PMID- 31838757
OWN - NLM
STAT- MEDLINE
DCOM- 20210309
LR  - 20210309
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 235
IP  - 6
DP  - 2020 Jun
TI  - Blood screening for heavy metals and organic pollutants in cancer patients 
      exposed to toxic waste in southern Italy: A pilot study.
PG  - 5213-5222
LID - 10.1002/jcp.29399 [doi]
AB  - In Italy, in the eastern area of the Campania region, the illegal dumping and 
      burning of waste have been documented, which could potentially affect the local 
      population's health. In particular, toxic waste exposure has been suggested to 
      associate with increased cancer development/mortality in these areas, although a 
      causal link has not yet been established. In this pilot study, we evaluated blood 
      levels of toxic heavy metals and persistent organic pollutants (POPs) in 95 
      patients with different cancer types residing in this area and in 27 healthy 
      individuals. While we did not find any significant correlation between the blood 
      levels of POPs and the provenance of the patients, we did observe high blood 
      concentrations of heavy metals in some municipalities, including Giugliano, where 
      many illegal waste disposal sites have previously been documented. Our results 
      showed that patients with different cancer types from Giugliano had higher blood 
      levels of heavy metals than healthy controls. Despite the obvious limitations of 
      this exploratory study, our preliminary observations encourage further research 
      assessing the possible association between exposure to hazardous waste, increased 
      blood metals, and increased risk of cancer.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Forte, Iris Maria
AU  - Forte IM
AD  - Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. 
      Pascale, I-80131, Napoli, Italy.
FAU - Indovina, Paola
AU  - Indovina P
AD  - Sbarro Institute for Cancer Research and Molecular Medicine, Center for 
      Biotechnology, College of Science and Technology, Temple University, 
      Philadelphia, Pennsylvania, PA 19122, USA.
FAU - Costa, Aurora
AU  - Costa A
AD  - Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. 
      Pascale, I-80131, Napoli, Italy.
FAU - Iannuzzi, Carmelina Antonella
AU  - Iannuzzi CA
AD  - Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. 
      Pascale, I-80131, Napoli, Italy.
FAU - Costanzo, Luigi
AU  - Costanzo L
AD  - ASL Napoli 2 Nord, Via Lupoli, Frattamaggiore, Naples, Italy.
FAU - Marfella, Antonio
AU  - Marfella A
AD  - SS Farmacologia clinica e Farmacoeconomia-Istituto Nazionale 
      Tumori-IRCCS-Fondazione G. Pascale, I-80131, Napoli, Italy.
FAU - Montagnaro, Serena
AU  - Montagnaro S
AD  - Department of Veterinary Medicine and Animal Productions, University of Naples 
      "Federico II,", Napoli, Italy.
FAU - Botti, Gerardo
AU  - Botti G
AD  - Scientific Direction, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 
      I-80131, Napoli, Italy.
FAU - Bucci, Enrico
AU  - Bucci E
AD  - Sbarro Institute for Cancer Research and Molecular Medicine, Center for 
      Biotechnology, College of Science and Technology, Temple University, 
      Philadelphia, Pennsylvania, PA 19122, USA.
FAU - Giordano, Antonio
AU  - Giordano A
AUID- ORCID: 0000-0003-4353-5390
AD  - Sbarro Institute for Cancer Research and Molecular Medicine, Center for 
      Biotechnology, College of Science and Technology, Temple University, 
      Philadelphia, Pennsylvania, PA 19122, USA.
AD  - Department of Medical Biotechnologies, University of Siena, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191215
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Metals, Heavy)
SB  - IM
EIN - J Cell Physiol. 2020 Jul;235(7-8):5860-5861. PMID: 32249427
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - *Early Detection of Cancer
MH  - Female
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - Metals, Heavy/*blood/toxicity
MH  - Middle Aged
MH  - Neoplasms/*blood/chemically induced/pathology
MH  - Persistent Organic Pollutants/*blood/toxicity
MH  - Young Adult
OTO - NOTNLM
OT  - POPs
OT  - cancer
OT  - environmental pollution
OT  - heavy metals
OT  - land of fires
EDAT- 2019/12/16 06:00
MHDA- 2021/03/10 06:00
CRDT- 2019/12/16 06:00
PHST- 2019/09/30 00:00 [received]
PHST- 2019/11/11 00:00 [accepted]
PHST- 2019/12/16 06:00 [pubmed]
PHST- 2021/03/10 06:00 [medline]
PHST- 2019/12/16 06:00 [entrez]
AID - 10.1002/jcp.29399 [doi]
PST - ppublish
SO  - J Cell Physiol. 2020 Jun;235(6):5213-5222. doi: 10.1002/jcp.29399. Epub 2019 Dec 
      15.