PMID- 31839635
OWN - NLM
STAT- MEDLINE
DCOM- 20191219
LR  - 20200108
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 60
IP  - 11
DP  - 2019
TI  - [Successful treatment with recombinant thrombomodulin in transplant-associated 
      thrombotic microangiopathy following HLA-haploidentical transplantation].
PG  - 1560-1566
LID - 10.11406/rinketsu.60.1560 [doi]
AB  - In March 2009, a 17-year-old woman was first diagnosed with acute myelogenous 
      leukemia and myelodysplasia-related changes. She underwent chemotherapy and 
      allogeneic hematopoietic stem cell transplantation, which resulted in complete 
      remission. However, she experienced relapse, and remission was achieved each time 
      with repeated transplantation. In September 2014, a human leukocyte antigen 
      (HLA)-haploidentical transplantation, which was the fifth allogeneic 
      transplantation, was performed to treat the third relapse. Platelet transfusion 
      refractoriness, hemolytic anemia with schistocytes, and renal dysfunction were 
      observed from approximately the day of engraftment; therefore, 
      transplantation-associated thrombotic microangiopathy (TA-TMA) was diagnosed. 
      Recombinant human soluble thrombomodulin (rTM) was administered, and fresh-frozen 
      plasma (FFP) was infused; this resulted in gradual improvement of TA-TMA. 
      Treatment with rTM and FFP was discontinued on the 70th day after 
      transplantation. Because the HLA-haploidentical transplantation was the fifth 
      allogeneic transplantation, the risk of aggravation of TA-TMA was very high. 
      Combined treatment with rTM and FFP, however, resulted in improvement of TA-TMA. 
      Further investigation of similar cases is necessary for clarifying the usefulness 
      of rTM for TA-TMA.
FAU - Otsuka, Yasuyuki
AU  - Otsuka Y
AD  - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto 
      University.
FAU - Kondo, Tadakazu
AU  - Kondo T
AD  - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto 
      University.
FAU - Nomura, Ryosuke
AU  - Nomura R
AD  - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto 
      University.
FAU - Yamashita, Kouhei
AU  - Yamashita K
AD  - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto 
      University.
FAU - Takaori-Kondo, Akifumi
AU  - Takaori-Kondo A
AD  - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto 
      University.
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - 0 (HLA Antigens)
RN  - 0 (Thrombomodulin)
SB  - IM
MH  - Adolescent
MH  - Female
MH  - HLA Antigens
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Humans
MH  - Thrombomodulin/*therapeutic use
MH  - *Thrombotic Microangiopathies/drug therapy/etiology
MH  - Transplantation, Haploidentical/*adverse effects
OTO - NOTNLM
OT  - HLA-haploidentical transplantation
OT  - Recombinant human soluble thrombomodulin
OT  - Transplantation-associated thrombotic microangiopathy
EDAT- 2019/12/17 06:00
MHDA- 2019/12/20 06:00
CRDT- 2019/12/17 06:00
PHST- 2019/12/17 06:00 [entrez]
PHST- 2019/12/17 06:00 [pubmed]
PHST- 2019/12/20 06:00 [medline]
AID - 10.11406/rinketsu.60.1560 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2019;60(11):1560-1566. doi: 10.11406/rinketsu.60.1560.