PMID- 31837799
OWN - NLM
STAT- MEDLINE
DCOM- 20200505
LR  - 20200505
IS  - 1525-3198 (Electronic)
IS  - 0022-0302 (Linking)
VI  - 103
IP  - 2
DP  - 2020 Feb
TI  - Proteomic analysis of whey proteins in the colostrum and mature milk of Xinong 
      Saanen goats.
PG  - 1164-1174
LID - S0022-0302(19)31082-3 [pii]
LID - 10.3168/jds.2019-17159 [doi]
AB  - Xinong Saanen goats are among the major dairy goats in China, and their milk is 
      one of the major milk supplies for the Chinese dairy industry. To explore the 
      whey proteome of Xinong Saanen goat milk, we analyzed the whey proteins of goat 
      colostrum and mature milk using proteomic techniques. We identified a total of 
      314 and 524 proteins in goat colostrum and mature milk, respectively. Our data 
      showed the first 3 functional categories of signal, disulfide bond, and secreted 
      in both milk types. The most abundant Gene Ontology annotations in both milks 
      were the biological process of positive regulation of extracellular regulated 
      protein kinases (ERK)1 and ERK2 cascade; the cellular component of extracellular 
      exosome; and the molecular function of calcium ion binding. Goat colostrum whey 
      proteins showed more disease-related pathways, and mature milk showed more 
      pathways associated with metabolism. Moreover, we observed several pathways 
      involved in intestinal mucosal immunity only in colostrum. Protein-protein 
      interaction network and module analysis revealed that complement and coagulation 
      cascades and Staphylococcus aureus infection were significant in the whey 
      proteins of both milks, and carbon metabolism was more common for mature milk 
      than for colostrum. These findings could provide useful information for the use 
      of goat milk whey proteins in the Chinese dairy industry.
CI  - Copyright (c) 2020 American Dairy Science Association. Published by Elsevier Inc. 
      All rights reserved.
FAU - Sun, Yuxue
AU  - Sun Y
AD  - Key Laboratory of Dairy Science (Northeast Agricultural University), Ministry of 
      Education, Harbin, Heilongjiang, 150030, China; Department of Food Science, 
      College of Food Science and Engineering, Jilin University, Changchun, Jilin, 
      130062, China.
FAU - Wang, Cuina
AU  - Wang C
AD  - Key Laboratory of Dairy Science (Northeast Agricultural University), Ministry of 
      Education, Harbin, Heilongjiang, 150030, China; Department of Food Science, 
      College of Food Science and Engineering, Jilin University, Changchun, Jilin, 
      130062, China.
FAU - Sun, Xiaomeng
AU  - Sun X
AD  - Key Laboratory of Dairy Science (Northeast Agricultural University), Ministry of 
      Education, Harbin, Heilongjiang, 150030, China.
FAU - Guo, Mingruo
AU  - Guo M
AD  - Key Laboratory of Dairy Science (Northeast Agricultural University), Ministry of 
      Education, Harbin, Heilongjiang, 150030, China; Department of Nutrition and Food 
      Sciences, College of Agriculture and Life Sciences, University of Vermont, 
      Burlington 05405. Electronic address: mguo@uvm.edu.
LA  - eng
PT  - Journal Article
DEP - 20191216
PL  - United States
TA  - J Dairy Sci
JT  - Journal of dairy science
JID - 2985126R
RN  - 0 (Whey Proteins)
SB  - IM
MH  - Animals
MH  - China
MH  - Colostrum/*chemistry
MH  - Female
MH  - Gene Ontology
MH  - *Goats/genetics/metabolism
MH  - Milk/*chemistry
MH  - Pregnancy
MH  - Proteomics
MH  - Whey Proteins/*analysis
OTO - NOTNLM
OT  - Xinong Saanen goat
OT  - colostrum
OT  - mature milk
OT  - proteomics
OT  - whey protein
EDAT- 2019/12/16 06:00
MHDA- 2020/05/06 06:00
CRDT- 2019/12/16 06:00
PHST- 2019/06/25 00:00 [received]
PHST- 2019/10/29 00:00 [accepted]
PHST- 2019/12/16 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2019/12/16 06:00 [entrez]
AID - S0022-0302(19)31082-3 [pii]
AID - 10.3168/jds.2019-17159 [doi]
PST - ppublish
SO  - J Dairy Sci. 2020 Feb;103(2):1164-1174. doi: 10.3168/jds.2019-17159. Epub 2019 
      Dec 16.