PMID- 31835423
OWN - NLM
STAT- MEDLINE
DCOM- 20200902
LR  - 20200902
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 9
IP  - 12
DP  - 2019 Dec 9
TI  - Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes.
LID - 10.3390/biom9120850 [doi]
LID - 850
AB  - The inflammasome is a multiprotein complex that acts to enhance inflammatory 
      responses by promoting the production and secretion of key cytokines. The 
      best-known inflammasome is the NLRP3 (nucleotide-binding oligomerization 
      domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome. The 
      evidence has shown that the NLRP3 inflammasome, IL-1beta, thioredoxin-interacting 
      protein (TXNIP), and pyroptosis play vital roles in the development of diabetes. 
      This review summarizes the regulation of type 1 diabetes mellitus (T1DM) and type 
      2 diabetes mellitus (T2DM) by NLRP3 via modulation of glucose tolerance, insulin 
      resistance, inflammation, and apoptosis mediated by endoplasmic reticulum stress 
      in adipose tissue. Moreover, NLRP3 participates in intestinal homeostasis and 
      inflammatory conditions, and NLRP3-deficient mice experience intestinal lesions. 
      The diversity of an individual's gut microbiome and the resultant microbial 
      metabolites determines the extent of their involvement in the physiological and 
      pathological mechanisms within the gut. As such, further study of the interaction 
      between the NLRP3 inflammasome and the complex intestinal environment in disease 
      development is warranted to discover novel therapies for the treatment of 
      diabetes.
FAU - Ding, Sujuan
AU  - Ding S
AUID- ORCID: 0000-0003-0017-680X
AD  - College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 
      410128, Hunan, China.
FAU - Xu, Sheng
AU  - Xu S
AD  - College of Life Sciences, Shandong Agricultural University, Tai'an 271018, 
      Shandong, China.
FAU - Ma, Yong
AU  - Ma Y
AD  - College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 
      410128, Hunan, China.
FAU - Liu, Gang
AU  - Liu G
AUID- ORCID: 0000-0002-9475-5134
AD  - College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 
      410128, Hunan, China.
AD  - Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic 
      Process, CAS Key Laboratory of Agro-ecological Processes in Subtropical Region, 
      Institute of Subtropical Agriculture, Chinese Academy of Sciences, National 
      Engineering Laboratory for Pollution Control and Waste Utilization in Livestock 
      and Poultry Production, Changsha 410125, Hunan, China.
FAU - Jang, Hongmei
AU  - Jang H
AD  - College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 
      410128, Hunan, China.
FAU - Fang, Jun
AU  - Fang J
AD  - College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 
      410128, Hunan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191209
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 1/immunology/*metabolism
MH  - Diabetes Mellitus, Type 2/immunology/*metabolism
MH  - Gastrointestinal Microbiome/immunology
MH  - Glucose Intolerance
MH  - Humans
MH  - Inflammasomes/*metabolism
MH  - Inflammation/metabolism
MH  - Insulin Resistance
MH  - Interleukin-1beta/metabolism
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
MH  - Pyroptosis/physiology
PMC - PMC6995523
OTO - NOTNLM
OT  - Glucose tolerance
OT  - NLRP3
OT  - diabetes
OT  - gut microbes
OT  - insulin resistance
COIS- All co-authors have seen and agree with the contents of the manuscript, and there 
      is no financial interest to report.
EDAT- 2019/12/15 06:00
MHDA- 2020/09/04 06:00
PMCR- 2019/12/01
CRDT- 2019/12/15 06:00
PHST- 2019/11/14 00:00 [received]
PHST- 2019/12/02 00:00 [revised]
PHST- 2019/12/02 00:00 [accepted]
PHST- 2019/12/15 06:00 [entrez]
PHST- 2019/12/15 06:00 [pubmed]
PHST- 2020/09/04 06:00 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - biom9120850 [pii]
AID - biomolecules-09-00850 [pii]
AID - 10.3390/biom9120850 [doi]
PST - epublish
SO  - Biomolecules. 2019 Dec 9;9(12):850. doi: 10.3390/biom9120850.