCR- 2019/08/28
CRDT- 2019/12/14 06:00
PHST- 2019/05/20 00:00 [received]
PHST- 2019/07/23 00:00 [accepted]
PHST- 2019/12/14 06:00 [entrez]
PHST- 2019/12/14 06:00 [pubmed]
PHST- 2019/12/14 06:01 [medline]
PHST- 2019/08/28 00:00 [pmc-release]
AID - tmh-0046-0348 [pii]
AID - 10.1159/000502422 [doi]
PST - ppublish
SO  - Transfus Med Hemother. 2019 Oct;46(5):348-355. doi: 10.1159/000502422. Epub 2019 
      Aug 28.