PMID- 31839442
OWN - NLM
STAT- MEDLINE
DCOM- 20210720
LR  - 20210720
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Linking)
VI  - 31
IP  - 3
DP  - 2020 Mar
TI  - Endocrinological Toxicity Secondary to Treatment of Gastroenteropancreatic 
      Neuroendocrine Neoplasms (GEP-NENs).
PG  - 239-255
LID - S1043-2760(19)30225-5 [pii]
LID - 10.1016/j.tem.2019.11.003 [doi]
AB  - Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are increasingly 
      recognized, characterized by prolonged survival even with metastatic disease. 
      Their medical treatment is complex involving various specialties, necessitating 
      awareness of treatment-related adverse effects (AEs). As GEP-NENs express 
      somatostatin receptors (SSTRs), long-acting somatostatin analogs (SSAs) that are 
      used for secretory syndrome and tumor control may lead to altered glucose 
      metabolism. Everolimus and sunitinib are molecular targeted agents that affect 
      glucose and lipid metabolism and may induce hypothyroidism or hypocalcemia, 
      respectively. Chemotherapeutic drugs can affect the reproductive system and water 
      homeostasis, whereas immunotherapeutic agents can cause hypophysitis and 
      thyroiditis or other immune-mediated disorders. Treatment with radiopeptides may 
      temporarily lead to radiation-induced hormone disturbances. As drugs targeting 
      GEP-NENs are increasingly introduced, recognition and management of 
      endocrine-related AEs may improve compliance and the quality of life of these 
      patients.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Alexandraki, Krystallenia I
AU  - Alexandraki KI
AD  - National and Kapodistrian University of Athens, Athens, Greece; EKPA-LAIKO ENETS 
      Center of Excellence, Athens, Greece. Electronic address: alexandrakik@gmail.com.
FAU - Daskalakis, Kosmas
AU  - Daskalakis K
AD  - National and Kapodistrian University of Athens, Athens, Greece; Department of 
      Surgery, Faculty of Medicine and Health, Orebro University, Orebro, Sweden; 
      EKPA-LAIKO ENETS Center of Excellence, Athens, Greece.
FAU - Tsoli, Marina
AU  - Tsoli M
AD  - National and Kapodistrian University of Athens, Athens, Greece; EKPA-LAIKO ENETS 
      Center of Excellence, Athens, Greece.
FAU - Grossman, Ashley B
AU  - Grossman AB
AD  - University of Oxford, Oxford, UK; Green Templeton College, Oxford, UK; Royal Free 
      London, London, UK; Barts and the London School of Medicine, London, UK.
FAU - Kaltsas, Gregory A
AU  - Kaltsas GA
AD  - National and Kapodistrian University of Athens, Athens, Greece; EKPA-LAIKO ENETS 
      Center of Excellence, Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191212
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
RN  - 0 (Antineoplastic Agents, Immunological)
RN  - Gastro-enteropancreatic neuroendocrine tumor
SB  - IM
MH  - Antineoplastic Agents, Immunological/adverse effects
MH  - Antineoplastic Combined Chemotherapy Protocols/*adverse effects/therapeutic use
MH  - Carcinoma, Neuroendocrine/drug therapy
MH  - Drinking/drug effects
MH  - Endocrine System Diseases/*chemically induced/epidemiology/prevention & 
      control/therapy
MH  - Gastrointestinal Neoplasms/drug therapy
MH  - Genitalia/drug effects/physiology
MH  - Humans
MH  - Immune System Diseases/chemically induced/epidemiology/therapy
MH  - Intestinal Neoplasms/*drug therapy
MH  - Neuroendocrine Tumors/*drug therapy
MH  - Pancreatic Neoplasms/*drug therapy
MH  - Stomach Neoplasms/*drug therapy
MH  - Water-Electrolyte Imbalance/chemically induced/epidemiology/prevention & control
EDAT- 2019/12/17 06:00
MHDA- 2021/07/21 06:00
CRDT- 2019/12/17 06:00
PHST- 2019/09/14 00:00 [received]
PHST- 2019/10/16 00:00 [revised]
PHST- 2019/11/12 00:00 [accepted]
PHST- 2019/12/17 06:00 [pubmed]
PHST- 2021/07/21 06:00 [medline]
PHST- 2019/12/17 06:00 [entrez]
AID - S1043-2760(19)30225-5 [pii]
AID - 10.1016/j.tem.2019.11.003 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2020 Mar;31(3):239-255. doi: 10.1016/j.tem.2019.11.003. 
      Epub 2019 Dec 12.