PMID- 31840005
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 2152-6575 (Print)
IS  - 2152-6567 (Electronic)
IS  - 2152-6567 (Linking)
VI  - 10
DP  - 2019 Jan-Dec
TI  - No Bull: A Case of Alpha-Gal Syndrome Associated With Buffalo Meat Sensitivity.
PG  - 2152656719893366
LID - 10.1177/2152656719893366 [doi]
LID - 2152656719893366
AB  - INTRODUCTION: Alpha (⍺)-gal syndrome (AGS) is an immunoglobulin E (IgE) antibody 
      response against the glycoprotein carbohydrate 
      galactose-⍺-1,3-galactose-beta-1-(3)4-N-acetylglucosamine-R 
      (Gal⍺-1,3Galbeta1-(3)4GlcNAc-R or ⍺-gal) that is present in Ixodida (tick) saliva 
      and noncatarrhine mammals as well as cetuximab, antivenom, and the zoster 
      vaccine. The most frequently observed anaphylactic reactions in AGS are observed 
      after beef, pork, lamb, and deer meat consumption. We present the first case of 
      anaphylaxis to buffalo meat. CASE REPORT: A 55-year-old man presented with a 
      history of recurrent urticaria that only developed approximately 7 hours after 
      buffalo consumption. The patient denied history of Ixodidae bites but admitted to 
      frequent hiking outdoors. Anti-⍺-1,3-gal IgE was positive (30.80 kU/L). The 
      patient was advised to strictly avoid red meat. DISCUSSION: The prevalence of AGS 
      has been increased in all continents in the past decade, and several Ixodidae 
      species have been associated with this hypersensitivity. The list of IgE-mediated 
      reactions to various types of meat has expanded to kangaroo, whale, seal, and 
      crocodile, although these have not been associated with AGS. van Nunen only 
      cautioned against consumption of exotic meats, such as buffalo, but no published 
      case report describes AGS associated with anaphylaxis to this type of meat. 
      CONCLUSION: AGS is a mammalian meat allergy that has been increasingly prevalent 
      worldwide, especially in Ixodidae endemic regions of Australia and the United 
      States. Multiple AGS case reports published in the past decade demonstrate 
      rapidly increasing understanding of underlying mechanisms provoking ongoing 
      sensitization to help devise management strategies and dietary information. We 
      offer the first case report of delayed anaphylaxis to buffalo meat.
CI  - (c) The Author(s) 2019.
FAU - Rowane, Marija
AU  - Rowane M
AUID- ORCID: 0000-0002-6500-8279
AD  - Heritage College of Osteopathic Medicine, Ohio University, Cleveland, Ohio.
AD  - Allergy Immunology Associates, Inc., Mayfield Heights, Ohio.
FAU - Valencia, Reimus
AU  - Valencia R
AD  - Department of Pulmonary and Critical Care, University Hospitals Cleveland Medical 
      Center, Cleveland, Ohio.
FAU - Stewart-Bates, Benjamin
AU  - Stewart-Bates B
AD  - Heritage College of Osteopathic Medicine, Ohio University, Cleveland, Ohio.
FAU - Casselman, Jason
AU  - Casselman J
AD  - Department of Internal Medicine-Allergy & Immunology, Reid Health, Richmond, 
      Indiana.
FAU - Hostoffer, Robert Jr
AU  - Hostoffer R Jr
AD  - Allergy Immunology Associates, Inc., Mayfield Heights, Ohio.
AD  - Department of Pulmonary and Critical Care, University Hospitals Cleveland Medical 
      Center, Cleveland, Ohio.
LA  - eng
PT  - Case Reports
DEP - 20191208
PL  - United States
TA  - Allergy Rhinol (Providence)
JT  - Allergy & rhinology (Providence, R.I.)
JID - 101570968
PMC - PMC6902388
OTO - NOTNLM
OT  - alpha-gal syndrome
OT  - anaphylaxis
OT  - buffalo meat
EDAT- 2019/12/17 06:00
MHDA- 2019/12/17 06:01
PMCR- 2019/12/08
CRDT- 2019/12/17 06:00
PHST- 2019/12/17 06:00 [entrez]
PHST- 2019/12/17 06:00 [pubmed]
PHST- 2019/12/17 06:01 [medline]
PHST- 2019/12/08 00:00 [pmc-release]
AID - 10.1177_2152656719893366 [pii]
AID - 10.1177/2152656719893366 [doi]
PST - epublish
SO  - Allergy Rhinol (Providence). 2019 Dec 8;10:2152656719893366. doi: 
      10.1177/2152656719893366. eCollection 2019 Jan-Dec.