PMID- 31837212
OWN - NLM
STAT- MEDLINE
DCOM- 20210823
LR  - 20210823
IS  - 0125-877X (Print)
IS  - 0125-877X (Linking)
VI  - 38
IP  - 4
DP  - 2020 Dec
TI  - Dendritic cells as key players in systemic lupus erythematosus.
PG  - 225-232
LID - 10.12932/AP-070919-0639 [doi]
AB  - System lupus erythematosus (SLE) is a chronic autoimmune disorder affecting 
      multiple organs, and persistent disease activity is associated with increased 
      morbidity and mortality. Impairment of immune cell function and loss of immune 
      tolerance to self-antigens are significant determinants that trigger inflammation 
      and drive SLE pathogenesis. Dendritic cells (DCs) are the most potent 
      antigen-presenting cells that serve as a critical link between innate and 
      adaptive immune system. SLE development and pathogenesis are associated with 
      aberrant regulation in homeostasis and function of DCs, therefore, DC-targeted 
      therapies have become of importance for treatment of SLE and autoimmune diseases. 
      This review focus on the significance of DCs in promoting of SLE pathogenesis, 
      and further discuss the clinical potential of DCs in SLE therapy. The insights on 
      the roles of DCs in SLE will provide the improvement of treatment strategy for 
      SLE patients.
FAU - Kaewraemruaen, Chamraj
AU  - Kaewraemruaen C
AD  - Center of Excellence in Immunology and Immune-mediated Diseases, Faculty of 
      Medicine, Chulalongkorn University, Bangkok, 10330 Thailand.
FAU - Ritprajak, Patcharee
AU  - Ritprajak P
AD  - Research Unit in Integrative Immuno-Microbial Biochemistry and Bioresponsive 
      Nanomaterials, Faculty of Dentistry, Chulalongkorn University.
AD  - Department of Microbiology, Faculty of Dentistry, Chulalongkorn University, 
      Bangkok, 10330 Thailand.
FAU - Hirankarn, Nattiya
AU  - Hirankarn N
AD  - Center of Excellence in Immunology and Immune-mediated Diseases, Faculty of 
      Medicine, Chulalongkorn University, Bangkok, 10330 Thailand.
AD  - Department of Microbiology, Faculty of Medicine, Chulalongkorn University, 
      Bangkok, 10330, Thailand.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Thailand
TA  - Asian Pac J Allergy Immunol
JT  - Asian Pacific journal of allergy and immunology
JID - 8402034
SB  - IM
MH  - Animals
MH  - Autoimmunity
MH  - Cell Communication/genetics/immunology
MH  - Cell Plasticity/immunology
MH  - Combined Modality Therapy
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Disease Management
MH  - *Disease Susceptibility
MH  - Humans
MH  - Immune Tolerance
MH  - Lupus Erythematosus, Systemic/*etiology/*metabolism/pathology/therapy
MH  - Lymphocyte Activation/genetics/immunology
MH  - Lymphocytes/immunology/metabolism
MH  - Molecular Targeted Therapy
MH  - Treatment Outcome
EDAT- 2019/12/15 06:00
MHDA- 2021/08/24 06:00
CRDT- 2019/12/15 06:00
PHST- 2019/12/15 06:00 [pubmed]
PHST- 2021/08/24 06:00 [medline]
PHST- 2019/12/15 06:00 [entrez]
AID - 10.12932/AP-070919-0639 [doi]
PST - ppublish
SO  - Asian Pac J Allergy Immunol. 2020 Dec;38(4):225-232. doi: 
      10.12932/AP-070919-0639.