PMID- 31837635 OWN - NLM STAT- MEDLINE DCOM- 20200709 LR - 20200709 IS - 1872-8421 (Electronic) IS - 0165-5728 (Linking) VI - 339 DP - 2020 Feb 15 TI - Overlapping autoimmune syndrome: A case of concomitant anti-NMDAR encephalitis and myelin oligodendrocyte glycoprotein (MOG) antibody disease. PG - 577124 LID - S0165-5728(19)30544-2 [pii] LID - 10.1016/j.jneuroim.2019.577124 [doi] AB - Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system that commonly manifests as a complex neuropsychiatric syndrome. Antibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with a range of clinical presentations including acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis. The concurrence of NMDAR encephalitis and demyelinating syndromes is rare. We describe the case of a 29-year-old male with NMDAR encephalitis and overlapping MOG antibody disease. The aim of this report is to add to the growing knowledge of phenotypic characteristics of overlap syndromes as their clinical and prognostic features may differ from those of single antibody disease. CI - Copyright (c) 2019 Elsevier B.V. All rights reserved. FAU - Perez, Carlos A AU - Perez CA AD - Division of Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: carlos.a.perez@uth.tmc.edu. FAU - Agyei, Paunel AU - Agyei P AD - Division of Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA. FAU - Gogia, Bhanu AU - Gogia B AD - Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA. FAU - Harrison, Rebecca AU - Harrison R AD - Division of Cancer Medicine, Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. FAU - Samudralwar, Rohini AU - Samudralwar R AD - Division of Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA. LA - eng PT - Case Reports PT - Journal Article DEP - 20191206 PL - Netherlands TA - J Neuroimmunol JT - Journal of neuroimmunology JID - 8109498 RN - 0 (Autoantibodies) RN - 0 (Myelin-Oligodendrocyte Glycoprotein) SB - IM MH - Adult MH - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*blood/complications/*diagnostic imaging MH - Autoantibodies/*blood MH - Demyelinating Diseases/*blood/complications/*diagnostic imaging MH - Humans MH - Male MH - Myelin-Oligodendrocyte Glycoprotein/*blood OTO - NOTNLM OT - Autoimmune OT - Encephalitis OT - Myelin oligodendrocyte glycoprotein OT - N-methyl-d-aspartate receptor OT - Overlap syndrome EDAT- 2019/12/15 06:00 MHDA- 2020/07/10 06:00 CRDT- 2019/12/15 06:00 PHST- 2019/10/20 00:00 [received] PHST- 2019/12/05 00:00 [revised] PHST- 2019/12/05 00:00 [accepted] PHST- 2019/12/15 06:00 [pubmed] PHST- 2020/07/10 06:00 [medline] PHST- 2019/12/15 06:00 [entrez] AID - S0165-5728(19)30544-2 [pii] AID - 10.1016/j.jneuroim.2019.577124 [doi] PST - ppublish SO - J Neuroimmunol. 2020 Feb 15;339:577124. doi: 10.1016/j.jneuroim.2019.577124. Epub 2019 Dec 6.