PMID- 31832439
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231019
IS  - 2322-3480 (Print)
IS  - 2322-3480 (Electronic)
IS  - 2322-3480 (Linking)
VI  - 8
IP  - 2
DP  - 2019 Jul
TI  - The Association of HLA-A, B and DRB1 with Buerger's Disease.
PG  - 153-160
AB  - BACKGROUND: Thromboangiitis obliterans (TAO), also known as Burger's disease, is 
      a devastating disease affecting the arteries and veins of the upper and lower 
      distal limbs most commonly afflicting young male smokers of low socioeconomic 
      status. The expression of human leukocyte antigen (HLA)-A, B and -DRB1 genes have 
      been implicated in the pathogenesis of TAO. Our study aimed to examine the 
      association of different HLA-A, B and -DRB1 genes in TAO patients in the Iranian 
      population. METHODS: A case-control study examining 55 Iranian patients with TAO 
      and 500 healthy subjects was performed in Imam Reza hospital, Mashhad, Iran. The 
      prevalence of major histocompatibility complex (MHC) class I (-A, -B) and class 
      II (-DRB) alleles were determined for each participant. RESULTS: Our results 
      revealed the HLA-A*03 (odds ratio [OR]=5.394), HLA-A*24 (OR=5.143), HLA-A*31 
      (OR=4.251), HLA-A*11 (OR=3.034), HLA-B*27 (OR=6.680), HLA-B*15 (OR=3.959), 
      HLA-B*07 (OR=3.698), HLA-B*51 (OR=3.370), HLA-B*44 (OR=3.326), HLA-DRB1*16 
      (OR=20.583), HLADRB1* 04 (OR=8.960), HLA-DRB1*14 (OR=3.746), HLA-DRB1*03 
      (OR=2.303), and HLA-DRB1*15 (OR=2.111) alleles to occur at a significantly higher 
      frequency in TAO patients compared to controls (p<0.05). The HLA-A*25, HLA-A*66, 
      HLA-DRB1*08, HLA-DRB1*10, and HLA-DRB1*12 alleles resulted in infinite OR, and 
      was associated with an increased risk of TAO. However, the alleles HLA-A*30, 
      HLA-B*08, HLA-B*45, HLA-B*46, and HLA-B*53 were associated with a protective role 
      against TAO with an OR = 0. CONCLUSION: This is the first study examining the HLA 
      pattern in patients with Burger's disease in the Iranian population. Our findings 
      have revealed an association between HLA class I and II alleles with TAO.
FAU - Shapouri-Moghaddam, Abbas
AU  - Shapouri-Moghaddam A
AD  - Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Mohammadi, Mojgan
AU  - Mohammadi M
AD  - Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
AD  - Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Rahimi, Hamid Reza
AU  - Rahimi HR
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
AD  - Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Esmaeili, Habibolah
AU  - Esmaeili H
AD  - Social Determination of Health Research Center, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Mahmoudi, Mahmoud
AU  - Mahmoudi M
AD  - Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Saeed Modaghegh, Mohammad-Hadi
AU  - Saeed Modaghegh MH
AD  - Vascular and Endovascular Surgery Research Center, Imam Reza Hospital, Mashhad 
      University of Medical Sciences, Iran.
FAU - Tavakol Afshari, Jalil
AU  - Tavakol Afshari J
AD  - Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Rep Biochem Mol Biol
JT  - Reports of biochemistry & molecular biology
JID - 101637937
PMC - PMC6844607
OTO - NOTNLM
OT  - Buerger's disease
OT  - HLA-DNA typing
OT  - MHC
OT  - Polymerase chain reaction
OT  - Thromboangiitis obliterans
EDAT- 2019/12/14 06:00
MHDA- 2019/12/14 06:01
PMCR- 2019/07/01
CRDT- 2019/12/14 06:00
PHST- 2019/12/14 06:00 [entrez]
PHST- 2019/12/14 06:00 [pubmed]
PHST- 2019/12/14 06:01 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - rbmb-8-153 [pii]
PST - ppublish
SO  - Rep Biochem Mol Biol. 2019 Jul;8(2):153-160.