PMID- 31832417
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 7
IP  - 23
DP  - 2019 Dec 6
TI  - Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of 
      the literature.
PG  - 4119-4129
LID - 10.12998/wjcc.v7.i23.4119 [doi]
AB  - BACKGROUND: Pancreatic mixed serous-neuroendocrine neoplasms (MSNNs) are mixed 
      tumors containing two components with different pathologies, namely, pancreatic 
      serous cystic neoplasm (PSCN) and pancreatic neuroendocrine tumor (PanNET). For 
      MSNNs, diffuse PSCN involving the whole pancreas is extremely rare, with only 
      eight previous case reports. CASE SUMMARY: A 45-year-old Chinese woman, with a 
      free previous medical history and no obvious symptoms, was found to have a 
      pancreatic neoplasm and admitted to our hospital for further diagnosis in March 
      2018. Abdominal palpation revealed a painless, mobile mass in the epigastrium, 
      and no abnormalities were observed in an examination of the nervous system and 
      ocular system. A computed tomography scan showed multiple cystic lesions 
      involving the whole pancreas ranging in diameter from 0.4 to 2 cm and also 
      revealed an enhanced mass, 2.2 cm in diameter, in the head of the pancreas. 
      Moreover, multiple cysts were found in the kidneys bilaterally, and the right 
      lobe of the liver contained a small cyst. A Whipple operation with total 
      pancreatectomy and splenectomy was performed. A diagnosis of pancreatic MSNN was 
      established, consisting of diffuse serous microcystic cystadenoma with a 
      concomitant grade 2 PanNET. Of note, the patient had no personal or family 
      history of Von Hippel-Lindau syndrome or other disease. CONCLUSION: We report the 
      first case of MSNN with a diffuse PSCN component involving the entire pancreas in 
      a Chinese woman. It is important to be aware of its relationship with VHL 
      syndrome, and close clinical follow-up is recommended.
CI  - (c)The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Xu, Yue-Mei
AU  - Xu YM
AD  - Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China.
FAU - Li, Zhi-Wen
AU  - Li ZW
AD  - Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China.
FAU - Wu, Hong-Yan
AU  - Wu HY
AD  - Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China.
FAU - Fan, Xiang-Shan
AU  - Fan XS
AD  - Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China.
FAU - Sun, Qi
AU  - Sun Q
AD  - Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China. 
      blkqisun@qq.com.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC6906574
OTO - NOTNLM
OT  - Case report
OT  - Mixed serous-neuroendocrine neoplasm
OT  - Pancreatic neuroendocrine tumor
OT  - Pancreatic serous cystic neoplasm
OT  - Von Hippel-Lindau syndrome
COIS- Conflict-of-interest statement: The authors declare that they have no conflict of 
      interest.
EDAT- 2019/12/14 06:00
MHDA- 2019/12/14 06:01
PMCR- 2019/12/06
CRDT- 2019/12/14 06:00
PHST- 2019/08/22 00:00 [received]
PHST- 2019/10/14 00:00 [revised]
PHST- 2019/11/15 00:00 [accepted]
PHST- 2019/12/14 06:00 [entrez]
PHST- 2019/12/14 06:00 [pubmed]
PHST- 2019/12/14 06:01 [medline]
PHST- 2019/12/06 00:00 [pmc-release]
AID - 10.12998/wjcc.v7.i23.4119 [doi]
PST - ppublish
SO  - World J Clin Cases. 2019 Dec 6;7(23):4119-4129. doi: 10.12998/wjcc.v7.i23.4119.