PMID- 31835690
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 8
IP  - 12
DP  - 2019 Dec 11
TI  - Efficacy Study of Anti-Endomysium Antibodies for Celiac Disease Diagnosis: A 
      Retrospective Study in a Spanish Pediatric Population.
LID - 10.3390/jcm8122179 [doi]
LID - 2179
AB  - The aim of this study was to assess the efficacy of anti-endomysium antibodies 
      (EMA) as a serological marker for celiac disease (CD) diagnosis in a pediatric 
      population. A retrospective study of pediatric patients who underwent a CD 
      serological markers study: EMA and anti-tissue transglutaminase antibodies 
      (anti-TG2). Clinical symptomatology, degree of histological lesion, human 
      leukocyte antigen (HLA) haplotype compatible with CD (HLA DQ2 and/or DQ8), and 
      final diagnosis were taken into account. We included 445 patients who were 
      classified in two groups according to the final diagnosis. Group 1: 232 children 
      with CD, 91.4% of whom exhibited small intestinal villous atrophy, 228 being 
      EMA-positive and four EMA-negative. Group 2: 213 children with a non-CD 
      diagnosis, 212 EMA negative and one EMA positive. Both antibodies, EMA and 
      anti-TG2, reached similar sensitivities, 98% and 99% respectively, while EMA had 
      a higher specificity (99%) than anti-TG2 (93%). By using both markers combined, 
      compared to using anti-TG2 alone, 5.7% of patients are better diagnosed. However, 
      when we compare the efficacy of EMA and anti-TG2 in asymptomatic and symptomatic 
      patients, the sensitivity of EMA is 98% irrespective of symptoms, thus higher 
      than for anti-TG2 >/=10 x upper limit of normal (ULN) (respectively 77% and 84%). 
      Our results support the use of EMA to increase CD diagnostic accuracy in a 
      non-biopsy approach, especially in asymptomatic children.
FAU - Roca, Maria
AU  - Roca M
AUID- ORCID: 0000-0001-8157-2446
AD  - Celiac Disease and Digestive Immunopathology Unit, Instituto de Investigacion 
      Sanitaria La Fe, 46026 Valencia, Spain.
FAU - Donat, Ester
AU  - Donat E
AD  - Celiac Disease and Digestive Immunopathology Unit, Instituto de Investigacion 
      Sanitaria La Fe, 46026 Valencia, Spain.
AD  - Pediatric Gastrohepathology Unit, Hospital Universitario y Politecnico La Fe, 
      46026 Valencia, Spain.
FAU - Marco-Maestud, Natalia
AU  - Marco-Maestud N
AD  - Celiac Disease and Digestive Immunopathology Unit, Instituto de Investigacion 
      Sanitaria La Fe, 46026 Valencia, Spain.
FAU - Masip, Etna
AU  - Masip E
AD  - Celiac Disease and Digestive Immunopathology Unit, Instituto de Investigacion 
      Sanitaria La Fe, 46026 Valencia, Spain.
AD  - Pediatric Gastrohepathology Unit, Hospital Universitario y Politecnico La Fe, 
      46026 Valencia, Spain.
FAU - Hervas-Marin, David
AU  - Hervas-Marin D
AUID- ORCID: 0000-0003-0635-4961
AD  - Statistics Unit, Instituto de Investigacion Sanitaria La Fe, 46026 Valencia, 
      Spain.
FAU - Ramos, David
AU  - Ramos D
AD  - Pathology Service, Hospital Universitario y Politecnico La Fe, 46026 Valencia, 
      Spain.
FAU - Polo, Begona
AU  - Polo B
AD  - Celiac Disease and Digestive Immunopathology Unit, Instituto de Investigacion 
      Sanitaria La Fe, 46026 Valencia, Spain.
AD  - Pediatric Gastrohepathology Unit, Hospital Universitario y Politecnico La Fe, 
      46026 Valencia, Spain.
FAU - Ribes-Koninckx, Carmen
AU  - Ribes-Koninckx C
AD  - Celiac Disease and Digestive Immunopathology Unit, Instituto de Investigacion 
      Sanitaria La Fe, 46026 Valencia, Spain.
AD  - Pediatric Gastrohepathology Unit, Hospital Universitario y Politecnico La Fe, 
      46026 Valencia, Spain.
LA  - eng
PT  - Journal Article
DEP - 20191211
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6947542
OTO - NOTNLM
OT  - Celiac disease
OT  - anti-endomysium antibodies
OT  - anti-tissue transglutaminase antibodies
OT  - pediatric population
COIS- The authors declare no conflict of interest.
EDAT- 2019/12/15 06:00
MHDA- 2019/12/15 06:01
PMCR- 2019/12/11
CRDT- 2019/12/15 06:00
PHST- 2019/11/15 00:00 [received]
PHST- 2019/12/04 00:00 [revised]
PHST- 2019/12/09 00:00 [accepted]
PHST- 2019/12/15 06:00 [entrez]
PHST- 2019/12/15 06:00 [pubmed]
PHST- 2019/12/15 06:01 [medline]
PHST- 2019/12/11 00:00 [pmc-release]
AID - jcm8122179 [pii]
AID - jcm-08-02179 [pii]
AID - 10.3390/jcm8122179 [doi]
PST - epublish
SO  - J Clin Med. 2019 Dec 11;8(12):2179. doi: 10.3390/jcm8122179.